Lifeboat Foundation: Safeguarding Humanity
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A research team composed of scientists from the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research (A*STAR) and IBM Research has produced a new synthetic molecule that can target and kill five multidrug-resistant bacteria. This synthetic polymer was found to be non-toxic and could enable entirely new classes of therapeutics to address the growing problem of antibiotic-resistant superbugs.

The synthetic molecules are called guanidinium-functionalized polycarbonates and were found to be both biodegradable and non-toxic to human cells. Essentially, the positively-charged synthetic polymer enters a living body and binds specifically to certain bacteria cells by homing in on a microbial membrane’s related negative charge. Once attached to the bacteria, the polymer crosses the cell membrane and triggers the solidification of proteins and DNA in the cell, killing the bacteria.

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When you’re trying to figure out what alien life might look like, it makes sense to be looking in the most extreme environments Earth has available.

One such place where life has been found to thrive is three kilometres (1.86 miles) beneath the ground, the home of one of the strangest lifeforms we know: the bacterium Desulforudis audaxviator.

It lives in complete dark, in groundwater up to 60 degrees Celsius (140 Fahrenheit) — an environment devoid of sunlight, oxygen or organic compounds.

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We know this dip should be found in the radiowave part of the electromagnetic spectrum, at a wavelength of 21cm.

Challenging measurement

This was all predicted by theory. But in practice, the signal is extremely challenging to find. This is because it overlaps with many other signals in this region of the spectrum which are much stronger – such as common frequencies on the FM radio dial and radio waves from other events in our galaxy. The reason the team eventually succeeded was partly down to the experiment’s sensitive receiver and small antenna, which lets you cover a large area of the sky more easily.

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Eye-drops that can repair the corneas and can improve the short and long sightedness have been developed by a team of Ophthalmologists at Shaare Zedek Medical Center and Bar-Ilan University’s Institute of Nanotechnology and Advanced Materials. The solution of nanoparticles called the ‘nanodrops’ was successfully tested on a pig’s cornea. Clinical trials are expected to be carried out later this year. If the clinical trials on humans are successful, it is expected that the need of eyeglasses will be eliminated.

The leader of the research team, Dr. David Smadja, said that the eye-drops can bring a revolution in ophthalmological and optometry treatment of patients who are suffering from myopia, hyperopia and other refractory conditions. The revolutionary breakthrough in the field was revealed by Dr. Smadja at Shaare Zedek’s second biennial research day, which was held at Steinberg Auditorium in Jerusalem. He said that the nano drops can also be used to replace multifocal lenses and allow people to see objects from different distances. Smadja said, “This is a new concept for correcting refractory problems.” However, he didn’t mention the times of applications which will replace the need for the glasses completely.

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Battlefield medics frequently only have a brief window of opportunity to treat an injury before it’s fatal or causes permanent disabilities, and it’s frequently so fleeting that there’s not much they can do. DARPA is exploring an unusual solution to that problem: slow the biological processes to give medics more room to breathe. Its new Biostasis research program aims to bring cell activity to a near halt by using biochemicals that control energetics at the protein level. If animals like tardigrades and wood frogs can stabilize their cells to survive freezing and dehydration, similar techniques might offer more time to medics who want to treat wounds before a victim’s vital systems break down.

DARPA knows this won’t be easy. The trick is to slow down every cellular process at roughly the same rate — you can’t just pause a few while others run at full speed. You’d also have to minimize any damage when the cells return to their normal function.

The Biostasis program is still very young (its first day for answering proposers’ questions is March 20th), and DARPA isn’t expecting too much even from complete projects: it’s initially focusing on “benchtop” proofs of concept and will focus on real-world uses as the program nears its 5-year end. If it has any success, though, the program could prove to be a breakthrough for the medical field as a whole, not just in combat. Paramedics could buy themselves enough time to get a patient to hospital, and doctors could focus less on basic survival and more on full recoveries.

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Last year, scientists took a big step towards creating the next generation of computers.

For the first time ever, they stored light-based information as sound waves on a computer chip — something the researchers compared to capturing lightning as thunder.

While that might sound a little strange, this conversion is critical if we ever want to shift from our current, inefficient electronic computers, to light-based computers that move data at the speed of light.

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