Is anyone interested in a mini-sub?
Elon Musk brought his new lifesaving mini-submarine to Thailand to help save 13 people trapped inside a cave, but rescuers didn’t use it. Here’s what’s next for Musk’s latest invention.
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Scientists can’t take pictures of the Higgs boson. But they can find proof of its existence by watching “E=mc” play out in hundreds of millions of particle collisions per second and detecting how it decays into other particles they do know how to spot. Now, six years after officially discovering the Higgs boson, particle physicists are announcing that they’ve spotted the Higgs in another way.
This announcement isn’t a surprise. It matches the predictions of the Standard Model of particle physics, the rock-solid but probably incomplete blueprint of the Universe on the smallest scales. But the news is certainly important; you might say it closes the first chapter of the Higgs boson’s story, and offers a potential window to explore some of most confounding questions in the Universe.
A new study by the Yale scientists, taking insulin or the most commonly used drug for type 2 diabetes, metformin, failed to either delay or effectively treat the condition in youth.
In the study, dubbed as Restoring Insulin Secretion (RISE) Pediatric Medication Study, scientists explored the impact of two medications for pre-diabetes or diabetes in youth aged 10 to 19. The children and teens either took infusions of insulin for three months, trailed by metformin for a year, or metformin alone. Amid the 15-month contemplate period, the analysts surveyed glucose levels of study members and also the capacity of their beta cells, which store and discharge insulin keeping in mind the end goal to keep up solid glucose.
Scientists discovered that the medications neglected to moderate or stop the progression of type 2 diabetes in either group. The working of the adolescents’ beta cells kept on breaking down in spite of the treatments, which have been appealed to treat write 2 diabetes adequately in adults.
Bucknell has led advanced engineering teams at Chrysler and General Motors for three production high performance engine families. Was Senior Propulsion Engineer for the Raptor full-flow staged combustion methalox rocket at Space Exploration Technologies then Senior Propulsion Scientist for Divergent3D developing vehicle technologies.
In 2017, he described how high temperature (820−1000 degree celsius) nuclear power plants can solve produce synthetic fuel to replace oil.
Experiments to confirm we can see single photons offer new ways to probe our understanding of quantum reality.
- By Anil Ananthaswamy on July 10, 2018
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Soaring global need for cooling by 2050 could see world energy consumption for cooling increase five times as the number of cooling appliances quadruples to 14 billion—according to a new report by the University of Birmingham, UK.
This new report sets out to provide, for the first time, an indication of the scale of the energy implications of ‘Cooling for All’.
Effective cooling is essential to preserve food and medicine. It underpins industry and economic growth, is key to sustainable urbanisation as well as providing a ladder out of rural poverty. With significant areas of the world projected to experience temperature rises that place them beyond those which humans can survive, cooling will increasingly make much of the world bearable—or even safe—to live in. With populations increasing, expanding urbanisation and climate change impacts leading to more frequent heatwaves and temperature rises, the demand for more cooling will increase in the decades ahead.
Researchers isolated several mutations leading to melanoma and reproduced them in the lab using CRISPR.
Two papers authored by researchers at the University of California, San Francisco described the genetic changes that turn harmless moles into malignant melanomas and the experiment they devised to recreate the step-by-step evolution of normal skin cells into cancer cells [1], [2].
Summary ([1])
We elucidated genomic and transcriptomic changes that accompany the evolution of melanoma from pre-malignant lesions by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases. In total, we analyzed 230 histopathologically distinct areas of melanocytic neoplasia from 82 patients. Somatic alterations sequentially induced mitogen-activated protein kinase (MAPK) pathway activation, upregulation of telomerase, modulation of the chromatin landscape, G1/S checkpoint override, ramp-up of MAPK signaling, disruption of the p53 pathway, and activation of the PI3K pathway; no mutations were specifically associated with metastatic progression, as these pathways were perturbed during the evolution of primary melanomas. UV radiation-induced point mutations steadily increased until melanoma invasion, at which point copy-number alterations also became prevalent.
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We wanted to draw your attention to a new publication by James Kirkland and his team. Kirkland is one of the pioneers of senolytics, as he demonstrated that a combination of compounds could remove senescent cells and improve healthspan in mice back in 2015 [1].
The contribution of senescent cells to aging has been the subject of intense research in the last year or two, as researchers have focused on ways to remove these problem cells using therapies known as senolytics.
Do you want to join in the fight to end age-related disease?
Request for Proposals (RFP)
In cooperation with the Forever Healthy Foundation, SENS Research Foundation (SRF) is inviting candidates to submit research proposals for a Fellowship in Rejuvenation Biotechnology that would be undertaken at our Research Center (RC) in Mountain View, California.
SRF pursues the development of therapies to prevent and reverse age-related disease and disability through a “damage-repair” paradigm: developing interventions that maintain and restore the structural and functional integrity of tissues by directly removing, repairing, replacing, or rendering harmless the cellular and molecular damage of aging. Applications are requested that promise progress in regenerative medicine for the prevention and reversal of age-related disease.