A team of scientists at the Research Institute of the McGill University Health Center (The Institute) has made a landmark discovery that sheds light on how the immune system protects the gut during infection. By studying intestinal worms—also known as helminths—the team, led by Professor Irah King, uncovered a previously unknown immune mechanism that preserves intestinal function in the presence of persistent infection.
Their finding, published in the journal Cell, could pave the way for new treatments for helminth infections, which affect over two billion people worldwide at some point in their lives, as well as for other intestinal diseases.
The results could also help revisit older therapeutic strategies that were previously dismissed due to an incomplete understanding of biological processes.