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Efficacy of Pyridostigmine in Myasthenia GravisA Randomized, Double-Blind, Placebo-Controlled Crossover Trial

Class I evidence that, in adults with AChRAb+ ocular or generalized myasthenia gravis (MG) on stable standard-of-care therapy and currently using pyridostigmine, pyridostigmine improves MG symptoms compared with placebo.


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Genetic Landscape and Diagnostic Outcomes of UK Patients With Congenital Myopathies and Muscular Dystrophies Over a 10-Year Period

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Case Fatality of Subarachnoid Hemorrhage by Aneurysm LocationA Population-Based Study From Finland and New Zealand

Case fatality of subarachnoid hemorrhage by aneurysm location a population-based study from finland and new zealand.


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Middle-Aged Carotid Plaque and Cognitive Functions in Later LifeA Population-Based Study

In this large cohort study, carotid plaque status at baseline was independently associated with in cognitive function decline, especially in nonverbal memory and executive functioning over 8-year follow-up period in the general population.


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Novel ADPRS Missense Variant (p.Leu162Pro) Causes Stress-Induced Childhood-Onset Neurodegeneration With Ataxia and Seizures

Novel ADPRS Missense Variant (p. Leu162Pro) Causes Stress-Induced Childhood-Onset Neurodegeneration With Ataxia and Seizures.


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Google now offers up to $1.5 million for some Android exploits

Google overhauls its Android and Chrome vulnerability rewards programs, offering bounties of up to $1.5 million for the most difficult exploits while scaling back payouts for flaws that artificial intelligence (AI) has made easier to find.

The top reward of $1.5 million is reserved for zero-click Pixel Titan M2 security chip full-chain exploits with persistence, the most technically demanding attack scenario in the program, while the same exploits, but without persistence, are also eligible for up to $750,000.

On the Google Chrome side, full-chain browser process exploits on up-to-date operating systems and hardware now come with rewards of up to $250,000, plus an additional $250,128 bonus for successfully exploiting MiraclePtr-protected memory allocations.

This best-selling book is freaking out national security advisors

Our second video just won a Webby’s People’s Voice Award! → http://bit.ly/3OVCA1i.

Way more thoughts, our curated newsletter, and free books (until we run out) → https://80000hours.org/iabied/

If we build something vastly smarter than us, with goals we don’t share and without knowing how to control it, we lose. That’s the core claim in the book, and I don’t think it’s all that controversial. The real question is whether that’s where we’re headed.

If this matters to you, subscribe to AI in Context. We’re working through it too.

Correction: at 14:18 I say \.

Stacked intelligent surfaces could boost wireless reliability and security for 6G

Wireless communication is about to get stronger, clearer, and more secure, thanks to a new idea from UBC Okanagan researchers. Dr. Anas Chaaban and his team in the School of Engineering are exploring a method to improve the way stacked intelligent surfaces (SIS) can process electromagnetic waves more efficiently.

SIS is an emerging alternative to conventional wireless hardware, Dr. Chaaban says, as layers of specially engineered materials are used to directly manipulate electromagnetic waves.

“Electromagnetic waves travel through special surfaces that consist of several elements. These elements mimic neurons in a computerized neural network,” Dr. Chaaban says. “As the waves move through the surface, each element changes them slightly. When the waves come out, they are captured by antennas that send the signals to digital processors for further analysis.”

Microsoft fixes Remote Desktop warnings displaying incorrectly

Microsoft has fixed a known issue causing newly introduced Windows security warnings to display incorrectly when opening Remote Desktop (.rdp) files.

This known issue affects all supported Windows versions, including Windows 11 (KB5083768 & KB5083769), Windows 10 (KB5082200), and Windows Server (KB5082063), on devices with multiple monitors and different display scaling settings.

Microsoft addressed the bug in the optional KB5083631 preview cumulative update for Windows 11, released on Thursday, along with 34 other changes.

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