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To create one-time cures for Alzheimer’s disease, researchers are investigating the application of CRISPR-Cas9 gene-editing for novel therapies. Cutting and pasting genes is difficult with current technology, but CRISPR gene editing may help later stages or those individuals with hereditary mutations. Variants in the lipid transport protein apolipoprotein E (APOE4) have been associated with late-onset Alzheimer’s disease, with a three-to twelve-fold increase in risk.

Researchers engineered the Christchurch gene variation into mice bearing human APOE4 using CRISPR. After that, these mice were crossed, resulting in progeny that carried one or two copies of the modified variation.

The group discovered that mice bearing a single copy of the APOE4-Christchurch variation exhibited a partial defense against Alzheimer’s disease. The disease did not exhibit typical symptoms in mice carrying two copies. The work mimics the advantageous effects of the Christchurch mutation to propose possible treatment strategies for Alzheimer’s disease associated with APOE4.

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In the decade since their discovery at Drexel University, the family of two-dimensional materials called MXenes has shown a great deal of promise for applications ranging from water desalination and energy storage to electromagnetic shielding and telecommunications, among others. While researchers have long speculated about the genesis of their versatility, a recent study led by Drexel and the University of California, Los Angeles, has provided the first clear look at the surface chemical structure foundational to MXenes’ capabilities.

Using advanced imaging techniques, known as scanning tunneling microscopy (STM) and scanning tunneling spectroscopy (STS), the team, which also includes researchers from California State University Northridge, and Lawrence Berkeley National Laboratory, mapped the electrochemical surface topography of the titanium carbide MXene — the most-studied and widely used member of the family.

Their findings, published in the 5th anniversary issue of the Cell Press journal Matter (“Atomic-scale investigations of Ti 3 C 2 Tx MXene surfaces”), will help to explain the range of properties exhibited by members of the MXene family and allow researchers to tailor new materials for specific applications.

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The Omega Point cosmo-teleology emerges from the intersection of quantum cosmology, teleology, and complex systems theory. Originally conceptualized by French philosopher Pierre Teilhard de Chardin, the Omega Point envisions the universe evolving towards a state of maximum complexity and consciousness (Teilhard de Chardin, 1955). Such a state represents the ultimate goal and culmination of cosmic evolution, wherein the convergence of mind and matter leads to a unified superintelligence.

The Omega Point theory postulates that the universe’s evolution is directed towards increasing complexity and consciousness, a teleological process with a purposeful end goal (Teilhard de Chardin, 1955). The concept was further refined by physicists and cosmologists, including John David Garcia (Garcia, 1996), Paolo Soleri (Soleri, 2001), Terence McKenna (McKenna, 1991), Frank Tipler (Tipler, 1994), and Andrew Strominger (Strominger, 2016).

A complementary perspective to the Omega Point theory is found in the Holographic Principle, which posits that all information within our universe is encoded on its boundary. Such an idea suggests our three-dimensional reality is a projection from this two-dimensional surface (Bekenstein, 2003). In the holographic universe, everything we perceive is a reflection of data encoded at the cosmic edge, which could imply that our entire universe resides within a black hole of a larger universe (Susskind, 1995). This perspective aligns with the concept of maximum informational density at the Omega Point and highlights the profound interconnectedness of all phenomena, blurring the boundaries between mind, matter, and the cosmos into a singular, computational entity.

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Did you know that the nervous system can help to build and repair bone?

Researchers identify a key brain-derived hormone that repairs bone in both sexes and critically maintains bone density in lactating female mice.

Researchers have found that a brain hormone called CCN3, produced by specific…

A brain-derived hormone, CCN3, is newly identified to have a role as an osteoanabolic factor to build bone in lactating females and in the viability of offspring.

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AUSTIN (KXAN) — Spectrum has restored an outage that impacted users across Texas for about seven hours Tuesday, according to a company spokesperson.

“As of 7:30 p.m. Spectrum services have been restored in parts of Texas that were affected by a third-party infrastructure issue caused by the impact of Hurricane Beryl. We apologize for the inconvenience,” a spokesperson said in the latest update KXAN received via email Tuesday evening.

KXAN has followed up with Spectrum, asking for more details about what exactly this piece of infrastructure is and if it has a backup or reinforcement element.

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Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe’s populations long before the major plague outbreaks of the Middle Ages, new research published in the journal Nature shows.

In the 14th century Europe, the ravaged the population during the so-called “Black Death,” claiming the lives of nearly a third of the population.

But the plague arrived in Scandinavia several thousand years earlier, and despite several theories suggesting otherwise, the plague might have caused an epidemic, according to new research from the University of Copenhagen.

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