Researchers have mapped hundreds of semantic categories to the tiny bits of the cortex that represent them in our thoughts and perceptions. What they discovered might change our view of memory.
Category: neuroscience – Page 693
Researchers introduce into human cells a genetic mutation that protects against Alzheimer’s disease
𝐌𝐞𝐝𝐢𝐜𝐚𝐥𝐗𝐩𝐫𝐞𝐬𝐬:
The Neuro-Network.
𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝐢𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐞 𝐢𝐧𝐭𝐨 𝐡𝐮𝐦𝐚𝐧 𝐜𝐞𝐥𝐥𝐬 𝐚 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐦𝐮𝐭𝐚𝐭𝐢𝐨𝐧 𝐭𝐡𝐚𝐭 𝐩𝐫𝐨𝐭𝐞𝐜𝐭𝐬 𝐚𝐠𝐚𝐢𝐧𝐬𝐭 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 𝐝𝐢𝐬𝐞𝐚𝐬𝐞
𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙛𝙧𝙤𝙢 𝙩𝙝𝙚 𝙐𝙣𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙚́ 𝙇𝙖𝙫𝙖𝙡 𝙁𝙖𝙘𝙪𝙡𝙩𝙮 𝙤𝙛 𝙈𝙚𝙙𝙞𝙘𝙞𝙣𝙚 𝙖… See more.
Researchers from the Université Laval Faculty of Medicine and CHU de Québec–Université Laval Research Center have successfully edited the genome of human cells grown in vitro to introduce a mutation providing protection against Alzheimer’s disease. The details of this breakthrough were recently published in The CRISPR Journal.
“Some genetic mutations increase the risk of developing Alzheimer’s disease, but there is a mutation that reduces this risk,” says lead author Professor Jacques-P. Tremblay. “This is a rare mutation identified in 2012 in the Icelandic population. The mutation has no known disadvantage for those who carry it and reduces the risk of developing Alzheimer’s disease. Using an improved version of the CRISPR gene editing tool, we have been able to edit the genome of human cells to insert this mutation.”
Animal Rights Org Bares Teeth in Faceoff With Elon Musk Over Brain Research
The activist Physicians Committee for Responsible Medicine claims that macaque monkeys endured “extreme suffering” in a lab funded by Musk’s startup Neuralink.
How Left and Right Hippocampal CA1 Regions in the Mouse Brain Talk With Each Other
Researchers have uncovered neural circuitry that allows the CA1 region of th… See more.
Summary: Researchers have uncovered neural circuitry that allows the CA1 region of the hippocampus to communicate with its counterpart in the opposite hemisphere despite there being no connection between them.
Source: RIKEN
RIKEN neuroscientists have uncovered the neural circuitry that permits a subregion in the hippocampus to communicate with its counterpart in the opposite hemisphere despite there being no direct connection between them. While not directly applicable to people, this finding is important for informing future studies of the mouse brain.
The hippocampus is well known for its role in learning and memory. Vertebrates have two hippocampi: one on the left side of the brain and the other on the right. Each hippocampus has various subregions, including the CA1 and CA3 areas.
Could Astronauts Hibernate on Long Space Voyages?
The ESA is investigating hibernation technology that could allow astronauts to remain healthy during long-duration missions to Mars and beyond.
A renewed era of space exploration is upon us, and many exciting missions will be headed to space in the coming years. These include crewed missions to the Moon and the creation of permanent bases there. Beyond the Earth-Moon system, there are multiple proposals for crewed missions to Mars and beyond. This presents significant challenges since a one-way transit to Mars can take six to nine months. Even with new propulsion technologies like nuclear rockets, it could still take more than three months to get to Mars.
In addition to the physical and mental stresses imposed on the astronauts by the duration and long-term exposure to microgravity and radiation, there are also the logistical challenges these types of missions will impose (i.e., massive spacecraft, lots of supplies, and significant expense). Looking for alternatives, the European Space Agency (ESA) is investigating hibernation technology that would allow their astronauts to sleep for much of the voyage and arrive at Mars ready to explore.
This researcher was the subject of a recent study led by Alexander Choukér, a professor of Medicine at the Hospital of the Ludwig-Maximilians-University (LMU), and Thu Jennifer Ngo-Anh – a payload coordinator with the ESA’s Directorate of Human and Robotic Exploration Programs. The paper that describes their findings was recently published in the journal Neuroscience & Biobehavioral Reviews.
“Mini-Brains” Grown in a Lab Provide Clues About Early Life Origins of Schizophrenia
Multiple changes in brain cells during the first month of embryonic development may contribute to schizophrenia later in life, according to a new study by Weill Cornell Medicine investigators.
