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Category: neuroscience – Page 603

Dr. Ana Maria Cuervo, M.D., Ph.D. — Modulating Autophagy To Promote Healthspan — Albert Einstein COM

Modulating Autophagy To Promote Healthspan — Dr. Ana Maria Cuervo, M.D., Ph.D., Albert Einstein College of Medicine.

Dr. Ana Maria Cuervo, M.D., Ph.D. (https://www.einsteinmed.edu/faculty/8784/ana-maria-cuervo/) is Co-Director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. She serves as a Professor in the Department of Developmental & Molecular Biology, and the Department of Medicine (Hepatology), and has the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases.

Dr. Cuervo studied medicine and pursued a Ph.D. in biochemistry and molecular biology at the University of Valencia, as well as post-doctoral work at Tufts, and in 2001 she started her laboratory at Einstein, where she studies the role of protein-degradation in aging and age-related disorders, with emphasis in neurodegeneration and metabolic disorders.

Dr. Cuervo’s group is interested in understanding how altered proteins can be eliminated from cells and their components recycled. Her group has linked alterations in lysosomal protein degradation (autophagy) with different neurodegenerative diseases including Parkinson’s, Alzheimer’s and Huntington’s disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible. Her lab has also pioneered studies demonstrating a tight link between autophagy and cellular metabolism. They described how autophagy coordinates glucose and lipid metabolism and how failure of different autophagic pathways with age contribute to important metabolic disorders such as diabetes or obesity.

Dr. Cuervo is considered a leader in the field of protein degradation in relation to biology of aging and has been invited to present her work in numerous national and international institutions, including name lectures as the Robert R. Konh Memorial Lecture, the NIH Director’s, the Roy Walford, the Feodor Lynen, the Margaret Pittman, the IUBMB Award, the David H. Murdock, the Gerry Aurbach, the SEBBM L’Oreal-UNESCO for Women in Science, the C. Ronald Kahn Distinguished Lecture and the Harvey Society Lecture. She has organized and chaired international conferences on protein degradation and on aging, belongs to the editorial board of scientific journals in this topic, and is currently co-editor-in-chief of Aging Cell.

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Brain stimulation leads to long-lasting improvements in memory

Memory boost

Using a non-invasive method of stimulating the brain known as transcranial alternating current stimulation (tACS), which delivers electrical currents through electrodes on the surface of the scalp, Reinhart’s team conducted a series of experiments on 150 people aged between 65 and 88. Participants carried out a memory task in which they were asked to recall lists of 20 words that were read aloud by an experimenter. The participants underwent tACS for the entire duration of the task, which took 20 minutes.

After four consecutive days of this protocol, participants who received high-frequency stimulation of the dorsolateral prefrontal cortex had an improved ability to remember words from the beginning of the lists, a task that depends on long-term memory. Low-frequency zaps to the inferior parietal lobe enhanced participants’ recall of items later in the lists, which involves working memory. Participants’ memory performance improved over the four days — and the gains persisted even a month later. Those who had the lowest levels of general cognitive function before the study experienced the largest memory improvements.

Decrease Your Risk of Cognitive Decline and Dementia — Avoid These 8 Controllable Risk Factors

According to recent Baycrest research, adults without dementia risk factors like smoking, diabetes, or hearing loss had brain health comparable to that of those who are 10 to 20 years younger than them. According to the research, only one dementia risk factor can age a person’s cognition by up to three years.

“Our results suggest lifestyle factors may be more important than age in determining someone’s level of cognitive functioning. This is great news since there’s a lot you can do to modify these factors, such as managing diabetes, addressing hearing loss, and getting the support you need to quit smoking,” says Dr. Annalise LaPlume, Postdoctoral Fellow at Baycrest’s Rotman Research Institute (RRI) and the study’s lead author.

The research is one of the first to look at lifestyle risk factors for dementia across the entire lifespan.

The Stream of Consciousness and Personal Identity

Lastly, there is the concern that this is all whimsically unimportant, or worse, an obtuse disregard for more prosaic societal concerns. Some people may find debates of this sort to be pedantic and even snobbish, given the justified concern that advanced futuristic technologies are likely to benefit wealthy elites long before they trickle down to the masses. Worse, some people may expect that such technologies are likely impossible and that such metaphysical navelgazing is an ivory tower distraction in a world of real problems and challenges. To that reaction I say the importance is not necessarily in determining the prospects of technological and medical marvels that reside far in the future, if ever. The more relevant issue, and the reason I have committed so much of my life to contemplating and writing about these questions, is that we profoundly desire the most accurate model possible of reality and understanding of the human condition. Ultimately, we want to understand ourselves as conscious beings in the universe and to understand the nature of our existence. That is the real issue here, at least for me.

