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Molecular and phenotypic biomarkers of aging

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging are valuable tools to measure physiological age, assess the extent of ‘healthy aging’, and potentially predict health span and life span for an individual. Given the complex nature of the aging process, the biomarkers of aging are multilayered and multifaceted. Here, we review the phenotypic and molecular biomarkers of aging. Identifying and using biomarkers of aging to improve human health, prevent age-associated diseases, and extend healthy life span are now facilitated by the fast-growing capacity of multilevel cross-sectional and longitudinal data acquisition, storage, and analysis, particularly for data related to general human populations. Combined with artificial intelligence and machine learning techniques, reliable panels of biomarkers of aging will have tremendous potential to improve human health in aging societies.

Keywords: physiological age, phenotypic, molecular, age-associated diseases, aging process.

Aging is the time-dependent physiological functional decline that affects most living organisms, which is underpinned by alterations within molecular pathways, and is also the most profound risk factor for many non-communicable diseases. To identify biomarkers of aging would, on one hand, facilitate differentiation of people who are of the same chronological age yet have variant aging rates. Quantitative biomarkers of aging could also define a panel of measurements for ‘healthy aging’ and, even further, predict life span. On the other hand, biomarkers of aging could also assist researchers to narrow their research scope to a specific biological facet in their attempts to explain the biological process behind aging or aging-related diseases. Here, we review the phenotypic and molecular biomarkers of aging. Phenotypic biomarkers can be non-invasive, panoramic, and easy to obtain, whereas molecular biomarkers can reflect some of the molecular mechanisms underlying age status.

Schrodinger’s superconductor naturally stable in two states at once

Quantum computers have the potential to someday far outperform our traditional machines, thanks to their ability to store data on “qubits” that can exist in two states at once. That sounds good in theory, but in practice it’s hard to make materials that can do that and stay stable for long periods of time. Now, researchers from Johns Hopkins University have found a superconducting material that naturally stays in two states at once, which could be an important step towards quantum computers.

Our current computers are built on the binary system. That means they store and process information as binary “bits” – a series of ones and zeroes. This system has worked well for us for the better part of a century, but the general rate of computing progress has started to slow down in recent years.

Quantum computers could turn that trend on its head. The key is the use of qubits, which can store data as either a one, a zero or both at the same time – much like Schrödinger’s famous thought experiment with the cat that’s both alive and dead at the same time. Using that extra power, quantum computers would be able to outperform traditional ones at tasks involving huge amounts of data, such as AI, weather forecasting, and drug development.

Why deep-learning AIs are so easy to fool

These are just some examples of how easy it is to break the leading pattern-recognition technology in AI, known as deep neural networks (DNNs). These have proved incredibly successful at correctly classifying all kinds of input, including images, speech and data on consumer preferences. They are part of daily life, running everything from automated telephone systems to user recommendations on the streaming service Netflix. Yet making alterations to inputs — in the form of tiny changes that are typically imperceptible to humans — can flummox the best neural networks around.


Artificial-intelligence researchers are trying to fix the flaws of neural networks.

These clothes use outlandish designs to trick facial recognition software into thinking you’re not a human

Smile! You’re on camera — or you were at some point in the past few years — and now your face is public domain.

Facial recognition technology is everywhere, and only becoming more pervasive. It’s marketed as a security feature by companies like Apple and Google to prevent strangers from unlocking your iPhone or front door.

It’s also used by government agencies like police departments. More than half of adult Americans’ faces are logged in police databases, according to a study by Georgetown researchers. Facial recognition technology is used by governments across the globe to identify and track dissidents, and has been deployed by police against Hong Kong protesters.

These new soft actuators could make soft robots less bulky

Engineers at the University of California San Diego have developed a way to build soft robots that are compact, portable and multifunctional. The advance was made possible by creating soft, tubular actuators whose movements are electrically controlled, making them easy to integrate with small electronic components.

As a proof of concept, engineers used these new actuators to build a soft, battery-powered robot that can walk untethered on flat surfaces and move objects. They also built a soft gripper that can grasp and pick up small objects.

The team, led by UC San Diego mechanical and aerospace engineering professor Shengqiang Cai, published the work Oct. 11 in Science Advances.

Watch an AI robot program itself to, er, pick things up and push them around

Vid Robots normally need to be programmed in order to get them to perform a particular task, but they can be coaxed into writing the instructions themselves with the help of machine learning, according to research published in Science.

Engineers at Vicarious AI, a robotics startup based in California, USA, have built what they call a “visual cognitive computer” (VCC), a software platform connected to a camera system and a robot gripper. Given a set of visual clues, the VCC writes a short program of instructions to be followed by the robot so it knows how to move its gripper to do simple tasks.

“Humans are good at inferring the concepts conveyed in a pair of images and then applying them in a completely different setting,” the paper states.

Ghana launches second drone delivery base at Mampong

President Nana Addo Dankwa Akufo-Addo on Thursday opened Ghana’s newest medical drone delivery base at Asante Mampong as part of his duty tour of the Ashanti region this week.

This marks the second of what will be four medical drone delivery bases that have been commissioned to help expand access to critical and life-saving medicines for people across Ghana.

Zipline, a California-based robotics company, operates the medical drone delivery service with support from Gavi, the Vaccine Alliance, the Bill & Melinda Gates Foundation, the UPS Foundation and other partners.

Cut Your Own Vinyl Records With This $1,100 Machine

3D Printing was one example of how technological advancement made manufacturing accessible to all. Will robots take all the jobs? I doubt it, but technological advancement will make many things inaccessible, accessible to many more than before, by lowering the cost of production. This is but one example.

Better clear out several shelves of storage space, vinylheads, because your record collection is about to expand into infinity. Soon, you’ll be able to get absolutely anything on vinyl. Even better—you’ll be able to make it.


The Phonocut is an at-home vinyl lathe, allowing anyone with a digital audio file and a dream to make a 10-inch record.

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