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Category: neuroscience – Page 981

Like a team in a science fiction movie, the six-lab squad funded by a 2017 MEDx Biomedical research grant is striking in its combination of diverse skills and duties.

The project is led by Kafui Dzirasa, MD’09, Ph.D.’07, HS’10-’16, associate professor of psychiatry and behavioral sciences and assistant professor in neurobiology and neurosurgery; and Nenad Bursac, Ph.D., professor of biomedical engineering and associate professor in medicine. Their team includes: Marc Caron, Ph.D., James B. Duke Professor of Cell Biology, professor in neurobiology and medicine; Fan Wang, Ph.D., professor of neurobiology; Christopher Kontos, MD, HS’93-’97, professor of medicine and associate professor of pharmacology and cancer biology—all at Duke University School of Medicine—and Jennie Leach, Ph.D., associate professor of chemical, biochemical, and environmental engineering at the University of Maryland Baltimore County, along with a cadre of committed graduate students, postdocs, and technicians.

Dzirasa’s background in engineering informs his approach to the study of neuropsychiatric illness and disease. In the summer of 2016, he and members of his lab were discussing the challenge of precisely monitoring .

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The strange case of a young boy who had a large section of his brain removed shows just how good the human brain is at repairing itself — or at least making the most of a tough situation. Beyond being just a lump of tissue that named itself, the brain is also a kind of wonderful, wet computer that’s capable of rewiring itself in response to new experiences like taking drugs, forming new memories, and making friends. In extreme cases, like that of a 6-year-old boy who had about one-sixth of his brain removed, the brain can even adapt to getting cut apart.

Doctors documented the boy’s case in a paper published July 31 in the journal Cell Reports. They report that despite the boy having a significant portion of his brain removed, including the portion associated with visual processing, the boy has developed into a healthy 10-year-old. And while he still can’t see in the left side of his field of vision, his brain has reconfigured some of the lost connections so that he is able to recognize people’s faces. All in all, the doctors see it as a successful procedure, as well as evidence of the brain’s plasticity — its ability to adapt — when it comes to higher-order functions.

“He is essentially blind to information on the left side of the world. Anything to the left of his nose is not transmitted to his brain, because the occipital lobe in his right hemisphere is missing and cannot receive this information,” Marlene Behrmann, Ph.D., a professor of psychology at Carnegie Mellon University and the corresponding author on the paper, tells New Scientist.

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Hopefully in the future, when somebody tells you they will be making an appointment with a surgeon for an augment, they will come back smarter. The world will be a better place for it.

Reprinted with permission from the author.

Eric C. Leuthardt, M.D., is a neurosurgeon who is currently a professor with the Department of Neurological Surgery and the Department of Biomedical Engineering at Washington University in St. Louis. He is Director of the Center for Innovation in Neuroscience and Technology and the Brain Laser Center. His work has yielded him numerous accolades as a scientist, a neurosurgeon, and an inventor. He was named one of the Top Young Innovators by MIT’s magazine Technology Review. The magazine names individuals under the age of 35 each year whose work in technology has global impact. In addition to numerous peer reviewed publications, Leuthardt has numerous patents on file with the U.S. Patent and Trademark Office for medical devices and brain computer interface technologies.

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The year is 2050 and researchers have developed an advanced method of replacing 99% of your brain’s functions for digital software/hardware. The process is slow to ensure individuals aren’t simply making copies of themselves. But in return, “digital immortality” has been achieved.

In a future of mind-uploaded “immortals,” will we achieve unlimited freedom or will we simply become slaves to a private entity which owns the data that makes up our own digital minds?

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Published in Scientific Reports, this study is the first to provide evidence of new neuron formation—and the presence of stem cells—in the leopard gecko brain.

University of Guelph researchers have discovered the type of stem cell allowing geckos to create new brain cells, providing evidence that the lizards may also be able to regenerate parts of the brain after injury.

This finding could help in replacing human brain cells lost or damaged due to injury, aging or disease.

“The brain is a complex organ and there are so few good treatments for brain injury, so this is a very exciting area of research,” said Prof. Matthew Vickaryous in the Department of Biomedical Sciences at the Ontario Veterinary College (OVC).

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A new way of administering drugs for wet age-related macular degeneration might be close.

Two studies by researchers at the University of Birmingham have shown that delivering drugs against the wet form of age-related macular degeneration (AMD) in the form of eyedrops might soon be possible in humans [1, 2].

What is age-related macular degeneration?

AMD is a pathology of the retina, which is a light-sensitive tissue located in the back of the eye and is similar to the film in a non-digital camera. Two-dimensional images are created on the retina and are subsequently transferred to the brain in the form of electrical neural impulses. Near the center of the retina is the macula, an oval-shaped region responsible for central, high-resolution, color vision. In AMD, the macula is damaged, impairing or preventing this kind of vision. AMD is progressive, but it cannot lead to total blindness, as it doesn’t affect peripheral vision. It comes in two forms, wet and dry, with the latter being overwhelmingly more common and, unfortunately, presently incurable. As the name suggests, the highest risk factor for AMD is age; the disease is usually observed only in patients over 50.

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Dreaming is one of the strangest things that happens to us, and for as long as we have been recording history, we have been puzzling over why our minds are so active while we sleep.

Finally, new research claims to have evidence as to what dreaming is all about — and it will probably surprise no one.

According to a team from The Swansea University Sleep Lab in the UK, dreaming really does help us process the memories and emotions we experience during our waking lives.

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