Toggle light / dark theme

Which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs); but growing evidence indicate that transcriptional programs beyond HIFs control tumor angiogenesis. Here we show that the redox-sensitive transcription factor BTB and CNC homology 1 (BACH1) controls the transcription of a broad range of angiogenesis genes. BACH1 is stabilized by lowering reactive oxygen species levels; consequently, angiogenesis gene expression in lung cancer cells, tumor organoids, and xenograft tumors increased substantially following vitamin C and E and N-acetylcysteine administration in a BACH1-dependent fashion under normoxia. Moreover, angiogenesis gene expression increased in endogenous BACH1–overexpressing cells and decreased in BACH1-knockouts in the absence of antioxidants.

What do you think? China is doing it. The West is going to have to keep up. Have you seen the Netflix series Altered Carbon? It’s like that.


A U.S. Army video shows its concept of the soldier of the future. At first glance, it looks like it will only be a better-equipped soldier.

But the video mentions “neural enhancement.” That can mean a brain implant that connects a human to computers. The defense agency DARPA has been working on an advanced implant that would essentially put the human brain “online.” There could also be eye and ear implants and other circuitry under the skin to make the optimal fighting machine.

Citizen Lab says two zero-days fixed by Apple today in emergency security updates were actively abused as part of a zero-click exploit chain (dubbed BLASTPASS) to deploy NSO Group’s Pegasus commercial spyware onto fully patched iPhones.

The two bugs, tracked as CVE-2023–41064 and CVE-2023–41061, allowed the attackers to infect a fully-patched iPhone running iOS 16.6 and belonging to a Washington DC-based civil society organization via PassKit attachments containing malicious images.

“We refer to the exploit chain as BLASTPASS. The exploit chain was capable of compromising iPhones running the latest version of iOS (16.6) without any interaction from the victim,” Citizen Lab said.

ROCHESTER, Minn. — In a randomized trial, published in The Lancet Oncology, Mayo Clinic Comprehensive Cancer Center researchers uncover evidence supporting a shorter treatment time for breast cancer patients. The study compared two separate dosing schedules of pencil-beam scanning proton therapy, the most advanced type of proton therapy known for its precision in targeting cancer cells while preserving healthy tissue to reduce the risk of side effects.

Survival rates for breast cancer continue to improve due to advances in diagnosis and treatment, leading to increasing emphasis on reducing the long-term toxicity of cancer treatment, including radiotherapy.

Prior to this study, all patients treated with proton postmastectomy radiotherapy (PMRT) had received a conventional 25-to 30-day course delivered five days per week over five to six weeks. The researchers hoped to demonstrate that condensing the course of proton beam therapy, a form of particle therapy that could spare the heart and lungs from radiation damage, may result in a similar side effect profile.