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QUT researchers have developed a new approach for designing molecular ON-OFF switches based on proteins which can be used in a multitude of biotechnological, biomedical and bioengineering applications.

The research team demonstrated that this novel approach allows them to design and build faster and more accurate diagnostic tests for detecting diseases, monitoring water quality and detecting environmental pollutants.

Professor Kirill Alexandrov, of the QUT School of Biology and Environmental Science, lead scientist on the CSIRO-QUT Synthetic Biology Alliance and a researcher with the ARC Centre of Excellence in Synthetic Biology, said that the new technique published in the prestigious scientific journal Nature Nanotechnology demonstrated that protein switches could be engineered in a predictable way.

One of the key challenges in TDA is to distinguish between “signal”—meaningful structures underlying the data, and “noise”—features that arise from the local randomness and inaccuracies within the data15,16,17. The most prominent solution developed in TDA to address this issue is persistent homology. Briefly, it identifies structures such as holes and cavities (“air pockets”) formed by the data, and records the scales at which they are created and terminated (birth and death, respectively). The common practice in TDA has been to use this birth-death information to assess the statistical significance of topological features18,19,20,21. However, research so far has yet to provide an approach which is generic, robust, and theoretically justified. A parallel line of research has been the theoretical probabilistic analysis of persistent homology generated by random data, as means to establish a null-distribution. While this direction has been fruitful22,23,24,25, its use in practice has been limited. The main gap between theory and practice is that these studies indicate that the distribution of noise in persistent homology: (a) does not have a simple closed-form description, and (b) strongly depends on the model generating the point-cloud.

Our main goal in this paper is to refute the last premise, and to make the case that the distribution of noise in persistent homology of random point-clouds is in fact universal. Specifically, we claim that the limiting distribution of persistence values (measured using the death/birth ratio) is independent of the model generating the point-cloud. This result is loosely analogous to the central limit theorem, where sums of many different types of random variables always converge to the normal distribution. The emergence of such universal ity for persistence diagrams is highly surprising.

We support our universal ity statements by an extensive body of experiments, including point-clouds generated by different geometries, topologies, and probability distributions. These include simulated data as well as data from real-world applications (image processing, signal processing, and natural language processing). Our main goal here is to introduce the unexpected behavior of statistical universal ity in persistence diagrams, in order to initiate a shift of paradigm in stochastic topology that will lead to the development of a new theory. Developing this new theory, and proving the conjectures made here, is anticipated to be an exciting yet a challenging long journey, and is outside the scope of this paper. Based on our universal ity conjectures, we develop a powerful hypothesis testing framework for persistence diagrams, allowing us to compute numerical significance measures for individual features using very few assumptions on the underlying model.

Starlink, Elon Musk’s satellite internet service, is set to launch an internet connection service in Bangladesh to connect geographically isolated (hard to reach) or disaster-affected populations with uninterrupted high-speed Internet.

Starlink provided two devices for a three-month test run, State Minister for Information and Communication Technology Zunaid Ahmed Palak told Dhaka Tribune after the meeting.

One of the devices will be installed on a bus while another device will be installed on a remote island in Bangladesh to test the compatibility of this internet service.

AI startup Stability AI continues to refine its generative AI models in the face of increasing competition — and ethical challenges.

Today, Stability AI announced the launch of Stable Diffusion XL 1.0, a text-to-image model that the company describes as its “most advanced” release to date. Available in open source on GitHub in addition to Stability’s API and consumer apps, ClipDrop and DreamStudio, Stable Diffusion XL 1.0 delivers “more vibrant” and “accurate” colors and better contrast, shadows and lighting compared to its predecessor, Stability claims.

In an interview with TechCrunch, Joe Penna, Stability AI’s head of applied machine learning, noted that Stable Diffusion XL 1.0, which contains 3.5 billion parameters, can yield full 1-megapixel resolution images “in seconds” in multiple aspect ratios. “Parameters” are the parts of a model learned from training data and essentially define the skill of the model on a problem, in this case generating images.

Suumit Shah, a 31-year-old CEO of an e-commerce platform called Dukaan based in India, is getting torn to shreds online for firing 90 percent of the company’s customer support staff after arguing that an AI chatbot had outperformed them.

It was an unusually callous announcement that clearly didn’t sit well with plenty of netizens, as Insider reports.

“We had to layoff [sic] 90 percent of our support team because of this AI chatbot,” he tweeted. “Tough? Yes. Necessary? Absolutely.”