When we press our temples to soothe an aching head or rub an elbow after an unexpected blow, it often brings some relief. It is believed that pain-responsive cells in the brain quiet down when these neurons also receive touch inputs, say scientists at MIT’s McGovern Institute for Brain Research, who for the first time have watched this phenomenon play out in the brains of mice.

The team’s discovery, reported Nov. 6 in the journal Science Advances, offers researchers a deeper understanding of the complicated relationship between pain and touch and could offer some insights into chronic pain in humans.

“We’re interested in this because it’s a common human experience,” says McGovern investigator Fan Wang. “When some part of your body hurts, you rub it, right? We know touch can alleviate pain in this way.” But, she says, the phenomenon has been very difficult for neuroscientists to study.

Newborns need to store vast amounts of new information quickly as they learn to navigate the world. Silent synapses – the immature connections between neurons that have no neurotransmitter activity yet – are thought to be the hardware that allow this rapid information storage to occur early in life.

First discovered decades ago in newborn mice, these potential neurological intersections were thought to disappear as the animals aged. A recent study by researchers from MIT in the US has found this vanishing act might not be as extreme as initially presumed.

The team hadn’t set out to look specifically at these potential connections. Rather, they were continuing previous work on the locations of nerve-cell extensions called dendrites.

face_with_colon_three year 2020.

Billeh et al. systematically integrate multi-modal data about neuron types, connectivity, and sensory innervations to create biologically realistic models of the mouse primary visual cortex at two levels of resolution, shared freely as a community resource.