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Brain Computer Interfaces Developed by DARPA, US Department of Defense

If you are interested in brain computer interfaces (BCI), then you need to listen to this very exciting podcast!

I have only been aware of this DARPA NNN (Next-generation Non-surgical Neurotechnology) program since mid-March, and it is my number one topic of interest. I am interested in it because I have a plan for mind uploading to extend my life indefinitely — otherwise known as superlongevity in our group — but I have no interest in allowing anyone to drill holes in my head! DARPA is looking at ways for non-invasive methods of connecting the thoughts in our brains to computers. Over time, this could be a method to capture the thoughts and memories and emotions within my mind and transfer them into a computer substrate. And, to be clear, this mind upload will, in fact, be me.

Naturally, DARPA is not developing this so that I can upload my mind. This is part of their wounded warrior project, where they are trying to rehabilitate soldiers who have had the misfortune to have lost a limb. In addition to the non-invasive neural technology, they are working on haptics to provide a feedback loop for the sense of touch and temperature. They are also working on what they describe as third wave AI to support this technology.

The interview is with Dr Al Emondi, who has had a fascinating career in technology. He is the DARPA program manager in the Biological Technologies department.

I will always admire DARPA for its world-changing technology innovations!


Drug stimulation of neural stem cell repair leads to promising impact on treatment of childhood brain injury

Through a cross-species study of metformin, a common drug used to treat Type 2 diabetes, a team of researchers and clinicians from the Donnelly Center and The Hospital for Sick Children (SickKids) has shown that it could one day be possible to repair brain injury using resident cells in the brain.

“No one’s actually shown before that you can take a drug where there’s a known mechanism on endogenous stem cells and demonstrate that it’s even possible to induce and positive recovery,” says Donald Mabbott, Program Head and Senior Scientist in the Neurosciences & Mental Health program at SickKids, and co-author of a study published in Nature Medicine on July 27.

Mabbott says metformin is a potential game-changer in terms of how childhood brain injury is treated.

Further Evidence World Trade Center Responders Are at Risk for Dementia

Summary: First responders at the World Trade Center have reduced cortical gray matter thickness, which was consistent with neurodegenerative conditions and evidence their brain age is, on average, ten years older than those of similar ages in the general population.

Source: Stony Brook University

Two studies led by Stony Brook University researchers to be presented virtually at the Alzheimer’s Association International Conference on July 28, 2020, indicate that World Trade Center (WTC) first responders are at risk for developing dementia. The studies included individuals with signs of cognitive impairment (CI) who show neuroradiological abnormalities and changes in their blood similar to that seen in Alzheimer’s disease patients and those with related dementias.

MIT Dream Research Interacts Directly With an Individual’s Dreaming Brain and Manipulates the Content

Device not only helps record dream reports, but also guides dreams toward particular themes.

The study of dreams has entered the modern era in exciting ways, and researchers from MIT and other institutions have created a community dedicated to advancing the field, lending it legitimacy and expanding further research opportunities.

In a new paper, researchers from the Media Lab’s Fluid Interfaces group introduce a novel method called “Targeted Dream Incubation” (TDI). This protocol, implemented through an app in conjunction with a wearable sleep-tracking sensor device, not only helps record dream reports, but also guides dreams toward particular themes by repeating targeted information at sleep onset, thereby enabling incorporation of this information into dream content. The TDI method and accompanying technology serve as tools for controlled experimentation in dream study, widening avenues for research into how dreams impact emotion, creativity, memory, and beyond.

Breakthrough in autism spectrum research finds genetic ‘wrinkles’ in DNA could be a cause

TORONTO — In a lab at the Hospital for Sick Children in Toronto, scientists went on a hunt through the DNA of some 10,000 families — many whom have children with autism.

Through this research, they identified something they call “genetic wrinkles” in DNA itself, a breakthrough they believe could explain why some individuals find themselves on the autistic spectrum.

The hope is that this could be an important new clue into how to diagnose autism spectrum disorder (ASD) early, or even treat it.

New paper squares economic choice with evolutionary survival

If given the chance, a Kenyan herder is likely to keep a mix of goats and camels. It seems like an irrational economic choice because goats reproduce faster and thus offer higher near-term herd growth. But by keeping both goats and camels, the herder lowers the variability in growth from year to year. All of this helps increase the odds of household survival, which is essentially a gamble that depends on a multiplicative process with no room for catastrophic failure. It turns out, the choice to keep camels also makes evolutionary sense: families that keep camels have a much higher probability of long-term persistence. Unlike businesses or governments, organisms can’t go into evolutionary debt—there is no borrowing one’s way back from extinction.

