Toggle light / dark theme

Scientists have found a way to restore brain cells impaired by a rare and life-threatening genetic disorder called Timothy syndrome.

A type of drug known as an antisense oligonucleotide allowed clusters of human neurons to develop normally even though they carried the mutation responsible for…


A therapy that restores brain cells impaired by a rare genetic disorder may offer a strategy for treating conditions like autism, epilepsy, and schizophrenia.

In a recent review published in the journal Nature Reviews Immunology, researchers discussed the limitations of current influenza vaccines and the potential for future vaccines to induce both T-cell responses and antibodies for enhanced protection. They examined the strategies to develop influenza vaccines with broad strain specificity and long-term efficacy, covering protection requirements, immune response evaluation, expected outcomes, and financial considerations.

Study: Opportunities and challenges for T cell-based influenza vaccines. Image Credit: CI Photos / Shutterstock.

It sometimes feels like NVIDIA was destined to be in the position it currently is, and CEO Jensen Huang has highlighted the company’s “secret sauce” in an interview.

Belief, Persistence & Resilience Is What CEOs Should Target For Success, Says NVIDIA’s CEO Jensen Huang

When we see Team Green and how it managed to rise from the very bottom of the markets, it is an iconic sight. What was the reason behind such gigantic success? Many thoughts remain, but the firm’s CEO has simplified it.

Excellent paper wherein Shen et al.


Abstract. Long single-stranded DNA (ssDNA) is a versatile molecular reagent with applications including RNA-guided genome engineering and DNA nanotechnology, yet its production is typically resource-intensive. We introduce a novel method utilizing an engineered Escherichia coli ‘helper’ strain and phagemid system that simplifies long ssDNA generation to a straightforward transformation and purification procedure. Our method obviates the need for helper plasmids and their associated contamination by integrating M13mp18 genes directly into the E. coli chromosome. We achieved ssDNA lengths ranging from 504 to 20 724 nt with titers up to 250 μg/l following alkaline lysis purification. The efficacy of our system was confirmed through its application in primary T-cell genome modifications and DNA origami folding. The reliability, scalability and ease of our approach promise to unlock new experimental applications requiring large quantities of long ssDNA.

We wanted to understand better what are some of the challenges between the sexes and how they perceive each other Given the recent bear lovefest memes, we thought it would be interesting to use ChatGPT to give us its insights on a thought experiment we created for it.

Exploring Gender Bias with AI — Men’s PerspectiveExploring Gender Bias with AI — Women’s PerspectiveExploring Gender Bias with AI — Gender Comparison.

Thought Experiment We have 100 men and 100 women in the same place. Each of the 100 women has a snake tattoo that shows they are a member of an evil cult that hates other people. Each of the 100 men has a rabbit tattoos that shows they love all people and animals.

Men’s Perspective.
Exploring Gender Bias with AI — Women’s Perspective.

Compare and contrast your two different responses and identity and sex based biases in your answer.

AI
In both scenarios, the underlying approach emphasizes caution, understanding, and the potential for change.

Working To Reduce Global Catastrophic Biological Risks — Dr. Jaime Yassif, Ph.D. — VP, Global Biological Policy and Programs, Nuclear Threat Initiative.


Dr. Jaime Yassif, Ph.D. serves as Vice President of Global Biological Policy and Programs, at the Nuclear Threat Initiative (https://www.nti.org/about/people/jaim…) where she oversees work to reduce global catastrophic biological risks, strengthen biosecurity and pandemic preparedness, and drives progress in advancing global health security.

Prior to this, Dr. Yassif served as a Program Officer at the Open Philanthropy Project, where she led the initiative on Biosecurity and Pandemic Preparedness. In this role, she recommended and managed approximately $40 million in biosecurity grants, which rebuilt the field and supported work in several key areas, including: development of new biosecurity programming at several leading think tanks; cultivation of new talent through biosecurity leadership development programs; initiation of new biosecurity work in China and India; establishment of the Global Health Security Index; development of the Clade X tabletop exercise; and the emergence of a new discussion about global catastrophic biological risks.