Two newly discovered genes have been linked to schizophrenia while a previously known gene associated with schizophrenia risk has also been linked to autism in a massive new study.
Scientists say the findings increase our understanding of brain diseases and could lead to new treatment targets.
Importantly, this is the first known investigation to look at the risk of schizophrenia in different groups of people, especially those with African ancestry. It revealed rare harmful variations in gene proteins raise the risk of schizophrenia in all ethnic groups.
A study led by Dr. Lige Leng of Xiamen University in China has identified a previously unknown trigger of aging in mice, and potentially humans. It involves the age-related reduction of a protein called menin Trusted Source in the brain’s hypothalamus.
According to The Alzheimer’s Association, the number of people age 65 and over living with Alzheimer’s now is nearly 7 million. That number is expected to rise to over 13 million by 2050.
Physician and best-selling author Dr. Ian Smith says it’s not known exactly what causes Alzheimer’s.
What if death was not the end? What if, instead of saying our final goodbyes to loved ones, we could freeze their bodies and bring them back to life once medical technology has advanced enough to cure their fatal illnesses? This is the mission of Tomorrow Biostasis, a Berlin-based startup that specializes in cryopreservation.
Cryopreservation, also known as biostasis or cryonics, is the process of preserving a human body (or brain) in a state of suspended animation, with the hope that it can be revived in the future when medical technology has advanced enough to treat the original cause of death. This may seem like science fiction, but it is a legitimate scientific procedure, and Tomorrow Biostasis is one of the few companies in the world that offers this service.
Dr Emil Kendziorra, co-founder and CEO of Tomorrow Biostasis explained that the goal of cryopreservation is to extend life by preserving the body until a cure can be found for the original illness. He emphasized that cryopreservation is not a form of immortality, but rather a way to give people a second chance at life.
With the aid of some sea slugs, University of Nebraska–Lincoln chemists have discovered that one of the smallest conceivable tweaks to a biomolecule can elicit one of the grandest conceivable consequences: directing the activation of neurons.
Their discovery came from investigating peptides, the short chains of amino acids that can transmit signals among cells, including neurons, while populating the central nervous systems and bloodstreams of most animals. Like many other molecules, an amino acid in a peptide can adopt one of two forms that feature the same atoms, with the same connectivity, but in mirror-image orientations: L and D.
Chemists often think of those two orientations as the left and right hands of a molecule. The L orientation is by far the more common in peptides, to the point of being considered the default. But when enzymes do flip an L to a D, the seemingly minor about-face can turn, say, a potentially therapeutic molecule into a toxic one, or vice versa.
The relationship between the individual human subject and the world was once the central focus of Western philosophy. Modern neuroscience has instead tended to assume that the world is purely material and physical, and the problem of consciousness a question of how to generate thought from matter. Yet, we are no closer to solving the deep puzzle of consciousness and many argue that the American philosopher Thomas Nagel is right when he maintains that the question of consciousness ‘cannot be detached from subject and object’.
Is the notion that the world is purely material a fundamental mistake? Would we be more likely to unlock the mysteries of consciousness by once again adopting the framework of the subject and object? Or will slow, piecemeal advances in neuroscience and analytic philosophy eventually yield the answers that we have been searching for?
Revolutionary cognitive psychologist Donald Hoffman (joining us live from across the pond), neuroscientist Hannah Critchlow and philosopher Sam Coleman battle to unlock consciousness. Hosted by award-winning novelist Joanna Kavenna.
The living mycelium networks are capable of efficient sensorial fusion over very large areas and distributed decision making. The information processing in the mycelium networks is implemented via propagation of electrical and chemical signals en pair with morphological changes in the mycelium structure. These information processing mechanisms are manifested in experimental laboratory findings that show that the mycelium networks exhibit rich dynamics of neuron-like spiking behaviour and a wide range of non-linear electrical properties. On an example of a single real colony of Aspergillus niger, we demonstrate that the non-linear transformation of electrical signals and trains of extracellular voltage spikes can be used to implement logical gates and circuits.
Human Cyborg — We’ve all seen Cyborgs in Hollywood blockbusters. But it turns out these fictional beings aren’t so far-fetched.
Human Cyborg (2020) Director: Jacquelyn Marker. Writers: Kyle McCabe, Christopher Webb Young. Stars: Justin Abernethy, Robert Armiger, John Donoghue. Genre: Documentary. Country: United States. Language: English. Also Known As: Cyborg Revolution. Release Date: 2020 (United States)
Synopsis: We’ve all seen Cyborgs in Hollywood blockbusters. But it turns out these fictional beings aren’t so far-fetched. In fact, this episode features a true-to-life cyborg, who at four months of age, was the youngest American to be outfitted with a myoelectric hand. And at one ground-breaking engineering facility, engineers are developing biotechnologies that can even further enhance high-tech like this by giving mechanical prosthetics something incredible: the physical sensation of touch!
Other engineering firms are gearing up powerful exoskeletons that both rehabilitate and enhance the power of the human body… improving the lives of those with paralysis and transforming the work force.
But the real pivot is getting machines inside the body. An out-of-the-box ‘transhumanist’ featured in the episode installs a chip inside a person’s hand. It works as a key that unlocks doors, literally and figuratively.
However, brain-machine integration poses the biggest challenges, and the biggest rewards. Cutting-edge neuroscientists and technologists reveal how computer chips can directly interface with the human brain in ways that not only rehabilitate, but which can also ‘read thoughts’ in real-time.
Summary: Our native language may affect the way in which our brains are wired and underlie the way we think, a new study reports. Using neuroimaging to analyze neural connectivity in native German and native Arabic speakers, researchers found stronger connectivity between the right and left hemispheres in Arabic speakers, and stronger connectivity in the left hemisphere language area in German speakers.
Source: Max Planck Institute.
Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have found evidence that the language we speak shapes the connectivity in our brains that may underlie the way we think.
Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans. The study, to be published March 17 in the Journal of Experimental Medicine, uses a new, highly versatile form of CRISPR-based genome editing with the potential to correct a wide variety of disease-causing genetic mutations.
Researchers have previously used genome editing to restore the vision of mice with genetic diseases, such as Leber congenital amaurosis, that affect the retinal pigment epithelium, a layer of non-neuronal cells in the eye that supports the light-sensing rod and cone photoreceptor cells. However, most inherited forms of blindness, including retinitis pigmentosa, are caused by genetic defects in the neural photoreceptors themselves.
“The ability to edit the genome of neural retinal cells, particularly unhealthy or dying photoreceptors, would provide much more convincing evidence for the potential applications of these genome-editing tools in treating diseases such as retinitis pigmentosa,” says Kai Yao, a professor at the Wuhan University of Science and Technology.
