Lifeboat Foundation

Because of the coronavirus pandemic, most schools and universities around the world have had to close. Institutions have turned to services such as Zoom and Google Classroom, which have skyrocketed to being the most popular ones on the Play Store. Google’s service has become so famous that it just passed 50 million downloads.

AppBrain’s data shows the app was not even in the top 100 most popular at the beginning of the month but has rapidly spiked starting March 10 to reach the top 5 most popular ones in the US last week. In fact, the app is also being downloaded massively all around the world, as it’s amongst the most installed ones in Indonesia, Mexico, Canada, Finland, Italy, and Poland as well.

In times like this, it’s heartwarming to see there are free platforms readily available for teachers and students to keep learning and stay in touch, helping them continue to learn despite being on lockdown.

His work transformed the mind-set of scientists, launching a new field in the science of aging when he demonstrated that identifying and manipulating genes could lengthen life span.

Although Johnson’s research has led to drug development to slow the effects of age-related diseases, he has yet to find the secret to stop aging. Now the soft-spoken redheaded scientist is running out of time as he confronts his own mortality.

In 1987, scientist Tom Johnson’s team identified the first gene that affects aging. Today, he still works in his lab as he deals with incurable Lewy body dementia.

Continue reading “Researcher on aging confronts his own mortality” »

Though many negative repercussions of human immunodeficiency virus infection can be mitigated with the use of antiretroviral therapy (ART), one area where medical advances haven’t made as much progress is in the reduction of cognitive impacts. Half of HIV patients have HIV-associated neurocognitive disorders (HAND), which can manifest in a variety of ways, from forgetfulness and confusion to behavior changes and motor deficiencies.

To better understand the mechanisms underlying HAND, researchers from Penn’s School of Dental Medicine and Perelman School of Medicine and from the Children’s Hospital of Philadelphia (CHOP) brought together their complementary expertise to create a laboratory model system using three of the types of brain cells thought to be involved. Led by doctoral student Sean Ryan, who was co-mentored by Kelly Jordan-Sciutto of Penn Dental Medicine and Stewart Anderson of CHOP and Penn Medicine, the model recapitulates important features of how HIV infection and ART affect the brain.

“Frankly the models we generally use in the HIV field have a lot of weaknesses,” says Jordan-Sciutto, co-corresponding author on the paper, which appears in the journal Stem Cell Reports. “The power of this system is it allows us to look at the interaction between different cell types of human origin in a way that is more relevant to patients than other models.”

Stress or infection may prompt viruses hidden in our genome to stagger back to life, contributing to some cases of multiple sclerosis, diabetes and schizophrenia.

For the first time, scientists have reprogrammed cells from a 114-year-old woman into induced pluripotent stem cells (iPS cells), a move which they describe as a significant step toward understanding “the underlying mechanisms of extreme longevity and disease resistance.”

iPS cells are adult cells that have been genetically reprogrammed into an embryonic stem cell-like state and are able to give rise to any of the specialized cell types of the body, whether it’s neurons, blood cells, or heart cells.

Until this new project, researchers weren’t even certain whether they could create viable iPS cells from someone so elderly, let alone a supercentenarian. Now they have shown it’s possible to effectively make these aged cells resemble young pluripotent cells, the researchers believe they might have made a step towards the reversal of cellular aging.

Researcher from Peking University says new treatment could stop pathological memories.

Our body’s ability to detect disease, foreign material, and the location of food sources and toxins is all determined by a cocktail of chemicals that surround our cells, as well as our cells’ ability to ‘read’ these chemicals. Cells are highly sensitive. In fact, our immune system can be triggered by the presence of just one foreign molecule or ion. Yet researchers don’t know how cells achieve this level of sensitivity.

Now, scientists at the Biological Physics Theory Unit at Okinawa Institute of Science and Technology Graduate University (OIST) and collaborators at City University of New York have created a simple model that is providing some answers. They have used this model to determine which techniques a cell might employ to increase its sensitivity in different circumstances, shedding light on how the biochemical networks in our bodies operate.

“This model takes a complex biological system and abstracts it into a simple, understandable mathematical framework,” said Dr. Vudtiwat Ngampruetikorn, former postdoctoral researcher at OIST and the first author of the research paper, which was published in Nature Communications. “We can use it to tease apart how cells might choose to spend their energy budget, depending on the world around them and other cells they might be talking to.”

Continue reading “Making sense of cells” »

How does experience alter our perceptions? This adapted book excerpt from We Know It When We See It describes how the brain’s visual system rewires itself to make the best use of its neural resources.

It’s never too late to start strengthening your brain.