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By exerting ‘crowd control’ over mouse cells, scientists make progress towards engineering tissues

Genes aren’t the sole driver instructing cells to build multicellular structures, tissues, and organs. In a paper published in Nature Communications, USC Stem Cell scientist Leonardo Morsut and Caltech computational biologist Matt Thomson characterize the influence of another important developmental driver: cell density, or how loosely or tightly cells are packed into a given space.

In both computational models and laboratory experiments, the team of scientists used cell density as an effective tool for controlling how pattern themselves into complex structures.

“This paper represents progress towards our big picture goal of engineering synthetic tissues,” said Morsut, an assistant professor of stem cell biology and regenerative medicine, and biomedical engineering at the Keck School of Medicine of USC.

Human Cell Atlas Transforms Understanding of Disease

Summary: The Human Cell Atlas (HCA) consortium has published over 40 studies revealing groundbreaking insights into human biology through large-scale mapping of cells. These studies cover diverse areas such as brain development, gut inflammation, and COVID-19 lung responses, while also showcasing the power of AI in understanding cellular mechanisms.

By profiling over 100 million cells from 10,000 individuals, HCA is building a “Google Maps” for cell biology to transform diagnostics, drug discovery, and regenerative medicine. The initiative emphasizes diversity, including underrepresented populations, to ensure a globally inclusive understanding of health and disease.

Gene Repair Restores Brain Signal Efficiency in Autism

Summary: Autism-linked SHANK3 gene mutations disrupt not only neurons but also oligodendrocytes, essential for producing myelin, which insulates nerve fibers. This damage reduces brain signal efficiency and impairs behavior.

Using gene therapy, researchers successfully repaired these cells in a mouse model, restoring their function and myelin production. They validated their findings with human-derived stem cells, confirming similar impairments and repair mechanisms.

This discovery highlights a significant role for oligodendrocytes in autism and opens the door for innovative treatments targeting myelin dysfunction. The study underscores both the biological complexity of autism and the promise of genetic therapies for intervention.

AlphaQubit tackles one of quantum computing’s biggest challenges

AlphaQubit: an AI-based system that can more accurately identify errors inside quantum computers.


AlphaQubit is a neural-network based decoder drawing on Transformers, a deep learning architecture developed at Google that underpins many of today’s large language models. Using the consistency checks as an input, its task is to correctly predict whether the logical qubit — when measured at the end of the experiment — has flipped from how it was prepared.

We began by training our model to decode the data from a set of 49 qubits inside a Sycamore quantum processor, the central computational unit of the quantum computer. To teach AlphaQubit the general decoding problem, we used a quantum simulator to generate hundreds of millions of examples across a variety of settings and error levels. Then we finetuned AlphaQubit for a specific decoding task by giving it thousands of experimental samples from a particular Sycamore processor.

When tested on new Sycamore data, AlphaQubit set a new standard for accuracy when compared with the previous leading decoders. In the largest Sycamore experiments, AlphaQubit makes 6% fewer errors than tensor network methods, which are highly accurate but impractically slow. AlphaQubit also makes 30% fewer errors than correlated matching, an accurate decoder that is fast enough to scale.

Sam Altman “Level 4 Innovator is MUCH closer” | PLUS “Unsupervised Sentiment Neuron” breakthrough

The latest AI News. Learn about LLMs, Gen AI and get ready for the rollout of AGI. Wes Roth covers the latest happenings in the world of OpenAI, Google, Anthropic, NVIDIA and Open Source AI.

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The original interview: • how to build the future: sam altman

Free Biological Age Calculator

We converted the calculations in Morgan Levine and Steve Horvath’s famous research paper on phenotypic age into a free biological age calculator.

It’s a great (cheap) alternative to $400 epigenetic age tests and means you can test more frequently to see if longevity interventions are actually…


This free biological age calculator is based on a pioneering paper by longevity experts Dr. Morgan Levine and Dr. Steve Horvath.

The paper, titled “An epigenetic biomarker of aging for lifespan and healthspan,” used some super-advanced machine learning techniques to find blood biomarkers which are significantly correlated with aging-related health outcomes, including mortality.

Essentially, they are able to use the results from this test to predict how near (or far away) you are from death.

Brain circuitry changes linked to therapeutic success in depression treatment

Can therapy rewire the brain? For individuals struggling with both depression and obesity, a new Stanford Medicine study says yes—when the therapy is the right fit. Researchers found that cognitive behavioral therapy focused on problem-solving reduced depression symptoms in a third of participants and altered their brain activity in ways that could predict longer-term benefits. The findings have been published in Science Translational Medicine.

Depression affects millions of people worldwide and becomes particularly challenging to treat when paired with obesity, a condition that complicates recovery and worsens outcomes. Previous research has suggested that brain regions associated with cognitive control—areas responsible for regulating emotions and behaviors—might influence how individuals respond to therapy.

This study aimed to determine whether a therapy specifically designed to engage these brain circuits could lead to sustained improvements in depression symptoms, particularly in individuals with comorbid depression and obesity. The researchers also investigated whether early changes in brain activity could predict long-term therapeutic success, paving the way for more personalized treatment strategies.

TSMC 2nm Process Is Right On-Track, Slated For Mass-Production By 2025 & Sees “All-Time” High Demand

TSMC is set to mass-produce its cutting-edge 2nm process by 2025, as the Taiwan giant is seeing massive interest from companies such as Apple and NVIDIA.

TSMC’s 2nm Node Is Said To Replace All Others When It Comes To Revenue Generation, Amid Gigantic Demand From The Markets

TSMC’s upcoming 2nm node is said to be a revolution for the tech markets, given that it has pledged to bring in significant performance uplifts, one that will aid in speeding up the computational capabilities of devices across the industry.