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Category: neuroscience – Page 69

Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer

Individuals with retinal degenerative diseases struggle to restore vision due to the inability to regenerate retinal cells. Unlike cold-blooded vertebrates, mammals lack Müller glia (MG)-mediated retinal regeneration, indicating the limited regenerative capacity of mammalian MG. Here, we identify prospero-related homeobox 1 (Prox1) as a key factor restricting this process. Prox1 accumulates in MG of degenerating human and mouse retinas but not in regenerating zebrafish. In mice, Prox1 in MG originates from neighboring retinal neurons via intercellular transfer. Blocking this transfer enables MG reprogramming into retinal progenitor cells in injured mouse retinas. Moreover, adeno-associated viral delivery of an anti-Prox1 antibody, which sequesters extracellular Prox1, promotes retinal neuron regeneration and delays vision loss in a retinitis pigmentosa model. These findings establish Prox1 as a barrier to MG-mediated regeneration and highlight anti-Prox1 therapy as a promising strategy for restoring retinal regeneration in mammals.

Recovery for mammalian retinal degeneration is limited by a lack of Müller glia (MG)-mediated regeneration. Here authors show blocking Prox1 accumulation and intercellular transfer from retinal neurons enables MG reprogramming of retinal progenitor cells, promotes retinal neuron regeneration, and delays vision loss.

Why can’t we have childhood memories?

Though we learn so much during our first years of life, we can’t, as adults, remember specific events from that time. Researchers have long believed we don’t hold onto these experiences because the part of the brain responsible for saving memories — the hippocampus — is still developing well into adolescence and just can’t encode memories in our earliest years. But new Yale research finds evidence that’s not the case.

In a study, the researchers showed infants new images and later tested whether they remembered them. When an infant’s hippocampus was more active upon seeing an image the first time, they were more likely to appear to recognize that image later.

The findings, published in Science, indicate that memories can indeed be encoded in our brains in our first years of life. And the researchers are now looking into what happens to those memories over time.

Quantum Physics Suggests That Death Doesn’t Exist And It Is Probably Just An Illusion

Since the beginning of time, man has been interested in what happens after death.

Although there are numerous traditional answers to this question, it’s possible that scholars have added countless more ideas merely to provide some variation.

According to Robert Lanza, M.D., death is just a doorway to an endless number of universes. Furthermore, according to Lanza, everything that may possibly happen in our lifetime has already happened. He continues by saying that death does not exist in these situations because all of these possibilities are happening at the same time. We only connect our consciousness to our physical bodies because of the energy that flows through our brains.

Immune System Overactivity May Drive Mental Illness

New research from the University of Bristol has uncovered striking links between immune system proteins and neuropsychiatric conditions, including schizophrenia, depression, and Alzheimer’s disease. By analyzing large genetic datasets using Mendelian randomisation, scientists identified 29 immune-related proteins potentially playing a causal role in these disorders.

The findings suggest that mental health conditions may not be isolated to the brain but involve the entire body, potentially reshaping future treatment strategies. This video explores how inflammation and immune pathways could be the next frontier in neuropsychiatric care.

#mentalhealth #immunesystem #neuroscience #health #psychology #depression

Study finds flourishing doesn’t always mean happiness

Flourishing is more than just being happy, and a new global study finds some countries are doing better than others when it comes to overall well-being.

Take it from researchers at Baylor and Harvard universities, who unveiled a study Wednesday that included more than 207,000 people from 22 countries and Hong Kong. The study is published in the journal Nature Mental Health.

Their Global Fluorishing Study looked at six areas of well-being: happiness, health, meaning, character, relationships and financial security, CNN reported.