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GCC19CART has previously been evaluated in an investigator-initiated clinical trial (ChiCTR2000040645) in China for the treatment of relapsed/refractory metastatic colorectal cancer (r/r mCRC).2 Data from that trial showing improvements over standard of care (SOC) third-line therapies were presented at the American Association for Cancer Research (AACR) Annual Meeting 2023, held April 14–19, 2023, in Orlando, Florida. Among the 21 patients included in the efficacy analysis, superior results were observed in patients (n=8) who received the higher dose level (2×106 CAR-T cells/kg; DL2) than in patients (n=13) who received the lower dose level (1×106 CAR-T cells/kg; DL1). The objective response rate was 50% (n=4) for DL2, 15% (n=2) for DL1, and 29% (n=6) for all patients.

“The new AE specific to this product is diarrhea because the target is guanylate cyclase 2C (GCC), which plays a role in intestinal homeostasis… So, that’s expected, theoretically,” Victor Lu, PhD, the chief technology officer of Innovative Cellular Therapeutics, who presented the data, said during his presentation.2 “Most patients treated with this product experienced diarrhea, but it can be controlled and because of the diarrhea management most of the patients actually recovered very quickly.”

GCC19CART targets both GCC and CD19.1 It was designed using ICT’s CoupledCAR platform, which combines 2 CAR T cells engineered to release cytokines that are thought to promote proliferation and infiltration.3 The platform was designed following observations that CD19-directed CAR T cells also stimulated the immune system, which could lead to increase proliferation for other CAR T cells, specifically those directed toward solid tumor antigens, like GCC.

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Researchers in China have demonstrated how entanglement might potentially power future generations of computers, according to a story in the South China Morning Post. This advance, achieved by scientists from the Chinese Academy of Sciences’ Innovation Academy of Precision Measurement Science and Technology, points toward how quantum engines can use their own entangled states as a form of fuel.

Entanglement is a quantum phenomenon where a pair of separated photons seem to be intimately linked, regardless of the distance between them. Scientists have long theorized that this characteristic, once robustly managed, could hold vast potential for quantum computing, and this study adds further evidence to its viability in practical applications, the researchers suggest.

“Our study’s highlight is the first experimental realization of a quantum engine with entangled characteristics. [It] quantitatively verified that entanglement can serve as a type of ‘fuel’,” said Zhou Fei, one of the corresponding authors, as reported in the SCMP.

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There’s a hot new BEC in town that has nothing to do with bacon, egg, and cheese. You won’t find it at your local bodega, but in the coldest place in New York: the lab of Columbia physicist Sebastian Will, whose experimental group specializes in pushing atoms and molecules to temperatures just fractions of a degree above absolute zero.

Writing in Nature (“Observation of Bose-Einstein Condensation of Dipolar Molecules”), the Will lab, supported by theoretical collaborator Tijs Karman at Radboud University in the Netherlands, has successfully created a unique quantum state of matter called a Bose-Einstein Condensate (BEC) out of molecules.

Their BEC, cooled to just five nanoKelvin, or about-459.66 F, and stable for a strikingly long two seconds, is made from sodium-cesium molecules. Like water molecules, these molecules are polar, meaning they carry both a positive and a negative charge. The imbalanced distribution of electric charge facilitates the long-range interactions that make for the most interesting physics, noted Will.

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Physicists at Columbia University have taken molecules to a new ultracold limit and created a state of matter where quantum mechanics reigns.

There’s a hot new BEC in town that has nothing to do with bacon, egg, and cheese. You won’t find it at your local bodega, but in the coldest place in New York: the lab of Columbia physicist Sebastian Will, whose experimental group specializes in pushing atoms and molecules to temperatures just fractions of a degree above absolute zero.

Writing in Nature, the Will lab, supported by theoretical collaborator Tijs Karman at Radboud University in the Netherlands, has successfully created a unique quantum state of matter called a Bose-Einstein Condensate (BEC) out of molecules.

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It’s possible that our universe is the antimatter counterpart of an antimatter universe that existed earlier in time than the Big Bang. So claim physicists in Canada, who have devised a new cosmological model positing the existence of a “antiuniverse” which, paired to our own, preserves a fundamental rule of physics called CPT symmetry. Though many details in their theory still need to be worked out, the researchers claim that it naturally explains the existence of dark matter.

According to standard cosmological models, the universe—which consists of space, time, and mass/energy—exploded into being about 14 billion years ago. Since then, it has expanded and cooled, causing subatomic particles, atoms, stars, and planets to gradually form.

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Go to https://hensonshaving.com/isaacarthur and enter “isaacarthur” at checkout to get 100 free blades with your purchase. Ganymede is an enormous moon, larger than any other we’ve found, including our own, and may one day be the centerpiece of wider human settlements around Jupiter. Visit our Website: http://www.isaacarthur.net Join Nebula: https://go.nebula.tv/isaacarthur Support us on Patreon: / isaacarthur Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Group: / 1,583,992,725,237,264 Reddit: / isaacarthur Twitter: / isaac_a_arthur on Twitter and RT our future content. SFIA Discord Server: / discord Credits: Colonizing Ganymede Episode 449; May 30, 2024 Written, Produced & Narrated by: Isaac Arthur Graphics: Jeremy Jozwik Kristijan Tavcar Rapid Thrash Sergio Botero YD Visual Music Courtesy of Epidemic Sound Epidemic Sound http://epidemicsound.com/creator Stellardrone, “Ultra Deep Field”, “Red Giant”, “Billions and Billions”, “Cosmic Sunrise” Lombus, “Hydrogen Sonata”, “Cosmic Soup”

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China has just connected what it believes to be the world’s biggest solar power plant to the grid in northwestern Xinjiang. The plant covers an area of 200,000 acres and is reported to have an output of 6.09 billion kWh annually.

The new plant is in the deserts near the region’s capital Ürümqi. The site came online this Monday (June 3) and is being run by the Chinese state-owned Power Construction Corporation, according to Reuters.

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