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Design of multimodal antibiotics against intracellular infections using deep learning

The rise of antimicrobial resistance has rendered many treatments ineffective, posing serious public health challenges. Intracellular infections are particularly difficult to treat since conventional antibiotics fail to neutralize pathogens hidden within human cells. However, designing molecules that penetrate human cells while retaining antimicrobial activity has historically been a major challenge. Here, we introduce APEXDUO, a multimodal artificial intelligence (AI) model for generating peptides with both cell-penetrating and antimicrobial properties. From a library of 50 million AI-generated compounds, we selected and characterized several candidates. Our lead, Turingcin, penetrated mammalian cells and eradicated intracellular Staphylococcus aureus. In mouse models of skin abscess and peritonitis, Turingcin reduced bacterial loads by up to two orders of magnitude. In sum, APEXDUO generated multimodal antibiotics, opening new avenues for molecular design.

CFN provides consulting services to Invaio Sciences and is a member of the Scientific Advisory Boards of Nowture S.L., Peptidus, European Biotech Venture Builder and Phare Bio. CFN is also a member of the Advisory Board for the Peptide Drug Hunting Consortium (PDHC). The de la Fuente Lab has received research funding or in-kind donations from United Therapeutics, Strata Manufacturing PJSC, and Procter & Gamble, none of which were used in support of this work. An invention disclosure associated with this work has been filed. All other authors declare no competing interests.

ByteDance’s OmniHuman-1 may be the most realistic deepfake algorithm yet

We may be well past the uncanny valley point right now. OmniHuman-1’s fake videos look startlingly lifelike, and the model’s deepfake outputs are perhaps the most realistic to date. Just take a look at this TED Talk that never actually took place.

The system only needs a single photo and an audio clip to generate these videos from scratch. You can also adjust elements such as aspect ratio and body framing. The AI can even modify existing video footage, editing things like body movements and gestures in creepily realistic ways.

How to keep AI from killing us all

If left unchecked, powerful AI systems may pose an existential threat to the future of humanity, say UC Berkeley Professor Stuart Russell and postdoctoral scholar Michael Cohen.

Society is already grappling with myriad problems created by the rapid proliferation of AI, including disinformation, polarization and algorithmic bias. Meanwhile, tech companies are racing to build ever more powerful AI systems, while research into AI safety lags far behind.

Without giving powerful AI systems clearly defined objectives, or creating robust mechanisms to keep them in check, AI may one day evade human control. And if the objectives of these AIs are at odds with those of humans, say Russell and Cohen, it could spell the end of humanity.

Who will win the AI race: $1 trillion dollar questions | Marc Andreessen and Lex Fridman

Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=OHWnPOKh_S0
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Marc Andreessen is an entrepreneur, investor, co-creator of Mosaic, co-founder of Netscape, and co-founder of the venture capital firm Andreessen Horowitz.

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AI and scientists unite to decipher old scrolls charred by the Vesuvius volcano

Scientists hope a mix of artificial intelligence and human expertise will help decipher ancient scrolls carbonized by a volcanic eruption 2,000 years ago.

Hundreds of papyrus scrolls were found in the 1750s amid the remains of a lavish villa at the Roman town of Herculaneum, which along with neighboring Pompeii was destroyed when Mt. Vesuvius erupted in A.D. 79.

The library of what’s called the Villa of the Papyri has the potential to add immeasurably to knowledge of ancient thought if the scrolls, which have been rolled up into the size of a candy bar, could be read.