Interlock ransomware is actively exploiting CVE-2026–20131 (CVSS 10.0) in Cisco FMC, enabling unauthenticated remote code execution as root.
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Aura confirms data breach exposing 900,000 marketing contacts
Identity protection company Aura has confirmed that an unauthorized party gained access to nearly 900,000 customer records containing names and email addresses.
The company states that the incident was caused by a voice phishing attack targeting an employee, which exposed the sensitive data of 20,000 current and 15,000 former customers.
In a communication this week, Aura states that the data originated from a marketing tool used by a company acquired by Aura in 2021, which exposed limited information.
New “Darksword” iOS exploit used in infostealer attack on iPhones
A new exploit kit for iOS devices and delivery framework dubbed “DarkSword” has been used to steal a wide range of personal information, including data from cryptocurrency wallet apps.
DarkSword targets iPhones running iOS 18.4 through 18.7 and is linked to multiple actors, including UNC6353, suspected to be Russian, who used the Coruna exploit chain disclosed earlier this month.
Researchers at mobile security company Lookout discovered DarkSword while investigating the infrastructure used for the Coruna attacks. Google’s Threat Intelligence Group and iVerify also collaborated for a more comprehensive analysis of this previously unknown threat and the adversaries leveraging it.
Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke
New study from Weijie Chen, Xin Wang, Tingting Huang, Weifeng Yu.
Florent Ginhoux, Peiying Li (Shanghai Jiao Tong University) and colleagues identifies hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived macrophages in the ischemic brain after stroke through mediating phosphatidylcholine synthesis.
This study identifies hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived macrophages i.
USP10 Deubiquitinates MTX2 to Suppress cGAS-STING Signaling in MI
Zhao & colleagues found how a protective protein, USP10, helps limit excessive inflammation after a heart attack, which may open new avenues for treating cardiac injury. Learn more at.
BACKGROUND: Myocardial infarction (MI) results in 3 distinct regions within the left ventricle:
The infarct zone, the border zone (BZ), and the remote zone. A major focus of MI research.
Is investigating the intrinsic mechanisms in the BZ to alleviate myocardial injury.
USP10 (ubiquitin-specific peptidase 10) expression is reduced in BZ cardiomyocytes.
Teaching NeuroImages: Sacral Dural Arteriovenous Fistula With Supply From Bilateral Lateral Sacral Arteries
Teaching NeuroImages case: A 51-year-old man presented with a 3-month history of progressive lower extremity weakness and numbness, starting distally and progressing proximally, accompanied by mild gait difficulty but no bowel/bladder symptom. Read the full case.
Download PDF and Supplementary Material Download is in progress.
A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells
Danièle Stalder, Conceição Pereira, David C. Gershlick et al. (University of Cambridge) uncover new regulators of Golgi-to-plasma membrane transport, showing that a PTPN23-dependent ESCRT pathway is essential for secretion of membrane & soluble cargoes, including hormones & antibodies.
Stalder and Pereira et al. combine affinity isolation of post-Golgi carriers, mass spectrometry, and a pooled CRISPR-KO screen to uncover new regulators of.
New DNA base editor minimizes bystander edits while maintaining high efficiency
The trajectory of base editing has been remarkable, progressing from the laboratory to patient care, treating debilitating or terminal illnesses, in less than a decade. A type of gene editing that makes chemical changes to our DNA, base editing was developed by Alexis Komor, associate professor in the Department of Biochemistry and Molecular Biophysics at the University of California San Diego.
For all of base editing’s success, it is still a relatively new technology, and researchers like Komor are working to improve its efficiency, while lowering the incidence of unwanted edits. One type of unwanted edit is called a bystander edit. This occurs when a base editor not only edits the desired nucleobase, but also edits surrounding bases as well. Komor’s lab has developed a way to minimize bystander edits. This work appears in Nature Biotechnology.