Chinese researchers have announced in a video that they’ve verified LK-99’s ability to conduct current with zero resistance, but questions still linger.
Migraines are characterized by moderate to severe headache attacks and are commonly considered polygenic disorders. Typically, migraines are treated with triptans like serotonin receptor agonists; however, the mechanisms of triptans are debated upon, with these agents only effective in only about 60% of the population.
A new Scientific Reports study discusses the mechanisms of triptans for the treatment of spontaneous migraine attacks by using transcriptomics and metabolomics.
Glossy white-concrete panels clad this holiday home with a pentagonal plan in Italy, which has been designed by Milan studio JM Architecture.
The dwelling is named Pinwheel after its distinctive shape, which was JM Architecture’s solution for the client’s “only request” – that it offers views of both the nearby Lake Maggiore and surrounding alpine valleys.
“While exploring several design options for a compact house to fit on this small plot, we realised that the building constraints and the client’s requirements resulted in the simple geometry of a pentagon shape,” said JM Architecture founder Jacopo Mascheroni.
A pioneering dental medicine project in Japan is making strides toward clinical trials, with the aim of becoming the world’s first tooth-regrowing treatment, according to the country’s national news site Mainichi.
The upcoming trial will be focused on patients affected by anodontia, a genetic condition characterized by the absence of teeth, or partial anodontia, where people are missing some teeth, as described by the National Organization for Rare Disorders (NORD).
Clinical trials are scheduled to begin next July in Japan. If successful, regulatory approval for the tooth-regrowing medicine is anticipated by 2030, potentially heralding groundbreaking advancements in dentistry.
Antiviral therapies are notoriously difficult to develop, as viruses can quickly mutate to become resistant to drugs, or hide within cells. Researchers at NYU have now developed a new approach to antiviral treatment that ignores the fast-mutating proteins on the surface of viruses and instead targets lipids in the membranes of enveloped viruses, which disrupts their protective layers. In a newly published study the researchers showed how these novel peptoid molecules, inspired by the immune system, could inactivate several viruses, including Zika and chikungunya. The team suggests their approach may not only lead to drugs that can be used against many viruses, but could also help overcome antiviral resistance.
“We found an Achilles heel of many viruses: their bubble-like membranes,” said Kent Kirshenbaum, PhD, professor of chemistry at NYU. “Exploiting this vulnerability and disrupting the membrane is a promising mechanism of action for developing new antivirals.” Kirshenbaum is senior author of the team’s published paper in ACS Infectious Diseases, which is titled “Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity.”
In their paper the authors concluded, “We provide the first evidence for the engagement of distinct viral envelope lipid constituents, establishing an avenue for specificity that may enable the development of a new family of therapeutics capable of averting the rapid development of resistance.”
Year 2001 😗😁
Stable levitation of one magnet by another with no energy input is usually prohibited by Earnshaw’s theorem. However, the introduction of diamagnetic material at special locations can stabilize such levitation. A magnet can even be stably suspended between (diamagnetic) fingertips. A very simple, surprisingly stable room temperature magnet levitation device is described that works without superconductors and requires absolutely no energy input. Our theory derives the magnetic field conditions necessary for stable levitation in these cases and predicts experimental measurements of the forces remarkably well. New levitation configurations are described which can be stabilized with hollow cylinders of diamagnetic material. Measurements are presented of the diamagnetic properties of several samples of bismuth and graphite.
😀 😍 🤩
Imaginima / iStock.
The system, called the IVO Quantum Drive, will launch atop a SpaceX Falcon 9 rocket as part of the rideshare mission Transporter 8.
Newly released data taken using the Belle II experiment at KEK in Japan and the LHCb experiment at CERN in Switzerland show no sign of a possible anomaly that researchers think could provide a route to overturning the standard model of particle physics [1– 3].
According to the standard model, electrons, muons, and tau leptons should all behave identically when subjected to any of the fundamental forces of nature. Over a decade ago, researchers began questioning the validity of this assumption—known as lepton universality—when they observed high-energy particle decays that deviated from standard-model predictions. Specifically, the observations concerned the decay of B mesons into various leptons, with the experiments hinting that a few more tau leptons were being produced than expected. Excitement built among particle physicists, who hoped they were on the cusp of finding the long-sought standard-model violation that would uncover new physical phenomena. Hopes rose further as other experiments found hints of lepton-universality violations in the decay of B mesons into electrons and muons, but the signals remained too small to rule out experimental artifacts.
Then at the end of last year, hopes began to fade when the LHCb Collaboration released data for B-meson decays involving electrons and muons that exactly matched standard-model predictions [2, 3]. Now data from the Belle II Collaboration for a different B-meson decay involving electrons and muons dim those hopes further [1]. The study provides the most precise lepton-universality test yet in such decays. But researchers haven’t yet given up on leptons unlocking a door to new physics, says Belle II Collaboration member Henrik Junkerkalefeld of the University of Bonn, Germany. He notes that, although the results provide new constraints on the options for undiscovered physics, they don’t completely rule them all out.
In 2021, retired actor Bruce Willis gave video production firm DeepCake permission to use deepfake tech to insert his likeness into a series of advertisements — and the AI they trained for the project could allow him to keep entertaining fans well into the future.
Authorized deepfake: In March 2022, Willis’ family announced that he would be stepping away from acting due to a recent diagnosis of aphasia, a language disorder that was impairing his cognitive abilities.
One of the action star’s last projects was a series of ads for Russian telecom company MegaFon, but it turned out he didn’t really act in the commercials — the ads were deepfakes that used AI to insert Willis digitally into the videos.
Canadian architecture studio Atelier l’Abri has built a series of A-Frame buildings for the Farouche Tremblant agrotourism site in Québec’s Mon-Tremblant National Park, which were designed to “recede in the landscape”.
Intending to celebrate and showcase the surrounding untamed woodlands, Atelier l’Abri created a cafe, farm and four rental micro–cabins that act as a basecamp for visitors wanting to explore the nearby Devil’s River and its valley.
Sitting among the wild terrain, the four small rental cabins have steep-pitched roofs clad in cedar shingles that extend to the ground to form sloping walls.