Lifeboat Foundation

Discover cosmic enigmas: Ohio State’s study on neutrinos and supernovae unveils new insights into the universe’s hidden interactions.

Human thrombin. Thrombin is the enzyme responsible for bleeding and for blood clotting, depending on how it’s activated, and has two DNA drug-binding sites. ©2023 Yoshimoto et al. CC-BY

Various medical circumstances, including heart attacks and extreme cases of COVID-19, necessitate the use of anticoagulants, medicines that prevent blood clots. But the most commonly used, heparin, can induce potentially fatal side effects by making the blood clots worse rather than better. This only happens in a minority of patients so effective treatments are not commonly explored. For the first time, researchers, including those from the University of Tokyo, have proposed a side effect-free anticoagulating treatment that has so far proved effective in test mice and could be ready for human trials in just a few years.

The COVID-19 pandemic brought much woe to people around the world. And at the time of writing, though much of the world seems to have moved on, the effects of the pandemic continue to linger. One aspect of some extreme cases of COVID-19 that has not been widely reported is the complication brought on when the anticoagulant medicine heparin is used in an attempt to reduce blood clots in patients. A small number — up to 3% of recipients — suffer the side effect heparin-induced thrombocytopenia (HIT), a potentially fatal and rapid clotting of the blood, the opposite of the intended effect. Other medical issues, such as heart attacks, kidney dialysis, and even some surgeries, can also require anticoagulants.

The era of mainframe computers and directly programming machines with switches is long past, but plenty of us look back on that era with a certain nostalgia. Getting that close to the hardware and knowing precisely what’s going on is becoming a little bit of a lost art. That’s why [Phil] took it upon himself to build this homage to the mainframe computer of the 70s, which all but disappeared when PCs and microcontrollers took over the scene decades ago.

The machine, known as PlasMa, is not a recreation of any specific computer but instead looks to recreate the feel of computers of this era in a more manageable size. [Phil] built the entire machine from scratch, and it can be programmed directly using toggle switches to input values into registers and memory. Programs can be run or single-stepped, and breakpoints can be set for debugging. The internal workings of the machine, including the program counter, instruction register, accumulator, and work registers, are visible in binary lights. Front panel switches let you control those same items.

The computer also hosts three different microcodes, each providing a unique instruction set. Two are based on computers from Princeton, Toy-A, and Toy-B, used as teaching tools. The third is a more advanced instruction set that allows using things like emulated peripherals, including storage devices. If you want to build one or just follow along as the machine is constructed, programmed, and used, [Phil] has a series of videos demonstrating its functionality, and he’s made everything open-source for those more curious. It’s a great way to get a grasp on the fundamentals of computing, and the only way we could think of to get even more into the inner workings of a machine like this is to build something like a relay computer.

You may have heard of light as both particles and waves, but have you ever imagined the secret dance within? Researchers from the University of Ottawa and Sapienza University in Rome have just uncovered a groundbreaking technique that enables the real-time visualization of the wave function of entangled photons — the fundamental components of light.

Imagine choosing a random shoe from a pair. If it’s a “left” shoe, you immediately know the other shoe you’ve yet to unbox is meant to go on your right foot. This instantaneous information is certain whether the shoe box is within hand’s reach or 4.3 light-years away on some planet in the Alpha Centauri system.

This analogy, though not perfect, captures the essence of quantum entanglement. At its core, quantum entanglement refers to the phenomenon where two or more particles become deeply interconnected in such a way that their properties become correlated, regardless of the spatial separation between them. This means that the state of one particle instantly influences the state of another, even if they are light-years apart.

“The invention, which cooks cylinder-shaped pizzas and other foods, recently moved on to the final phase of NASA’s Deep Space Food Challenge.”

The invention, which cooks cylinder-shaped pizzas and other foods, is now being adjusted for zero-gravity with the help of BioServe Space Technologies.

Elon Musk-owned X, formerly Twitter, is planning to roll out a new way to display news links without any headline or description. The social network will display just the link and the header image in a post, according to a report by Fortune.

Musk confirmed the move in a post on Monday and said it was coming “directly” from him. The change would “greatly improve the aesthetics,” he said.

This is coming from me directly. Will greatly improve the esthetics.

New tools use artificial intelligence to assist students with autism and dyslexia and address accessibility for those who are blind or deaf.

Researchers headed by a team at Mass Eye and Ear, Harvard Medical School, reported positive data from a Phase I clinical study evaluating a stem cell treatment known as cultivated autologous limbal epithelial cell transplantation (CALEC), in patients with significant chemical burns in one eye. Results from the study, reported in Science Advances, showed treatment to be safe and well tolerated in four patients who were followed for 12 months. The CALEC recipients experienced restored cornea surfaces, with two trial participants able to undergo subsequent corneal transplant, and two reporting significant improvements in vision without additional treatment.

The Phase I study was designed to determine preliminary safety and feasibility before advancing to a second phase of the trial, and the researchers consider the newly reported early findings to be promising. On the basis of these initial results the team started recruiting for a second phase of the trial that will investigate longer-term safety and efficacy in greater numbers of patients.

“Our early results suggest that CALEC might offer hope to patients who had been left with untreatable vision loss and pain associated with major cornea injuries,” said principal investigator Ula Jurkunas, MD, associate director of the Cornea Service at Mass Eye and Ear and an associate professor of ophthalmology at Harvard Medical School. “Cornea specialists have been hindered by a lack of treatment options with a high safety profile to help our patients with chemical burns and injuries that render them unable to get an artificial cornea transplant. We are hopeful with further study, CALEC can one day fill this crucially needed treatment gap.”

Talk with Your Allergy Care Team About Your Concerns.

If managing the social and emotional impacts of your atopic condition feels stressful and overwhelming, know that you’re not alone. More importantly, know that you don’t have to navigate those feelings alone either!

Your allergy healthcare team is a great place to start if you feel like you need additional support in managing your allergic condition. By discussing your concerns or struggles with them, they can offer useful evidence-based information, skills, and resources, as well as allied health care referrals.