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Excess fat triggers immune cells to overeat serotonin in the brain of developing male mice, leading to depression-like behavior. More than half of all women in the United States are overweight or obese when they become pregnant. While being or becoming overweight during pregnancy can have potential health risks for moms, there are also hints that it may tip the scales for their kids to develop psychiatric disorders like autism or depression, which often affects one gender more than the other.

What hasn’t been understood however is how the accumulation of fat tissue in mom might signal through the placenta in a sex-specific way and rearrange the developing offspring’s brain.

To fill this gap, Duke postdoctoral researcher Alexis Ceasrine, Ph.D., and her team in the lab of Duke psychology & neuroscience professor Staci Bilbo, Ph.D., studied pregnant mice on a high-fat diet. In findings appearing November 28 in the journal Nature Metabolism, they found that mom’s high-fat diet triggers immune cells in the developing brains of male but not female mouse pups to overconsume the mood-influencing brain chemical serotonin, leading to depressed-like behavior.

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Mathematics and sex are deeply intertwined. From using mathematics to reveal patterns in our sex lives, to using sex to prime our brain for certain types of problems, to understanding them both in terms of the evolutionary roots of our brain, Dr Clio Cresswell shares her insight into it all.

Dr Clio Cresswell is a Senior Lecturer in Mathematics at The University of Sydney researching the evolution of mathematical thought and the role of mathematics in society. Born in England, she spent part of her childhood on a Greek island, and was then schooled in the south of France where she studied Visual Art. At eighteen she simultaneously discovered the joys of Australia and mathematics, following on to win the University Medal and complete a PhD in mathematics at The University of New South Wales. Communicating mathematics is her field and passion. Clio has appeared on panel shows commenting, debating and interviewing; authored book reviews and opinion pieces; joined breakfast radio teams and current affair programs; always there highlighting the mathematical element to our lives. She is author of Mathematics and Sex.

TEDxSydney is an independently organised event licensed from TED by longtime TEDster, Remo Giuffré (REMO General Store) and organised by his General Thinking network of fellow thinkers and other long time collaborators.

TEDxSydney has become the leading platform and pipeline for the propagation of Australian ideas, creativity, innovation and culture to the rest of the world.

In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)

What will it take for a same-sex couple—two males or two females—to be able to produce a biological child by combining their genomes in the same way that male-female couples do? Just to be clear, we’re not talking about adopting. Nor do we mean one mate fertilizes a donor egg or is fertilized with donated sperm. Those things have long existed. We mean you take two women or two men and make a baby.

And they’ve already done it with two male mice.

The only way we can safeguard against this terrifying future is if nations collectively take action.

You might suppose Hollywood is good at predicting the future. Indeed, Robert Wallace, head of the CIA’s Office of Technical Service and the US equivalent of MI6’s fictional Q, has recounted how Russian spies would watch the latest Bond movie to see what technologies might be coming their way.

Hollywood’s continuing obsession with killer robots might therefore be of significant concern. The newest such movie is Apple TV’s forthcoming sex robot courtroom drama Dolly.

I never thought I’d write the phrase “sex robot courtroom drama”, but there you go.


Mikkelwilliam/iStock.

You might suppose Hollywood is good at predicting the future. Indeed, Robert Wallace, head of the CIA’s Office of Technical Service and the US equivalent of MI6’s fictional Q, has recounted how Russian spies would watch the latest Bond movie to see what technologies might be coming their way.

Hollywood’s continuing obsession with killer robots might therefore be of significant concern. The newest such movie is Apple TV’s forthcoming sex robot courtroom drama Dolly.

I never thought I’d write the phrase “sex robot courtroom drama”, but there you go. Based on a 2011 short story by Elizabeth Bear, the plot concerns a billionaire killed by a sex robot that then asks for a lawyer to defend its murderous actions.

Summary: Oxytocin, a hormone connected with bonding and love, could help to heal damage following a heart attack. Researchers found oxytocin stimulates stem cells from the heart’s outer layer and migrates into the middle layer where it develops into muscle cells that generate heart contractions. This could be used to promote the regeneration of heart cells following a heart attack.

Source: Frontiers.

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.

Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another unsuspected function: It stimulates derived from the heart’s outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, that generate heart contractions. This discovery could one day be used to promote the regeneration of the human heart after a . The results are published in Frontiers in Cell and Developmental Biology.

“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” said Dr. Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study’s senior author.

Personalized Bio-Engineered Human Hearts For All — Dr. Doris A. Taylor, Ph.D., CEO, Organamet Bio Inc.


Dr. Doris A. Taylor, Ph.D. is Chief Executive Officer of Organamet Bio Inc. (https://organametbio.com/) an early phase start-up committed to saving lives and reducing the cost of healthcare for those with heart disease. Organamet has a goal is to make personalized bio-engineered human hearts, available to all who need them, within 5 years, increasing availability and access to hearts, decreasing or eliminating need for immunosuppression, reducing total lifetime transplant costs, and improving quality of life.

Dr. Taylor was previously the Director, Regenerative Medicine Research and Director, Center for Cell and Organ Biotechnology, at the Texas Heart Institute in Houston, Texas, where she worked on the integration of regenerative medicine and tissue engineering.

Dr. Taylor has a Ph.D. in Pharmacology from UT Southwestern Medical Center, Dallas, Texas. She did her post-doctoral studies at Albert Einstein College of Medicine in the Bronx, New York, where she first worked with tissue engineering, growing heart muscle cells in the laboratory.

Dr. Taylor was on the faculty of Duke University from 1991 to 2007, and then moved to University of Minnesota, where in 2008 her team published a landmark paper in Nature Medicine where they created new beating rat hearts using a combination of tissue engineering processes, first stripping the dead dying cells away from an existing heart (in a process called “de-cellularization”) leaving behind the hearts extracellular matrix and then re-seeding the matrix by injecting new young rat stem cells.