Lifeboat Foundation: Safeguarding Humanity
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Sean Carroll is a theoretical physicist who serves as a Homewood Professor of Natural Philosophy at Johns Hopkins University. Carroll strives to convey complicated physics concepts in accessible terms on his Mindscape podcast and in his popular books, including last year’s The Biggest Ideas in the Universe: Space, Time, and Motion. He joins Preet to talk about the relationship between science and philosophy, how to comprehend quantum mechanics, and whether there are billions of similar universes operating alongside our own.

Plus, Special Counsel David Weiss’s testimony in front of the House Judiciary Committee about the Hunter Biden prosecution and Trump’s reported plan to use the Department of Justice for revenge if he retakes the presidency.

Don’t miss the Insider bonus, where Preet and Carroll talk more about depictions of time travel in Hollywood films. To listen, become a member of CAFE Insider for $1 for the first month. Head to cafe.com/insider.

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Bryan Johnson is the world’s most famous biohacker – and perhaps the “most measured man in human history”. He’s on a mission to maximally reverse the quantified biological age of each of his 70 organs, extending his lifespan and healthspan, and then roll out his protocol on a platform to ensure others can benefit from his experience, research and experimentation.

Johnson’s ethos can be summed up pretty neatly as don’t die, and to that end, he has written a book, or novel, to be more accurate, entitled Don’t Die, the uncorrected advanced reading version of which is downloadable as a free ebook from his website. Johnson’s nom de plume for this venture is Zero, described in the book as the “first individual H. sapiens to surpass five hundred years of age,” who dies in 2,478 (in an accident, rather than from old age), just weeks away from “becoming Homo Deus.” Johnson credits Zero with the invention of Zeroism and the resurrection technology undie, as well as the fathering of “millions of biological and digital offspring who now live in the far reaches of the solar system and beyond”

Longevity. Technology: Because Don’t Die is a novel, Johnson can explore his philosophy in a different way, inviting us to observe the narrator, Scribe, on his last day on Earth, as he muses on humanity’s future evolution, the nature of death and free will and the impact of age reversal and programmable biology. Scribe is joined by a Pilgrim’s Progress-like cast of characters, including Cognitive Bias, Dark Humor and Game Play and Self Critical.

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Fellow Macquarie University researchers Dr Ram Maharjan and Associate Professor Amy Cain are part of a contingent of scientists coming at the issue from another direction: studying a single protein that, when damaged, causes A. baumannii to lose its superpowers, compromising a drug pumping system that pushes antibiotics and other threats out of the cell.

While further studies are needed to understand how biocides work and how they interact with antibiotics, Dr Li stressed we should not discontinue their use in healthcare facilities and in the community.

“The findings in our study suggest that residual biocides could compromise antibiotic potency, at least in the lab,” Dr Li said.

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The Rejuvenation Startup Summit (Berlin, May 10–11, 2024) hosted by the Forever Healthy Foundation, is a vibrant networking event that aims to accelerate the development of the rejuvenation biotech industry.

Rejuvenation/longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself. Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification, tissue stiffening, loss of stem cell function, genetic alterations, and impaired energy production.

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A first-of-its-kind flexible sensor turns a pair of earbuds into a device capable of recording brain activity and analyzing sweat, making them useful for diagnosing diseases and health monitoring.

The background: Health monitoring wearables can measure our blood pressure, track our heart rates, and even detect infections before we start to feel sick, helping us take better care of ourselves and potentially even giving us a way to prevent the spread of diseases.

The devices are useless if no one wants to wear them, though, so finding designs that are comfortable and easy to integrate into daily life is key. Because earbuds are already popular, researchers have used them as the basis for health monitoring devices that record brain activity to predict strokes, epileptic seizures, or Parkinson’s disease.

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Stanford researchers have finally figured out how a therapy that blocks a single protein can reverse age-related muscle loss in mice — and the discovery suggests seniors might not be the only ones who could benefit from it.

Age-related muscle loss: People tend to start losing muscle mass and strength in their 30s, and from 50 on, you could be losing up to 10% of your muscle mass every decade.

While it is possible to regain lost muscle through exercise, health issues can make hitting the weights a challenge. If left unaddressed, though, age-related muscle loss can lead to decreased mobility and weakness, which increases the risk of falls or other injuries.

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OpenAI has confirmed that a distributed denial-of-service (DDoS) attack is behind “periodic outages” affecting ChatGPT and its developer tools.

ChatGPT, OpenAI’s AI-powered chatbot, has been experiencing sporadic outages for the past 24 hours. Users who attempted to access the service have been greeted with a message stating that “ChatGPT is at capacity right now,” and others, including TechCrunch, have been unable to log into the service.

OpenAI CEO Sam Altman initially blamed the issue on interest in the platform’s new features, unveiled at the company’s first developer conference on Monday, “far outpacing our expectations.” OpenAI said the issue was fixed at approximately 1 p.m. PST on November 8.

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Chptr, an app for sharing and holding onto memories of lost loved ones, has raised $1.5 million in seed funding. The app is designed to give people a way to encapsulate the life of their loved ones by inviting others to share and store stories, images, audio messages, videos and more all in one place.

The startup was founded in 2020 by Rehan Choudhry, who came up with the idea for the app when he was helping his wife, a news anchor at CBS New York, put together video tributes for the first victims of COVID-19 in New York City. Choudhry told TechCrunch in an interview that the pair was reaching out to the families, friends, neighbors and colleagues of the victims to paint a picture of what their life was like.

“The thing I realized after talking to a lot of families was that these videos served as almost a reunion point for people that they will continue to grieve around,” Choudhry said. “We noticed that the grieving process that would normally take 90 days was extended to months because they had something to rally around. So then the question for me was why doesn’t everyone on the planet have access to this because we all have smartphones and social media. So I went down the rabbit hole of discovery and it brought me to Chptr.”

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