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Apr 22, 2024

Queensland Brain Institute

Posted by in categories: biotech/medical, neuroscience

News stories, articles and whitepapers referencing Queensland Brain Institute on Drug Target Review.

Apr 22, 2024

Optimising CRISPR gene editing of hard-to-transfect cells

Posted by in categories: bioengineering, biotech/medical

CRISPR has transformed gene editing, but still presents challenges in hard-to-transfect cells, such as pluripotent stem cells and primary cells.1 The key to obtaining successful transfection in these cells lies in innovative workflows. Here Georges Müller, CEO and cofounder of SEED Biosciences, shares his perspective on why focusing on editing a single cell, rather than bulk cells, is a pivotal strategy to optimise CRISPR delivery.

Delivery of ribonucleoprotein (RNP) into cells is an essential factor for successful CRISPR gene editing. However, this is difficult to guarantee using traditional CRISPR gene editing methods, especially in hard-to-transfect cells. The standard CRISPR technique involves gathering a group of cells and then electroporating them, using short high-voltage pulses to overcome the barrier of their cell membranes. This allows bulk transfection of ribonucleoprotein (RNP) into the cells and then hopefully, nuclear translocation.

Apr 22, 2024

The Ins and Outs of Single Cell Gene Editing (Sponsored by Molecular Devices)

Posted by in categories: bioengineering, biotech/medical

In this special episode, we’re joined by Cytosurge CSO Tobias Beyer, Ph.D., and SEED Biosciences CEO and Co-Founder Georges Muller, Ph.D., for an overview of gene editing with Cytosurge’s FluidFM® in combination with DispenCell™ dispensing technologies.

Tobias and Georges explain the FluidFM® technique and how it differs from traditional CRISPR methods along with the advantages the technology has over other methods of gene editing.

Continue reading “The Ins and Outs of Single Cell Gene Editing (Sponsored by Molecular Devices)” »

Apr 22, 2024

Molecular Devices

Posted by in category: futurism

We are one of the leading providers of high-performance bioanalytical measurement solutions for life science research, pharmaceutical and biotherapeutic development. Our products enable scientists to improve productivity and efficiency in scientific disco.

Apr 22, 2024

SpaceX’s Upcoming Starship Launch Schedule and FAA Approval Update

Posted by in categories: security, space travel

SpaceX is preparing for upcoming Starship launches and is working on upgrading launch support infrastructure, but still needs FAA approval for the new launch schedule.

Questions to inspire discussion.

Continue reading “SpaceX’s Upcoming Starship Launch Schedule and FAA Approval Update” »

Apr 22, 2024

‘Nano stitches’ enable lighter and tougher composite materials

Posted by in categories: energy, transportation

To save on fuel and reduce aircraft emissions, engineers are looking to build lighter, stronger airplanes out of advanced composites. These engineered materials are made from high-performance fibers that are embedded in polymer sheets. The sheets can be stacked and pressed into one multilayered material and made into extremely lightweight and durable structures.

Apr 22, 2024

Scientists grow human mini-lungs as animal alternative for nanomaterial safety testing

Posted by in category: nanotechnology

Human mini-lungs grown by University of Manchester scientists can mimic the response of animals when exposed to certain nanomaterials. The study is published in Nano Today.

Apr 22, 2024

Meet QDEL, the backlight-less display tech that could replace OLED in premium TVs

Posted by in categories: computing, quantum physics

Quantum dots are already moving in the premium display category, particularly through QD-OLED TVs and monitors. The next step could be QDEL, short for “quantum dot electroluminescent,” also known as NanoLED, screens. Not to be confused with the QLED (quantum light emitting diode) tech already available in TVs, QDEL displays don’t have a backlight. Instead, the quantum dots are the light source. The expected result is displays with wider color spaces than today’s QD-OLEDs (quantum dot OLEDs) that are also brighter, more affordable, and resistant to burn-in.

It seems like QDEL is being eyed as one of the most potentially influential developments for consumer displays over the next two years.

If you’re into high-end display tech, QDEL should be on your radar.

Apr 22, 2024

NVIDIA To Collaborate With Japan On Their Cutting-Edge ABCI-Q Quantum Supercomputer

Posted by in categories: quantum physics, robotics/AI, supercomputing

NVIDIA is all set to aid Japan in building the nation’s hybrid quantum supercomputer, fueled by the immense power of its HPC & AI GPUs.

Japan To Rapidly Progressing In Quantum and AI Computing Segments Through Large-Scale Developments With The Help of NVIDIA’s AI & HPC Infrastructure

Nikkei Asia reports that the National Institute of Advanced Industrial and Technology (AIST), Japan, is building a quantum supercomputer to excel in this particular segment for prospects. The new project is called ABCI-Q & will be entirely powered by NVIDIA’s accelerated & quantum computing platforms, hinting towards high-performance and efficiency results out of the system. The Japanese supercomputer will be built in collaboration with Fujitsu as well.

Apr 22, 2024

Discovery of How to Limit Asthma Attack Damage could Stop Disease

Posted by in category: biotech/medical

Scientists at King’s College London have discovered a new cause for asthma that sparks hope for treatment that could prevent the life-threatening disease.

Most current asthma treatments stem from the idea that it is an inflammatory disease. Yet, the life-threatening feature of asthma is the attack or the constriction of airways, making breathing difficult. The new study, published in Science, shows for the first time that many features of an asthma attack—inflammation, mucus secretion, and damage to the airway barrier that prevents infections—result from this mechanical constriction in a mouse model.

The findings suggest that blocking a process that normally causes epithelial cell death could prevent the damage, inflammation, and mucus that result from an asthma attack.

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