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The cutting-edge ‘KNasa Chef Knife’ is twice as sharp as other blades and stays sharp for five times longer.

The brains behind it claim it is the first true innovation in knife making in over 200 years.

The knife is made from an ultra-hard alloy developed by scientists at the California Institute of Technology (Caltech) and has been tested by engineers at NASA.

“Everybody here’s been vaccinated anyway”

“It’s a hoax”

Given that I can’t see the man talking’s mouth due to his face mask I have trouble blindly assuming this video is true. Is that my own cognitive dissonance though? Was awfully weird to see Pence walking around the Mayo Clinic face mask less. Almost seemed to me like he felt like he had protection against the virus. Was it just his religious faith that inspired him to act with such little caution or is there something big here that we aren’t being told?


“Like you often have to do in science, we first hit the problem with a hammer to see how the system breaks, then backtrack from there,” Simpson said.

By that she means that in order to determine if the gut microbiome influenced drug addiction, they first needed to compare an organism with a normal gut microbiome to one without. To do that, the researchers gave some rats antibiotics that depleted 80 percent of their gut microbes. All of the rats — those with and without gut microbes — were dependent on the prescription opioid pain reliever oxycodone. Then some of the rats from each group went into withdrawal.

“To me, the most surprising thing was that the rats all seemed the same on the surface,” George said. “There weren’t any major changes in the pain-relieving effect of opioids, or symptoms of withdrawal or other behavior between the rats with and without gut microbes.”

It wasn’t until the team looked at the rats’ brains that they saw a significant difference. The typical pattern of neuron recruitment to different parts of the brain during intoxication and withdrawal was disrupted in rats that had been treated with antibiotics, and thus lacked most of their gut microbes. Most notably, during intoxication, rats with depleted gut microbes had more activated neurons in the regions of the brain that regulate stress and pain (periaqueductal gray, locus coeruleus) and regions involved in opioid intoxication and withdrawal (central amygdala, basolateral amygdala). During withdrawal, microbe-depleted rats had fewer activated neurons in the central amygdala, as compared to rats with normal gut microbiomes.

“It was many months of counting black dots,” Simpson said. “But in the end it became clear that, at least in rats, gut microbes alter the way the brain responds to drugs.”

That shift could affect behavior, she explained, because a decrease in neurons recruited in the central amygdala could result in fewer withdrawal symptoms, which can in turn lead to a higher risk of drug abuse.

A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major factor in the age-related decline of cognitive and motor functions, this discovery presents exciting new possibilities for longevity research.

Neurovascular coupling

While the human brain is the evolutionary advantage that brought us to where we are today, operating this machine requires considerable resources. Our cerebral blood flow (CBF) accounts for 15% of cardiac output and 20% of resting total oxygen consumption, even though the brain itself comprises just 2% of body mass. CBF has to be constantly redirected to the regions of the brain that are currently active, and NVC is the mechanism in charge of this complex operation. Importantly, the CBF/cardiac output ratio decreases with age [2].

Can we study AI the same way we study lab rats? Researchers at DeepMind and Harvard University seem to think so. They built an AI-powered virtual rat that can carry out multiple complex tasks. Then, they used neuroscience techniques to understand how its artificial “brain” controls its movements.

Today’s most advanced AI is powered by artificial neural networks —machine learning algorithms made up of layers of interconnected components called “neurons” that are loosely inspired by the structure of the brain. While they operate in very different ways, a growing number of researchers believe drawing parallels between the two could both improve our understanding of neuroscience and make smarter AI.

Now the authors of a new paper due to be presented this week at the International Conference on Learning Representations have created a biologically accurate 3D model of a rat that can be controlled by a neural network in a simulated environment. They also showed that they could use neuroscience techniques for analyzing biological brain activity to understand how the neural net controlled the rat’s movements.