Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 10,534

Today, we wanted to draw your attention to a review of aging and the role that the gut microbiome plays in it.

There is an increasing amount of evidence for the contribution of microbial burden in the chronic, age-related background of inflammation known as “inflammaging”. There are a number of proposed sources of inflammaging, including senescent cells, immunosenescence, cell debris, and microbial burden.

We have delved into the topic of the gut microbiome in the past and its possible role as the origin point of inflammaging in a previous article, but we wanted to highlight this publication for people interested in reading further about this rapidly evolving area of aging research [1].

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For centuries humans have sought the ‘elixir of life’ – a mythical potion that supposedly would grant the drinker eternal life.

Now Exeter scientists believe they may have found the secret to a longer, healthier life.

New compounds developed and tested at the University of Exeter have brought the dream a step closer and paved the way for “anti-degeneration” drugs that could not only extend life, but also extend health and may help treat age-related diseases like cancer, dementia and diabetes.

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The compounds — AP39, AP123 and RT01 — have been designed to selectively deliver minute quantities of the gas hydrogen sulphide to the mitochondria in cells and help the old or damaged cells to generate the ‘energy’ needed for survival and to reduce senescence.

In the samples used, the number of senescent cells — older cells that have deteriorated and stopped dividing — was reduced by up to 50 per cent.

The team also identified two splicing factors — a component of cells — that play a key role in when and how endothelial cells become senescent.

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