Lifeboat Foundation

To show the capability of the OrganoidChip in enabling higher-resolution imaging, we used confocal microscopy for several organoids immobilized on the chip. Representative images show improved optical segmentation and the ability to resolve single cells within an organoid (Fig. 4 d). The co-localized EthD-1-and Hoechst-stained nuclei are resolvable and can potentially be used to increase the accuracy of viability measurements. Future implementation of 3D-segmentation using AI-assisted algorithms in the analysis pipeline can provide more accurate estimations of cellular viability in larger screens.

Next, we measured the effect of DOX treatment on the beating kinetics of cardiac organoids. To do this, we relied on calcium fluorescence imaging, as it has been shown to be a good approximation of the cardiomyocytes’ action potentials³². Calcium imaging proved beneficial for beating and contraction parameters since smaller beating portions cannot necessarily be detected from brightfield images, particularly when organoids have been compromised as a result of drug treatment.

When assessing drug effects, we observed some degree of variability in the spontaneous contractile behaviour and beating kinetics between cardiac organoids. Such variability often skews any averaged parameter value across organoids and does not reflect the effect of the treatment conditions on organoid health. To address this challenge, we tracked each individual organoid’s beating off-and on-chip. The drug-induced functionality results are therefore reported as averages of fractional changes of each individual organoid’s beating kinetics parameters, measured at 48 h post-treatment, on both the chamber slide and on the chip, relative to its pre-treatment value (Eq. 3).

An international team of researchers, including members from the Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU), has succeeded in a proof-of-principle experiment to verify strong-field quantum electrodynamics within exotic atoms, according to a recent study published in Physical Review Letters.

Physical Review Letters (PRL) is a peer-reviewed scientific journal published by the American Physical Society. It is one of the most prestigious and influential journals in physics, with a high impact factor and a reputation for publishing groundbreaking research in all areas of physics, from particle physics to condensed matter physics and beyond. PRL is known for its rigorous standards and short article format, with a maximum length of four pages, making it an important venue for rapid communication of new findings and ideas in the physics community.

A trio of astrophysicists, two from Colgate University and the third from the University of Texas, has found evidence of dark stars courtesy of data from the James Webb Space Telescope. In their study, reported in Proceedings of the National Academy of Sciences, Cosmin Ilie, Jillian Paulin and Katherine Freese, analyzed three galaxies spotted by the JWST and how they might relate to dark stars.

Back in 2007, Freese, along with Douglas Spolyar and Paolo Gondolo, proposed the idea of a dark star —rather than nuclear fusion, these theorized dark stars are powered by dark matter. Since that time, researchers have continued to study the idea of such a star, built models to show what they might look like and derived a list of characteristics that such a star might have. In the current study, Ilie, Paulin and Freese have found three candidates in Webb data that fit the bill.

Dark stars, the team suggests, likely could have been born during the early days of the universe—like other stars, they would have been made mostly of helium and hydrogen. But they would also contain dark matter—enough to provide a heat source. Such stars would not then be lit by nuclear fusion. If such stars did exist, they would be much larger than other types of stars that have been observed—so large that they might look like galaxies from Earth-based telescopes.

New military and commercial craft aim to go far higher than jumbo jets and stay there for months, offering a more flexible alternative to satellites.

While Tesla famously won’t support CarPlay, code found in its iOS app update points to at least testing of AirPlay in its cars.

It’s never been possible to use Apple’s CarPlay in Teslas — not without a hack, and a convoluted one at that — but CEO Elon Musk has previously hinted at AirPlay support.

Now according to the unofficial “Tesla App Updates (iOS)” account on Twitter, the latest version of Tesla’s iPhone app includes a mention of AirPlay in its code.

These monochromatic projects stray from typical partitions, using curved surfaces and smooth finishes to create intrigue, interaction and individuality in the cultural sector.

There are various ways to create space and bring the brain into a state that is conducive to strategic thinking:

• Sustain a regular meditation practice.

• Use breathwork to calm down.

Continue reading “The Neuroscience Of Strategic Thinking And Executive Coaching” »

An interdisciplinary team at the Advanced Quantum Testbed (AQT) at Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California, Berkeley’s Quantum Nanoelectronics Laboratory (QNL) achieved a technical breakthrough using qutrits—three-level systems—on a superconducting quantum processor.

The team successfully entangled two transmon qutrits with gate fidelities significantly higher than in previously reported works, thus getting closer to enabling ternary logic that can encode more information than their binary counterparts—qubits.

Published in Nature Communications in December 2022 and featured as an editor’s highlight, this experimental success pushes forward AQT’s qutrit research and development, including previous experimental successes published in 2021 in Physical Review X and Physical Review Letters. Ternary quantum information processors offer significant potential advantages in quantum simulation and error correction, as well as the ability to improve certain quantum algorithms and applications.

CRISPR genome editing technologies are shaping the future of drug development. We spoke to industry experts to learn more about its potential.