Lifeboat Foundation: Safeguarding Humanity
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Category: neuroscience – Page 974

He is the first patient to receive an experimental gene therapy as part of a clinical trial. Earlier this week, Sangamo Therapeutics injected Madeux with viruses containing a package of gene-editing material, according to the AP. The hope is that these viruses will enter Madeux’s cells, specifically liver cells, inject the missing gene at the right place in his DNA. Only about 1% of the liver’s cells need to be fixed, and give his liver the ability to produce the enzyme he has been missing all his life.

Brian Madeux’s life hasn’t been easy. So far, he’s had 26 operations to fix problems in everything from hernias to eyes. He has a rare disease called Hunter syndrome, which is caused by the lack of a gene that’s used to produce an enzyme that breaks down certain carbohydrates. As a result, the carbohydrates build up in his body’s cells causing all sorts of problems.

There is no cure. One way to deal with some of the symptoms is to receive regular doses of the missing enzyme, which may cost him in the US between $100,000 and $400,000 per year. Even then, the enzyme won’t reverse the damage made already and it won’t stop further deterioration that happens in the brain.

But Madeux’s life might be about to change. He is the first patient to receive an experimental gene therapy as part of a clinical trial. Earlier this week, Sangamo Therapeutics injected Madeux with viruses containing a package of gene-editing material, according to the AP. The hope is that these viruses will enter Madeux’s cells, specifically liver cells, inject the missing gene at the right place in his DNA. Only about 1% of the liver’s cells need to be fixed, and give his liver the ability to produce the enzyme he has been missing all his life.

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With everyone from Elon Musk to MIT to the US Department of Defense researching brain implants, it seems only a matter of time before such devices are ready to help humans extend their natural capabilities.

Now, a professor from the University of Southern California (USC) has demonstrated the use of a brain implant to improve the human memory, and the device could have major implications for the treatment of one of the US’s deadliest diseases.

Dong Song is a research associate professor of biomedical engineering at USC, and he recently presented his findings on a “memory prosthesis” during a meeting of the Society for Neuroscience in Washington D.C. According to a New Scientist report, the device is the first to effectively improve the human memory.

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The SYFY25: Origin Stories Podcast, hosted by Adam Savage (editor-in-chief, tested.com and former co-host of Mythbusters), is a nostalgic celebration of all things science fiction. In this podcast series Adam sits down with creators, thought-leaders, and celebrity fans to discuss the moments, people, and milestones that have changed the genre universe forever. From revealing personal anecdotes to deep philosophical discussions.

Transhumanist philosopher Natasha Vita-More chats with Adam and explains what transhumanism means for us regular humans, how it will impact the evolution of humanity, and close we are to uploading our brains into databases, ensuring our immortality.

Listen on iTunes.

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Tiny human brains connected to the minds of rats have sparked a major ethical debate among researchers.

Two papers being presented at a renowned US neuroscience conference this week claim to have hooked human brain tissue to the minds of rats and mice.

Ethicists have questioned whether the move could one day give the animals a consciousness, meaning they will be entitled to ‘respect’ in future.

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Transistors, those tiny electrical switches that process signals and data, are the brain power behind every electronic device – from laptops and smartphones to your digital thermostat. As they continue to shrink in size, computers have become smaller, more powerful, and more pervasive. However, as we look to build squishy, human-friendly machines that have the look and feel of soft natural organisms, we need to look beyond the rigid materials used to create electrical switches and circuits.

Mechanical engineers Carmel Majidi and James Wissman of the Soft Machines Lab at Carnegie Mellon University have been looking at new ways to create electronics that are not just digitally functional but also soft and deformable. Rather than making from rigid metals like copper or silver, they use a special metal alloy that is liquid at room temperature. This alloy, made by mixing indium and gallium, is a non-toxic alternative to mercury and can be infused in rubber to make circuits that are as soft and elastic as natural skin.

Teaming up with Michael Dickey at North Carolina State University, they recently discovered that electronics are not only useful for stretchable circuit wiring but can also be used to make . These fluidic transistors work by opening and closing the connection between two liquid metal droplets. When a voltage drop is applied in one direction, the droplets move towards each other and coalesce to form a metallic bridge for conducting electricity. When voltage is applied in a different direction, the droplets spontaneously break apart and turn the switch to open. By quickly alternating between an open and closed and open switch state with only a small amount of voltage, the researchers were able to mimic the properties of a conventional transistor.

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“Room temperature quantum sensors can be mounted directly on the scalp of any subject. This will give us a projected four-fold increase in sensitivity for adults, but the sensitivity could potentially be up to a 15 or 20 fold increase for children or babies.”

A £1.6 million collaborative project between scientists at the University of Nottingham and University College London (UCL) is looking to improve the way we map the human brain. Focusing on the development of magnetoencephalography (MEG), researchers have 3D printed a prototype helmet that may yield quadruple the sensitivity of current MEG devices.

Reading at room temperature

In MEG, sensors capable of detecting the most sensitive magnetic fields emitted by the brain are added close to the scalp. Traditionally, these sensors would require cryogenic cooling (down to – 269 degrees) for operation. Nottingham and UCL’s MEG device uses the newly invented SERF sensors meaning that they can operate at room temperature and be placed directly on the skin.

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In many ways, stem cells are the divas of the biological world. On the one hand, these natural shapeshifters can transform themselves into virtually any type of cell in the body. In that regard, they hold the promise of being able to cure ills ranging from spinal cord injuries to cancers.

On the other hand, said associate professor of materials science and engineering Sarah Heilshorn, , like divas, are also mercurial and difficult to work with.

“We just don’t know how to efficiently and effectively grow massive numbers of stem and keep them in their regenerative state,” Heilshorn said. “This has prevented us from making more progress in creating therapies.”

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A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes — a specific virus and two specific types of bacteria — are major causes of Alzheimer’s Disease. Their paper, which has been published online in the highly regarded peer-reviewed journal, Journal of Alzheimer’s Disease, stresses the urgent need for further research — and more importantly, for clinical trials of anti-microbial and related agents to treat the disease.

This major call for action is based on substantial published evidence into Alzheimer’s. The team’s landmark editorial summarises the abundant data implicating these microbes, but until now this work has been largely ignored or dismissed as controversial — despite the absence of evidence to the contrary. Therefore, proposals for the funding of clinical trials have been refused, despite the fact that over 400 unsuccessful clinical trials for Alzheimer’s based on other concepts were carried out over a recent 10-year period.

Opposition to the microbial concepts resembles the fierce resistance to studies some years ago which showed that viruses cause certain types of cancer, and that a bacterium causes stomach ulcers. Those concepts were ultimately proved valid, leading to successful clinical trials and the subsequent development of appropriate treatments.

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