Calcium influx through CRAC channels requires STIM1 binding to Orai1. Using crosslinking and mutagenesis, Söllner et al. show that widening the nexus-TM3 interface near the STIM1 coupling site is crucial for channel opening, while hydrophobicity and charges support signal transmission to the pore. Nexus-TM3 dynamics are vital for Orai1 function.
Ráez-Meseguer, C., Navas-Enamorado, C., Capó, X. et al. MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan. npj Aging 12, 30 (2026). https://doi.org/10.1038/s41514-025-00321-1
Aarhus University chemist Troels Skrydstrup and his team recently debuted their efforts to turn nitrile rubber, of the kind used in laboratory and medical gloves, into polyamine membranes that sequester carbon dioxide.
Chemists upcycle nitrile rubber into carbon-sequestering polyamines by Brianna Barbu.
Among over 7,000 patients with cancer, higher baseline fatigue before systemic therapy was linked to an increased risk of severe, life-threatening, and fatal adverse events.
Question Is baseline patient-reported fatigue associated with subsequent cancer treatment−related adverse events?
Findings In this cohort study and pooled analysis of 7,086 patients from 17 SWOG phase 2 and 3 randomized clinical trials, patients who reported baseline fatigue had a significantly higher risk of severe, life-threatening, and fatal adverse events. In addition, a dose-response pattern was observed, with patients reporting high fatigue vs no fatigue having a nearly 5-fold increased risk of fatal toxic effects.
Meaning Patient fatigue reported before cancer treatment may serve as an early clinical marker of risk for toxic effects and could help guide personalized treatment strategies.
Anyone interested in the morality of suicide reads David Hume’s essay on the subject even today. There are numerous reasons for this, but the central one is that it sets up the starting point for contemporary debate about the morality of suicide, namely, the debate about whether some condition of life could present one with a morally acceptable reason for autonomously deciding to end one’s life. We shall only be able to have this debate if we think that at least some acts of suicide can be moral, and we shall only be able to think this if we give up the blanket condemnation of suicide that theology has put in place. I look at this strategy of argument in the context of the wider eighteenth-century attempt to develop a non-theologically based ethic. The result in Hume’s case is a very modern tract on suicide, with voluntariness and autonomy to the fore and with reflection on the condition of one’s life and one’s desire to carry on living a life in that condition the motivating circumstance.
The release of the 2026 dark matter map marks a definitive shift in how we approach the cosmos. For decades, we were in the hunting phase, trying to prove that dark matter existed and attempting to catch a single particle in a laboratory. While we still haven’t touched a dark matter particle, we have moved into the surveying phase. We are no longer asking if it is there; we are busy measuring its dimensions, its density, and its influence on the growth of everything we can see. This map of the Sextans field is essentially the first page in a new atlas of the invisible universe.
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Timestamps:
0:00 Dark Matter.
1:05 The Cosmic Lens.
4:20 The COSMOS-Web Survey.
7:15 Mapping the Filaments.
10:22 Beyond the Standard Model.
13:15 The Architect of Life.
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Fexl Spanish: / @fexl_es.
Fexl Portuguese: / @fexlpt.
Fexl Ukraine: / @fexl_ua.
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References:
Nature Astronomy (January 2026): An ultra-high-resolution map of (dark) matter: https://www.nature.com/articles/s4155… Pre-print (Technical Breakdown): COSMOS-Web: The ultra-deep weak lensing survey: https://arxiv.org/abs/2601.17239 NASA Webb Mission Page: Webb Unveils the Dark Matter Scaffolding of the Universe: https://www.nasa.gov/missions/webb/na… COSMOS-Web Collaboration Official Site: https://cosmos.astro.caltech.edu/ NASA JPL Press Release: Seeing the Unseen: 800,000 Galaxies Mapped: https://www.jpl.nasa.gov/news/nasa-re… #fexl #space #jwst.
ArXiv Pre-print (Technical Breakdown): COSMOS-Web: The ultra-deep weak lensing survey: https://arxiv.org/abs/2601.
In this episode of MythVision, we dive into one of the most intense debates in New Testament textual criticism.
If we have more manuscripts of the New Testament than any other ancient book — why do scholars estimate up to 500,000 textual variants?
Are we actually close to the original text?
Do the Gospels contradict each other?
Do these differences matter — or are they just minor copying mistakes?
In this discussion we explore:
The “embarrassment of riches” argument.
The variant reading “Today I have begotten you” (Luke 3:22)
#jameswebbspacetelescope #jwst.
Finally Released! The James Webb Telescope Has Found The Object That Holds Our Universe Together.
Containing nearly 800,000 galaxies, this image from NASA’s James Webb Space Telescope is overlaid with a map of dark matter, represented in blue. Researchers used Webb data to find the invisible substance via its gravitational influence on regular matter.
You see, Scientists using data from NASA’s James Webb Space Telescope have made one of the most detailed, high-resolution maps of dark matter ever produced. It shows how the invisible, ghostly material overlaps and intertwines with “regular” matter, the stuff that makes up stars, galaxies, and everything we can see.
Published Monday, Jan. 26, in Nature Astronomy, the map builds on previous research to provide additional confirmation and new details about how dark matter has shaped the universe on the largest scales — galaxy clusters millions of light-years across — that ultimately give rise to galaxies, stars, and planets like Earth.
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In people with elevated cardiovascular risk at baseline, adherence to the Mediterranean and Mediterranean-DASH Diet Intervention for Neurodegenerative Delay diets was associated with a lower risk of stroke.
BACKGROUND: Adherence to healthy dietary patterns has been related to lower cardiovascular disease risk. However, few studies have examined prospective associations between adherence to different healthy dietary scores and the incidence of stroke and its subtypes. The aim of this study was to prospectively examine the associations between adherence to 4 recognized healthy dietary patterns and the risk of total and ischemic stroke in an existing dietary-based randomized controlled trial. METHODS: This is a secondary observational cohort analysis of 7,447 participants at high cardiovascular disease risk enrolled in the PREDIMED trial (Prevención Con Dieta Mediterranea).