A new study provides the best evidence to date that the connection patterns between various parts of the human brain can tell scientists the specialized functions of each region.
Previous research has shown the relationship between connectivity and brain function for just one or a few functions, such as perception or social interactions.
But this study goes further by providing a “bird’s eye view” of the whole brain and its many functions, said Kelly Hiersche, lead author of the study and doctoral student in psychology at The Ohio State University.
Difficulty completing everyday tasks. Failing memory. Unusually poor concentration. For many people living with schizophrenia, cognitive challenges are part of daily life. Alongside well-known symptoms such as hallucinations and delusions, these difficulties can make it hard to live the life they want. That is why researchers at the University of Copenhagen are working to find ways to prevent such symptoms—and they may now be one step closer.
In a new study, researchers discovered that a specific type of brain cell is abnormally active in mice displaying schizophrenia-like behavior. When the researchers reduced the activity of these cells, the mice’s behavior changed. The findings are published in the journal Neuron.
“Current treatments for cognitive symptoms in patients with diagnoses such as schizophrenia are inadequate. We need to understand more about what causes these cognitive symptoms that are derived from impairments during brain development. Our study may be the first step toward a new, targeted treatment that can prevent cognitive symptoms,” says Professor Konstantin Khodosevich from the Biotech Research and Innovation Center at the University of Copenhagen, and one of the researchers behind the study.
An international research team, led by Shinghua Ding at the University of Missouri, has identified a previously unknown genetic disease that affects movement and muscle control.
The disease—called Mutation in NAMPT Axonopathy (MINA) syndrome—causes damage to motor neurons, the nerve cells that send signals from the brain and spinal cord to muscles. It’s the result of a rare genetic mutation in a critical protein known as NAMPT, which helps the body’s cells make and use energy. When this protein doesn’t work as it should, cells can’t produce enough energy to stay healthy.
Over time, this lack of energy causes the cells to weaken and die, and leads to symptoms such as muscle weakness, loss of coordination and foot deformities—which can worsen over time. In severe cases, patients may eventually need a wheelchair.
Small cell lung cancer often metastasizes to the brain. A Stanford Medicine-led study shows the cancer cells form synapses with neurons, and signaling across these synapses encourages tumor growth.
When you’re a teenager, it’s easy to feel like the world is watching your every mistake. For some kids, that sense of self‐consciousness fades as they grow up. For others, it deepens into full‐blown anxiety.
A new study led by researchers at the USC Dornsife College of Letters, Arts and Sciences may help explain why—and could eventually make it easier to spot teens most at risk before anxiety takes hold.
The research, published in JAMA Network Open, found that combining two kinds of brain scans can better predict which teens are likely to experience greater anxiety as they get older. The work sheds new light on how the adolescent brain responds to mistakes and why those responses vary from person to person.
*This video was recorded at ‘Paths to Progress’ at LabWeek hosted by Protocol Labs & Foresight Institute.*
Protocol Labs and Foresight Institute are excited to invite you to apply to a 5-day mini workshop series to celebrate LabWeek, PL’s decentralized conference to further public goods. The theme of the series, Paths to Progress, is aimed at (re)-igniting long overdue progress in longevity bio, molecular nanotechnology, neurotechnology, crypto & AI, and space through emerging decentralized, open, and technology-enabled funding mechanisms.
*This mini-workshop is focused on Paths to Progress in Molecular Nanotechnology* Molecular manufacturing, in its most ambitious incarnation, would use programmable tools to bring together molecules to make precisely bonded components in order to build larger structures from the ground up. This would enable general-purpose manufacturing of new materials and machines, at a fraction of current waste and price. We are currently nowhere near this ambitious goal. However, recent progress in sub-fields such as DNA nanotechnology, protein-engineering, STM, and AFM provide possible building blocks for the construction of a v1 of molecular manufacturing; the molecular 3D printer. Let’s explore the state of the art and what type of innovation mechanisms could bridge the valley of death: how might we update the original Nanotech roadmap; is a tech tree enough? how might we fund the highly interdisciplinary progress needed to succeed: FRO vs. DAO?
