“These findings are disturbing. Suicide is one of the top 10 causes of death in the US right now, and it’s one of three causes that is actually increasing recently, so we do consider it a public health problem — and something that is all around us,” Schuchat said. The other two top 10 causes of death that are on the rise are Alzheimer’s disease and drug overdoses, she noted.

Suicide rates increased by 25% across the United States over nearly two decades ending in 2016, according to research published Thursday by the US Centers for Disease Control and Prevention. Twenty-five states experienced a rise in suicides by more than 30%, the government report finds.

More than half of those who died by suicide had not been diagnosed with a mental health condition, said Dr. Anne Schuchat, principal deputy director of the CDC.

Continue reading “US suicide rates increased more than 25% since 1999, CDC says” »

Neurotechnology startup CTRL-Labs hopes to create the first mass-market brain-computer interface using an electrode-studded wristband. We got an early taste of how it works.

It was a great pleasure to share latest data and insights with a fantastic community of researchers, engineers, innovators and investors last week, hosted by the Imperial College Centre for Neurotechnology in London. Hope you enjoy the overview slides!

Presentation by Alvaro Fernandez hosted by the Imperial College Centre for Neurotechnology in London.

Description: As seen in patent and investment trends, research findings and consumer/patient behaviors, Mental Health and Brain Enhancement are rapidly evolving in transformational ways which some call “empowering” and some “controversial.” Alvaro Fernandez, Editor-in-Chief of independent market research firm SharpBrains, will present and discuss the latest market data and forecasts on how digital platforms are poised to revolutionize brain & mental health diagnostics, monitoring, therapies and enhancement.

Continue reading “Why the Future of Brain Enhancement and Mental Health is Digital and Pervasive” »

The Neurogenesis Debate

Written by Nicholi Avery

On March 7 2018, a study was published in the highly esteemed journal Nature by an international team of scientists claiming that #neurogenesis starts to rapidly decline in the #human brain as early as 13 years old and becomes undetectable in adults. This rocked the scientific community as there has been a long-established theory that neurogenesis takes place throughout the course of life in the mammalian #brain. Until the 1990s, neurologists were practicing their profession under the doctrine established in the late 19th to early 20th century by the prominent histologist Ramon y Cajal, often referred to as a god of neuroscience;

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Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease.

Summary

While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and Drosophila models of GBA-related PD (GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. NAD+ precursors have been proposed to ameliorate agerelated metabolic decline and disease. We report that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons. Human neurons require nicotinamide phosphoribosyltransferase (NAMPT) to maintain the NAD+ pool and utilize NRK1 to synthesize NAD+ from NAD+ precursors. Remarkably, NR prevents the age-related dopaminergic neuronal loss and motor decline in fly models of GBA-PD.

Continue reading “NAD+ Precursor Has Therapeutic Potential Against Parkinsons Disease” »

Great news.

Fresh or frozen human blood samples can be directly transformed into patient-specific neurons to study disorders such as schizophrenia and autism, Stanford researchers find.

Johnson and Johnson recently announced that it was halting a clinical trial for a new Alzheimer’s drug after safety issues emerged. This latest failure adds to the dozens of large, costly clinical trials that have shown no effect in treating this devastating disease.

The growing list of failures should give us pause for thought – have we got the causes of Alzheimer’s all wrong?

In the first analysis of the disease, the German physician, Alois Alzheimer, noted odd changes in the brain of a patient who died of the condition. Alzheimer identified two kinds of protein aggregates that are not found in younger brains: plaques that are found between brain cells and tangles that are found inside brain cells.

Continue reading “Why Insulin Is a New Suspect in Alzheimer’s Disease” »

Very promising since “Identifying what changes are happening in the brain when interventions successfully reduce depressive symptoms could allow us to create more effective, pharmaceutical-free approaches to help alleviate depression in people who experience chronic traumatic brain injury symptoms,” said study author Dr. Sandra Bond Chapman, founder and chief director of the Center for BrainHealth.

Images show prefrontal connectivity patterns after cognitive training in individuals who suffered traumatic brain injury. Kihwan Han et al (2018) _____ Cognitive training reduces depression, rebuilds injured brain structure & connectivity after traumatic brain injury (UT-Dallas release): “New research from the Center.

MIT researchers, working with scientists from Brigham and Women’s Hospital, have developed a new way to power and communicate with devices implanted deep within the human body. Such devices could be used to deliver drugs, monitor conditions inside the body, or treat disease by stimulating the brain with electricity or light.

The implants are powered by radio frequency waves, which can safely pass through human tissues. In tests in animals, the researchers showed that the waves can power devices located 10 centimeters deep in tissue, from a distance of 1 meter.

Continue reading “Wireless System Can Power Smart Devices Inside the Body” »