The researchers, whose study was published in Molecular Psychiatry, used stem cells collected from patients with schizophrenia and people without the disease to grow 3-dimensional “mini-brains” or organoids in the laboratory. By comparing the development of both sets of organoids, they discovered that a reduced expression of two genes in the cells stymies early development and causes a shortage of brain cells in organoids grown from patient stem cells.
“This discovery fills an important gap in scientists’ understanding of schizophrenia,” said senior author Dr. Dilek Colak, assistant professor of neuroscience at the Feil Family Brain and Mind Institute and the Center for Neurogenetics at Weill Cornell Medicine. Symptoms of schizophrenia typically develop in adulthood, but postmortem studies of the brains of people with the disease found enlarged cavities called ventricles and differences in the cortical layers that likely occurred early in life.
New brain imaging technique suggests memories are stored in the connections between your neurons
All memory storage devices, from your brain to the RAM in your computer, store information by changing their physical qualities. Over 130 years ago, pioneering neuroscientist Santiago Ramón y Cajal first suggested that the brain stores information by rearranging the connections, or synapses, between neurons.
Since then, neuroscientists have attempted to understand the physical changes associated with memory formation. But visualizing and mapping synapses is challenging to do. For one, synapses are very small and tightly packed together. They’re roughly 10 billion times smaller than the smallest object a standard clinical MRI can visualize. Furthermore, there are approximately 1 billion synapses in the mouse brains researchers often use to study brain function, and they’re all the same opaque to translucent color as the tissue surrounding them.
A new imaging technique my colleagues and I developed, however, has allowed us to map synapses during memory formation. We found that the process of forming new memories changes how brain cells are connected to one another. While some areas of the brain create more connections, others lose them.
Dr. Stephani Otte, Ph.D. — Chan Zuckerberg Initiative — Measuring Human Biology in Action
Measuring Human Biology in Action, To Cure, Prevent Or Manage All Diseases — Dr. Stephani Otte, Ph.D., Science Program Officer, Imaging, Chan Zuckerberg Initiative.
Dr. Stephani Otte, Ph.D is Science Program Officer, Imaging, at the Chan Zuckerberg Initiative (https://chanzuckerberg.com/), who leads the organization’s Imaging program and is focused on the creation, dissemination, optimization, and standardization of transformative imaging technologies.
Prior to CZI, Dr. Otte was Director of Science at a neuro-technology / microscopy company, Inscopix, involved in accelerating brain science and innovating mini-scope microscope solutions for real-time mapping of the human brain and it’s circuits.
Dr. Otte received her Ph.D. in Neuroscience at the University of California, San Diego, and did postdoctoral fellowships in systems neuroscience at the Salk Institute and University of California, Berkeley.
The Chan Zuckerberg Initiative is an organization established and owned by Dr. Priscilla Chan and her husband, Facebook founder Mark Zuckerberg, with a focus on science, education, immigration reform, housing, criminal justice, and other local issues, with a mission to “build a more inclusive, just, and healthy future for everyone” and to “advance human potential and promote equality in areas such as health, education, scientific research and energy”.
The Neuroscience of Consciousness
𝐒𝐭𝐚𝐧𝐟𝐨𝐫𝐝 𝐄𝐧𝐜𝐲𝐜𝐥𝐨𝐩𝐞𝐝𝐢𝐚 𝐨𝐟 𝐏𝐡𝐢𝐥𝐨𝐬𝐨𝐩𝐡𝐲:
The Neuro-Network.
𝐓𝐡𝐞 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐨𝐟 𝐂𝐨𝐧𝐬𝐜𝐢𝐨𝐮𝐬𝐧𝐞𝐬𝐬.
First published Tue Oct 9, 2018.
Conscious experience in humans depends on brain activity, so neuroscience will contribute to explaining consciousness. What would it be for neuroscience to explain consciousness? How much progress has neuroscience made in doing so? What challenges does it face? How can it meet those challenges? What is the philosophical significance of its findings? This entry addresses these and related questions.
To bridge the gulf between brain and consciousness, we need neural data, computational and psychological models, and philosophical analysis to identify principles to connect brain activity to conscious experience in an illuminating way. This entry will focus on identifying such principles without shying away from the neural details. The notion of neuroscientific explanation here conceives of it as providing informative answers to concrete questions that can be addressed by neuroscientific approaches. Accordingly, the theories and data to be considered will be organized around constructing answers to two questions (see section 1.4 for more precise formulations):
