The groundbreaking research that established the connection between Alzheimer’s.
Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.
A discovery made by researchers at the University of California, Irvine on how a certain protein is activated in tumor cells may lead to more effective treatments for some of the most deadly types of cancer. The finding, which was led by scientists at the School of Biological Sciences, may potentially result in treatment options for the especially dangerous melanoma and pancreatic adenocarcinoma, as well as the most common type of childhood brain cancer and adult skin cancer. The study was published in the journal Life Science Alliance.
The GLI1 protein, which is essential for cell development but has also been linked to a number of cancers, was the subject of the finding. The Hedgehog signaling pathway, also known as HH, usually activates GLI1. However, scientists have known for almost a decade that crosstalk, or interaction, between HH and the mitogen-activated protein kinase pathway, has a role in cancer.
“In some cases, proteins in one pathway can turn on proteins in another,” said lead author A. Jane Bardwell, a project scientist in UCI’s Department of Developmental and Cell Biology. “It’s a complex system. We wanted to understand the molecular mechanism that leads to GLI1 being activated by proteins in the MAPK pathway.”
The soft, polymer material acts like a brain, simultaneously sensing, thinking, and acting.
Summary: Dampening retromer activity slows down the trafficking of tau in neurodegenerative disorders, a new study reports.
Source: EPFL
Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease are associated with atypical proteins that form tangles in the brain, killing neurons. Neurobiologists at EPFL have now identified some key mechanisms underlying the formation of these tangles.
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Dr. Max More is a philosopher, writer, speaker and expert in Cryonics — the process of cryopreserving a body at the time of legal death in the hopes of reviving them in the future.
Theo talks with Dr. More about what actually happens when we die, the future of mankind, and if Theo would preserve his brain for science.
Dr. More is the Ambassador for Alcor Life Extension, a non-profit in Scottsdale, Arizona practicing cryonics. Max received a Doctorate in Philosophy in 1995 from the University of Southern California after completing a degree in Philosophy, Politics, and Economics from Oxford University.
Dr. Max More: https://www.maxmore.com/
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Summary: Study reveals how the element of surprise helps facilitate learning and memory retrieval.
Source: University of Manchester.
A study by University of Manchester neuroscientists into the effect of surprise on our memory has inadvertently discovered a method which might help us to perform better in exams.
Summary: Researchers have identified human-specific cell types in the prefrontal cortex. These unique cells may explain why humans are more susceptible to neuropsychiatric diseases than other primate species.
Source: Yale.
What makes the human brain distinct from that of all other animals—including even our closest primate relatives?