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Genetic correlations between pain phenotypes and depression and neuroticism

Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.

A Breakthrough in Spinal Cord Injury Treatment with Dr. Wise Young

Ira Pastor, ideaXme exponential health ambassador and founder of Bioquark, interviews Dr Wise Young M.D., Ph.D., the Richard H. Shindell Chair in Neuroscience, Distinguished Professor of Cell Biology & Neuroscience and the Founding Director of the W. M. Keck Center for Collaborative Neuroscience at Rutgers University.

If you enjoy this interview please donate to ideaXme here https://radioideaxme.com/contact/.

Spinal Cord Injury

A spinal cord injury (SCI) is defined as any damage to the spinal cord that causes temporary or permanent changes in its function.

Depending on the location and severity of the damage, the symptoms vary, from numbness to paralysis to incontinence. Long term outcomes also vary widely, from full recovery to permanent quadriplegia or paraplegia. Complications can include muscle atrophy, pressure sores, infections, and breathing problems.

Direct medical expenses for spinal cord injuries can run into millions of dollars (not including lost wages and earning potential) and can include: spinal surgery, trauma care (use of a ventilator) rehabilitation (including physical and occupational therapy, speech therapy, and mental health counseling), long-term care, including the costs of in-home aides, medical equipment such as wheelchairs, and medication such as painkillers and antibiotics.

The Ouroboros Code: Bridging Advanced Science and Transcendental Metaphysics

By contemplating the full spectrum of scenarios of the coming technological singularity many can place their bets in favor of the Cybernetic Singularity which is a sure path to digital immortality and godhood as opposed to the AI Singularity when Homo sapiens is retired as a senescent parent. This meta-system transition from the networked Global Brain to the Gaian Mind is all about evolution of our own individual minds, it’s all about our own Self-Transcendence. https://www.ecstadelic.net/top-stories/the-ouroboros-code-br…etaphysics #OuroborosCode


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