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Does suppression of HIV replication protect against severe M

tuberculosis infection?

Philana Ling Lin & team report on SIV/ART/TB models, finding antiretroviral treatment reduces pulmonary TB pathology, yet does not prevent extrapulmonary spread of TB.

1Department of Pediatrics, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

2Center for Vaccine Research.

3Department of Microbiology and Molecular Genetics, and.

4Division of Laboratory Animal Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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PDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer

GUTImage from the paper by Wang et al entitled.

via.

https://bit.ly/4ae9wtW

GastricCancer.

Background Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) in GC.

Objective Identifying a critical subpopulation of CAFs in promoting an immunosuppressive TME and enabling immune evasion, which may influence therapeutic effectiveness of immune checkpoint inhibitors (ICIs) for GC.

Continue reading “PDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer” | >

Standardization Versus Adaptability: Where Is the Sweet Spot?

New in practicalRO.

Standardization in clinical workflows is widely recognized as a driver of safety, efficiency, and consistency. The challenge for modern practice is determining the appropriate degree and rigidity of standardization, especially as automation and adaptive technologies reshape workflows.

🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI

Editor’s note: raised a $100m Series A in September and is rumored to have reached a unicorn valuation. They have all-star advisors from Geoff Hinton to Yann Lecun and team of deep domain experts to tackle this next frontier in AI applications.

Major battery breakthrough paving way for EV upgrade

Chinese scientists have developed a lithium metal battery that boasts an energy density of more than 700 watt-hours per kilogram and stable performance at extremely low temperatures, marking a significant advancement in the production of high-energy batteries for electric vehicles. The research paper was published on Thursday in the science journal Nature.

Chen Jun, an academician of the Chinese Academy of Sciences and vice-president of Nankai University in Tianjin, was among the researchers who led the breakthrough. Chen said the team has replaced oxygen atoms with fluorine ones. It designed and synthesized novel fluorinated hydrocarbon solvent molecules, creating a new electrolyte system based on lithium-fluorine coordination.

The 5 Foods Every 100-Year-Old Ate Daily (Blue Zones Diet Breakdown)

The controversial diet truth backed by 155 dietary surveys across 90 years that food scientists don’t want you to know.

Dan Buettner exposes why meta-analyses prove most nutritional debates wrong and reveals what centenarians actually ate as children to live past 100.

The peasant food formula that’s cheaper than a hamburger, 50 times more nutrient dense, and leaves you completely satisfied.

Plus why the 15 countries with the highest life expectancy all eat white rice daily.

Dan Buettner is a New York Times bestselling author, National Geographic Fellow, and co-producer of the Emmy Award winning Netflix series Live to 100: Secrets of the Blue Zones.

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