Lifeboat Foundation

Researchers have found that people with obstructive sleep apnea have an increased cardiovascular risk due to reduced blood oxygen levels, largely explained by interrupted breathing. Obstructive sleep apnea has long been associated with increased risk of cardiovascular issues, including heart attack, stroke, and death, but the findings from this study, published in the American Journal of Respiratory and Critical Care Medicine, show the mechanism mostly responsible for the link.

“These findings will help better characterize high-risk versions of obstructive sleep apnea,” said Ali Azarbarzin, Ph.D., a study author and director of the Sleep Apnea Health Outcomes Research Group at Brigham and Women’s Hospital and Harvard Medical School, Boston. “We think that including a higher-risk version of obstructive sleep apnea in a randomized clinical trial would hopefully show that treating sleep apnea could help prevent future cardiovascular outcomes.”

Researchers reviewed data from more than 4,500 middle-aged and older adults who participated in the Osteoporotic Fractures in Men Study (MrOS) and the Multi-Ethnic Study of Atherosclerosis (MESA), and sought to identify features of obstructive sleep apnea that could explain why some people were more likely than others to develop cardiovascular disease or related death.

Antimicrobial peptides (AMPs)—small peptides that protect against microbial infection—are crucial immune effectors in both plants and animals. They not only fight against potential infections, they also influence the composition of the host’s microbiome. Little is known about the driving forces behind AMPs’ rapid evolution. Now, a study uncovers the selective pressures driving the evolution of AMPs and how they control bacteria in the host’s microbiome.

The work is published in Science in the paper, “Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila.”

The researchers focused on Diptericin (Dpt), a small antimicrobial peptide that mainly defends Drosophila against Gram-negative bacteria. The team examined how Diptericins function in Drosophila and evolve in response to their microbial environment.

I used to wear Vans when I was a kid. I hope I can buy these. I forgot about them. They are from the Space Voyager collection. There is a link below. Imagine if Lifeboat had a shoe. What merchandise does Lifeboat have? T-Shirts are easy to make, can not just make money, but also are a walking advertisement that can even have the web address on it.

https://www.vans.eu/space-voyager.html

A Sk8-Hi MTE & Old Skool are on the way.

Continue reading “NASA x Vans Collection Finally Receives Release Date” »

An international team led by investigators at McLean Hospital has analyzed the genes expressed in approximately 575,000 individual cells from the brains of people with and without post-traumatic stress and major depressive disorders (PTSD and MDD), revealing new insights into the mechanisms behind the brain’s stress response in these conditions.

The findings, which are published in The American Journal of Psychiatry, could lead to novel markers of PTSD and MDD and well as new therapeutic targets.

Because studies have implicated the dorsolateral prefrontal cortex (DLPFC) region of the brain in PTSD and MDD, the scientists compared the genes expressed in cells in DLPFC samples collected postmortem from 11 individuals with PTSD, 10 with MDD, and 11 without either of these conditions with a replication dataset half the size. The researchers detected which genes were expressed by which cells—including eight different types of cells—through a technique called single-cell RNA sequencing.

This post is also available in: עברית (Hebrew)

What is the invisible cost of AI technology? Experts express their worries about privacy breaches.

AI-powered technology is constantly growing, and with it grows the amount of personal information collected and processed. But how do AI-powered apps impact user privacy?

But career experts say work-life balance shouldn’t come at the cost of the workday and that this Gen Zer’s attitude doesn’t reflect the entire generation.

How careful observation, strict reasoning and clever hypotheses guided the great human endeavor of science.

Scientists at the University of Colorado Anschutz Medical Campus have discovered what they believe to be the central mechanism behind cognitive decline associated with normal aging.

“The mechanism involves the mis-regulation of a brain protein known as CaMKII which is crucial for memory and learning,” said the study’s co-senior author Ulli Bayer, PhD, professor of pharmacology at the University of Colorado School of Medicine. “This study directly suggests specific pharmacological treatment strategies.”

The study was published today in the journal ‘Science Signaling.’

Luismmolina/iStock.

However, researchers from Denmark’s Herlev Hospital and UK-based Cardiff University, and the University of Warwick recently published a study that reveals a new superior T-cell which is better at detecting cancer growth and can attack multiple cancer targets.