Lifeboat Foundation

One prevailing hypothesis is that physical fitness mitigates structural brain changes that contribute to cognitive decline. Recent evidence points to a potential role involving myelin —the insulating sheath surrounding neurons that is crucial for efficient neural signaling and overall cognitive health. Myelination facilitates rapid signal transmission and supports neural network integrity.

The degeneration of myelin in the brain is increasingly recognized as a critical factor contributing to disruptions in neural communication, which may play a significant role in the cognitive decline observed in Alzheimer’s disease and other neurodegenerative disorders. Emerging research suggests that myelin breakdown may even precede the formation of amyloid-beta plaques and neurofibrillary tangles—the hallmark pathological features of Alzheimer’s disease. Advanced imaging studies have detected early myelin degeneration in individuals who later develop Alzheimer’s, indicating that myelin damage could be an initial event in the disease’s progression.

Age-related deterioration of myelin is closely associated with cognitive decline. Reduced white matter integrity—often resulting from myelin damage—is correlated with declines in memory, executive function, and processing speed in older adults. As myelin degradation leads to the slowing of cognitive processes and disrupts the synchronization of neural networks, preserving myelin integrity is essential for sustaining cognitive health across the lifespan.

27K likes, — logicure on October 3, 2024: Ballie is a soccer ball-sized, yellow, spherical AI-powered robot created by Samsung Electronics that can navigate homes and perform tasks such as controlling smart home devices, projecting images, and communicating with users.

Ballie was first introduced at CES 2020 and an upgraded version was unveiled at CES 2024.

Follow @logicure for more amazing content.

“If you constantly use an AI to find the music, career or political candidate you like, you might eventually forget how to do this yourself.” Ethicist Muriel Leuenberger considers the personal impact of relying on AI.

King Frederik X of Denmark practically called Huang a king with a leather jacket on.

Media Advisory: Cybersecurity & Emerging Tech Expert and Georgetown professor Chuck Brooks Media Availability.

Automatically interpreting millions of features in large language models.

Gonçalo Paulo, Alex Mallen, Caden Juang, Nora Belrose Eleuther AI 2024 https://arxiv.org/abs/2410.13928 https://github.com/EleutherAI/sae-auto-interp

We’re on a journey to advance and democratize artificial intelligence through open source and open science.

By Chuck Brooks, Skytop Contributor / October 25, 2024

Chuck Brooks serves as President and Consultant of Brooks Consulting International. Chuck also serves as an Adjunct Professor at Georgetown University in the Cyber Risk Management Program, where he teaches graduate courses on risk management, homeland security, and cybersecurity.

Chuck has received numerous global accolades for his work and promotion of cybersecurity. Recently, he was named the top cybersecurity expert to follow on social media, and also as one top cybersecurity leaders for 2024. He has also been named “Cybersecurity Person of the Year” by Cyber Express, Cybersecurity Marketer of the Year, and a “Top 5 Tech Person to Follow” by LinkedIn” where he has 120,000 followers on his profile.

As a thought leader, blogger, and event speaker, he has briefed the G20 on energy cybersecurity, The US Embassy to the Holy See, and the Vatican on global cybersecurity cooperation. He has served on two National Academy of Science Advisory groups, including one on digitalizing the USAF, and another on securing BioTech. He has also addressed USTRANSCOM on cybersecurity and serves on an industry/government Working group for DHS CISA focused on security space systems.

Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.

“What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for,” said Ryan Tewhey, PhD, an associate professor at The Jackson Laboratory and co-senior author of the work. “This creates the opportunity for us to turn the expression of a gene up or down in just one tissue without affecting the rest of the body.”

In recent years, genetic editing technologies and other gene therapy approaches have given scientists the ability to alter the genes inside living cells. However, affecting genes only in selected cell types or tissues, rather than across an entire organism, has been difficult. That is in part because of the ongoing challenge of understanding the DNA switches, called cis-regulatory elements (CREs), that control the expression and repression of genes.

In conclusion, don’t accept what the AI tells you as absolute truth. Don’t make critical decisions based on its answers. And remember that you sometimes have to negotiate with the AI before it’s willing to give you helpful answers.

This test is yet another case where I’ve been able to turn to the AI and find an answer for a very me-specific question without coding in minutes.

If you have a question that requires a lot of text or numerical analysis, consider running it by ChatGPT or one of the other AIs. You might get a useful answer in minutes.