About the author

Keith Wiley is on the board of Carboncopies.org and is a fellow with The Brain Preservation Foundation. He holds a PhD in computer science from the University of New Mexico and works as a data scientist in Seattle, Washington. His book, A Taxonomy and Metaphysics of Mind-Uploading, is available on Amazon (https://www.amazon.com/dp/0692279849?tag=lifeboatfound-20?tag=lifeboatfound-20). His other writings, interviews, and videos about mind uploading are available on his website at http://keithwiley.com and elsewhere on the web.

Repetitive Transcranial Magnetic Stimulation (rTMS)

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment approved by the U.S. Food and Drug Administration for the treatment of clinical depression. The treatment is also being studied as a potential therapy for Alzheimer’s disease.

How rTMS works

Alzheimer’s disease is the most common cause of dementia, affecting millions of mostly elderly people around the world. In these people, the synaptic activity (connections between nerve cells) collapses and brain networks gradually falter, resulting in a decline in memory and the ability to think and learn.

Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation

This method could be helpful for elderly people.

Our brain has both short-term and long-term memory. While short-term memory helps us with things like remembering the bus number, long-term memory processes information for a long time. However, as we age, our memory does not work as well as it used to.

Electrical brain stimulation for 20 minutes on four consecutive days can improve two different types of memory in individuals 65 years and older for at least one month, a study published in the journal Nature Neuroscience reveals.

According to the study, this method could be beneficial for elderly people to maintain their errands very easily.

Reinhart et al. show that repetitive transcranial alternating current stimulation (tACS) of unique combinations of rhythmic frequency and stimulation locations produces selective and long-lasting improvements in verbal working memory and long-term memory in older adults.

Chaos synchronization between linearly coupled chaotic systems

Chaos, as a very interesting nonlinear phenomenon, has been intensively studied in the last three decades [10], [13]. It is found to be useful or has great potential in many disciplines such as in collapse prevention of power systems, biomedical engineering applications to the human brain and heart, thorough liquid mixing with low power consumption, secret communication technology, to name just a few [10], [13], [24].

Over the last decade, many new types of synchronization have appeared: chaotic synchronization [3], [4], lag synchronization [9], adaptive synchronization [2], phase synchronization [6], and generalized synchronization [9], to mention only a few. Since the discovery of chaos synchronization [3], there has been tremendous interest in studying the synchronization of chaotic systems [10]. Recently, synchronization of coupled chaotic systems has received considerable attention [1], [2], [5], [7]. Especially, a typical study of synchronization is the coupled identical chaotic systems [1], [6].

In 1963, Lorenz found the first classical chaotic attractor [12]. In 1999, Chen found another similar but topologically not equivalent chaotic attractor [11], [21], [22], as the dual of the Lorenz system, in a sense defined by Vanĕc̆ek and C̆elikovský [23]: The Lorenz system satisfies the condition a12 a21 0 while Chen system satisfies a12 a21 0. Very recently, Lü et al. produced a new chaotic system [14], [15], which satisfies the condition a12 a21 =0, thereby bridging the gap between the Lorenz and Chen attractors [15], [16], [17].

Using new technique, researchers make surprising discoveries about how flies’ brains respond to tastes

Taste matters to fruit flies, just as it does to humans: like people, the flies tend to seek out and consume sweet-tasting foods and reject foods that taste bitter. However, little is known about how sweet and bitter tastes are represented by the brain circuits that link sensation to behavior.

In a new study published in Current Biology, researchers at Brown University described how they developed a new imaging technique and used it to map the neural activity of fruit flies in response to sweet and bitter tastes.

“These results show that the way fly brains encode the taste of food is more complex than we had anticipated,” said study author Nathaniel Snell, who earned his Ph.D. in neuroscience from Brown in 2021 and conducted the research as part of his thesis.

‘No Other Material Behaves in This Way’: Scientist Identify a Compound With a Memory

It isn’t alive, and has no structures even approaching the complexity of the brain, but a compound called vanadium dioxide is capable of ‘remembering’ previous external stimuli, researchers have found.

This is the first time this ability has been identified in a material; but it may not be the last. The discovery has some pretty intriguing implications for the development of electronic devices, in particular data processing and storage.

“Here we report electronically accessible long-lived structural states in vanadium dioxide that can provide a scheme for data storage and processing,” write a team of researchers led by electrical engineer Mohammad Samizadeh Nikoo of École Polytechnique Fédérale de Lausanne in Switzerland in their paper.