Lifeboat Foundation

Pancreatic ductal adenocarcinoma (PDAC) presents as an unmet clinical challenge for drug delivery due to its unique hypoxic biology. Vinblastine-N-Oxide (CPD100) is a hypoxia-activated prodrug (HAP) that selectively converts to its parent compound, vinblastine, a potent cytotoxic agent, under oxygen gradient. The study evaluates the efficacy of microfluidics formulated liposomal CPD100 (CPD100Li) in PDAC. CPD100Li were formulated with a size of 95 nm and a polydispersity index of 0.2. CPD100Li was stable for a period of 18 months when freeze-dried at a concentration of 3.55 mg/mL. CPD100 and CPD100Li confirmed selective activation at low oxygen levels in pancreatic cancer cell lines. Moreover, in 3D spheroids, CPD100Li displayed higher penetration and disruption compared to CPD100.

For as long as we’ve been around, human beings have fought against the inevitability of death. This struggle has given rise to religions that have dominated human culture for millennia and has been central to philosophies that have shaped our civilizations.

But might it be the case that a scientific solution to immortality is finally in sight? In recent years, artificial intelligence (AI) has evolved to the stage where it looks set to revolutionize every aspect of our lives. It may just be possible that it’s going to change the way that we think about – and perhaps even experience – death, too.

Science fiction has given us several examples of situations – mostly horrific — where human minds can be uploaded to machines, effectively allowing us to outlast our mortal, fallible bodies.

Summary: Scientists have discovered a direct link between the protein p53 and autism-like behavior in mice. The researchers studied the effects of manipulating p53 levels in the mouse hippocampus.

Reduced levels resulted in repetitive behavior, diminished sociability, and impaired learning, especially in male mice. This pivotal work uncovers the intricate role of p53 in neurodevelopmental disorders like autism.

With office spaces being emptier, companies are using WiFi access points and AI sensors to learn about employees’ behavior in the workplace.

Startup Light Bio has created a bioluminescent petunia using mushroom genes and plans to start shipping the plants next spring.

Founded in 2021, Virginia-based Procyon Photonics is a startup aiming to change the future of computing hardware with its focus on optical computing. What makes the company unique is that their entire team consists of current high school students, and its co-founder, CEO, and CTO, Sathvik Redrouthu, holds the distinction of being the world’s youngest CEO in the photonic and optical computing sector.

Optical computing represents an innovative leap from traditional computing, which relies on electrons moving through wires and transistors. Instead, this relatively nascent field seeks to harness photons — particles of light — as the fundamental elements in computational processes. The promise of optical computing is compelling enough that industry giants like IBM and Microsoft, among others, are heavily investing in its research and development.

Procyon is attempting to differentiate itself in this competitive landscape not just by its youth, but with their technology. The team is pioneering a unique, industry-leading optical chip, and has published a conference paper detailing how a specialized form of matrix algebra could be executed on an optoelectronic chip.

University of Washington researchers are rolling out another tiny robotic breakthrough, this time in the form of an autonomous device that relies on surrounding light or radio waves to move in short bursts.

The robot, dubbed MilliMobile, is about the size of a penny and weighs as much as a raisin, and a typical power source, such as a battery, has been kicked to the curb in favor of more environmentally friendly approach.

MilliMobile has a solar panel-like energy harvester that sits above four tiny wheels, enabling the robot to roll — in incremental steps — about the 30 feet in an hour across surfaces such as concrete or packed soil.

The International Space Weather Initiative (ISWI) promoted space weather research and serves as a testament to remarkable international cooperation.

If the hypothesis that misfolded proteins start in the gut and travel to the brain is proved, it could lead to early detection and treatment of Parkinson’s.