How biological survival relates to economic choice is the crux of a new paper published in Evolutionary Human Sciences, co-authored by Michael Price, an anthropologist and Applied Complexity Fellow at the Santa Fe Institute, and James Holland Jones, a biological anthropologist and associate professor at Stanford’s Earth System Science department.

“People have wanted to make this association between evolutionary ideas and economic ideas for a long time,” Price says, and “they’ve gone about it quite a lot of different ways.” One is to equate the economic idea of maximizing utility—the satisfaction received from consuming a good—with the evolutionary idea of maximizing fitness, which is long-term reproductive success. “That utility equals fitness was simply assumed in a lot of previous work,” Price says, but it’s “a bad assumption.” The human brain evolved to solve proximate problems in ways that avoid an outcome of zero. In the Kenyan example, mixed herding diversifies risk. But more importantly, the authors note, the growth of these herds, like any biological growth process, is multiplicative and the rate of increase is stochastic.

Hydrogel mimics human brain with memorizing and forgetting ability

Hokkaido University researchers have found a soft and wet material that can memorize, retrieve, and forget information, much like the human brain. They report their findings in the journal Proceedings of the National Academy of Sciences (PNAS).

The learns things, but tends to forget them when the is no longer important. Recreating this dynamic process in manmade materials has been a challenge. Hokkaido University researchers now report a hydrogel that mimics the dynamic memory function of the brain: encoding information that fades with time depending on the memory intensity.

Hydrogels are flexible materials composed of a large percentage of water—in this case about 45%—along with other chemicals that provide a scaffold-like structure to contain the water. Professor Jian Ping Gong, Assistant Professor Kunpeng Cui and their students and colleagues in Hokkaido University’s Institute for Chemical Reaction Design and Discovery (WPI-ICReDD) are seeking to develop hydrogels that can serve biological functions.

Researchers develop an optical fiber made of gel derived from marine algae

An optical fiber made of agar has been produced at the University of Campinas (UNICAMP) in the state of São Paulo, Brazil. This device is edible, biocompatible and biodegradable. It can be used in vivo for body structure imaging, localized light delivery in phototherapy or optogenetics (e.g., stimulating neurons with light to study neural circuits in a living brain), and localized drug delivery.

Another possible application is the detection of microorganisms in specific organs, in which case the probe would be completely absorbed by the body after performing its function.

The research project, which was supported by São Paulo Research Foundation—FAPESP, was led by Eric Fujiwara, a professor in UNICAMP’s School of Mechanical Engineering, and Cristiano Cordeiro, a professor in UNICAMP’s Gleb Wataghin Institute of Physics, in collaboration with Hiromasa Oku, a professor at Gunma University in Japan.

‘Love hormone’ oxytocin could be used to treat cognitive disorders like Alzheimer’s

Scientists discover that oxytocin could be used to treat cognitive disorder like Alzheimer’s disease.


Alzheimer’s disease is a progressive disorder in which the nerve cells (neurons) in a person’s brain and the connections among them degenerate slowly, causing severe memory loss, intellectual deficiencies, and deterioration in motor skills and communication. One of the main causes of Alzheimer’s is the accumulation of a protein called amyloid β (Aβ) in clusters around neurons in the brain, which hampers their activity and triggers their degeneration.

Studies in animal models have found that increasing the aggregation of Aβ in the hippocampus—the brain’s main learning and memory center—causes a decline in the signal transmission potential of the neurons therein. This degeneration affects a specific trait of the neurons, called ‘,’ which is the ability of synapses (the site of signal exchange between neurons) to adapt to an increase or decrease in signaling activity over time. Synaptic plasticity is crucial to the development of learning and cognitive functions in the hippocampus. Thus, Aβ and its role in causing cognitive memory and deficits have been the focus of most research aimed at finding treatments for Alzheimer’s.

Now, advancing this research effort, a team of scientists from Japan, led by Professor Akiyoshi Saitoh from the Tokyo University of Science, has looked at oxytocin, a hormone conventionally known for its role in the female reproductive system and in inducing the feelings of love and well-being. “Oxytocin was recently found to be involved in regulating learning and memory performance, but so far, no previous study deals with the effect of oxytocin on Aβ-induced ,” Prof Saitoh says. Realizing this, Prof Saitoh’s group set out to connect the dots. Their findings are published in Biochemical and Biophysical Research Communication.

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