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Summary: Dampening retromer activity slows down the trafficking of tau in neurodegenerative disorders, a new study reports.

Source: EPFL

Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease are associated with atypical proteins that form tangles in the brain, killing neurons. Neurobiologists at EPFL have now identified some key mechanisms underlying the formation of these tangles.

https://youtu.be/3EnzFULP3nc

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Dr. Max More is a philosopher, writer, speaker and expert in Cryonics — the process of cryopreserving a body at the time of legal death in the hopes of reviving them in the future.

Theo talks with Dr. More about what actually happens when we die, the future of mankind, and if Theo would preserve his brain for science.

Dr. More is the Ambassador for Alcor Life Extension, a non-profit in Scottsdale, Arizona practicing cryonics. Max received a Doctorate in Philosophy in 1995 from the University of Southern California after completing a degree in Philosophy, Politics, and Economics from Oxford University.

Dr. Max More: https://www.maxmore.com/

Due to a rare genetic mutation, Aliria Rosa Piedrahita de Villegas should have had Alzheimer’s.

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

The flow of time from the past to the future is a central feature of how we experience the world. But precisely how this phenomenon, known as the arrow of time, arises from the microscopic interactions among particles and cells is a mystery—one that researchers at the CUNY Graduate Center Initiative for the Theoretical Sciences (ITS) are helping to unravel with the publication of a new paper in the journal Physical Review Letters. The findings could have important implications in a variety of disciplines, including physics, neuroscience, and biology.

Fundamentally, the of arises from the second law of thermodynamics: the principle that microscopic arrangements of physical systems tend to increase in randomness, moving from order to disorder. The more disordered a system becomes, the more difficult it is for it to find its way back to an ordered state, and the stronger the arrow of time. In short, the universe’s tendency toward disorder is the fundamental reason why we experience time flowing in one direction.

“The two questions our team had were, if we looked at a particular system, would we be able to quantify the strength of its arrow of time, and would we be able to sort out how it emerges from the micro scale, where cells and interact, to the whole system?” said Christopher Lynn, the paper’s first author and a postdoctoral fellow with the ITS program. “Our findings provide the first step toward understanding how the arrow of time that we experience in emerges from these more microscopic details.”