Researchers at the University of Colorado Anschutz find that the overexpression of a gene improves learning and memory in Alzheimer’s.
Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.
Nothing in biology makes sense except in the light of evolution. The gradualism of evolution has explained and dissolved life’s mysteries—life’s seemingly irreducible complexity and the illusion that living things possess some sort of mysterious vitalizing essence. So, too, evolution is likely to be key to demystifying the seemingly inexplicable, ethereal nature of consciousness.
First, what does it even mean to say that “Nothing in biology makes sense except in the light of evolution”? If the chosen topic is human consciousness, Martin Luther King and Mother Teresa come quickly to mind. But then what does the term “evolution” contribute to the discussion of the origin of human consciousness? Is it something useful or something theorists are stuck with, come what may?
Science theories should make predictions. Who predicted either King or Mother Teresa?
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Hello and welcome! My name is Anton and in this video, we will talk about incredible discoveries about the human brain.
Links:
https://www.pnas.org/doi/full/10.1073/pnas.2204900119
https://www.nature.com/articles/s41586-022-05277-w.
https://en.wikipedia.org/wiki/ARHGAP11B
https://www.scienceinpublic.com.au/corticallabs.
https://www.nature.com/articles/s41586-019-1654-9
Synthetic cells: https://youtu.be/OxVZPKmm58M
#brain #biology #neuroscience.
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Summary: Study reveals a signaling pathway that controls the formation of synapses between pyramidal neurons and inhibitory neurons expressing the parvalbumin protein.
Source: King’s College London.
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has demonstrated that brain wiring requires the control of local protein synthesis at the level of specific synapse types.
Magnetic fields are all around us. They exist whenever there is electric current and have been used in various aspects of medicine for decades. Today, magnetic fields are used in applications including magnetic resonance imaging (MRI), bone fracture repair, wound healing and pain reduction.
Taking things a step further, US startup EMulate Therapeutics has developed a unique magnetic field technology that has been shown to replicate the effect of drugs in humans and animal models – all without the presence of chemicals. Having spun-out companies in cancer, pain management and beyond, the company is seeking partners for longevity applications of its technology.
Longevity. Technology: The concept behind EMulate’s approach is mind-boggling. The company “records” the electromagnetic signature of specific molecules and is then able to use those recordings to effect changes in cellular behaviour, without using chemicals. In its most advanced programme, EMulate’s technology has completed feasibility clinical trials for adults and children with terminal brain cancer, using a recording derived from chemotherapy drug paclitaxel. We caught up with EMulate’s CEO Chris Rivera to find out more.
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Mathematics and sex are deeply intertwined. From using mathematics to reveal patterns in our sex lives, to using sex to prime our brain for certain types of problems, to understanding them both in terms of the evolutionary roots of our brain, Dr Clio Cresswell shares her insight into it all.
Dr Clio Cresswell is a Senior Lecturer in Mathematics at The University of Sydney researching the evolution of mathematical thought and the role of mathematics in society. Born in England, she spent part of her childhood on a Greek island, and was then schooled in the south of France where she studied Visual Art. At eighteen she simultaneously discovered the joys of Australia and mathematics, following on to win the University Medal and complete a PhD in mathematics at The University of New South Wales. Communicating mathematics is her field and passion. Clio has appeared on panel shows commenting, debating and interviewing; authored book reviews and opinion pieces; joined breakfast radio teams and current affair programs; always there highlighting the mathematical element to our lives. She is author of Mathematics and Sex.
TEDxSydney is an independently organised event licensed from TED by longtime TEDster, Remo Giuffré (REMO General Store) and organised by his General Thinking network of fellow thinkers and other long time collaborators.
University of Saskatchewan (USask) researchers have developed a new method of killing brain cancer cells while preserving the delicate tissue around it. The technique also has a remarkable side-benefit: making chemotherapy treatment of brain cancer suddenly possible.
The technique involves placing long needles through the skull and sending pulses of electrical current into a glioblastoma tumor—the pernicious variety of brain cancer that caused Tragically Hip frontman Gord Downie’s death.
“A safer and more effective cancer treatment may be clinically possible,” said Dr. Mike Moser (MD), USask College of Medicine general surgery researcher and co-author of a study published recently in the Journal of Biomechanical Engineering.
ETH Zurich researchers have found that a set of proteins have different shapes in the spinal fluid of healthy individuals and Parkinson’s patients. These could be used in the future as a new type of biomarker for this disease.
Many human diseases can be detected and diagnosed using biomarkers in blood or other body fluids. Parkinson’s disease is different: to date, there is no such biomarker being used in the clinicto indicate this neurodegenerative disease.
A team led by ETH Zurich Professor Paola Picotti could now help to close this gap. In a study just published in the journal Nature Structural and Molecular Biology, the researchers present 76 proteins that might serve as biomarkers for the detection of Parkinson’s disease.
Scientists identified a type of immune cell that helps clear waste products in the brain, suggesting new strategies for preventing and treating Alzheimer’s disease and related disorders.
A chemical called kynurenic acid may play a role in diseases characterised by cognitive impairments or psychosis, including schizophrenia, Alzheimer’s disease and bipolar disorder. Newly developed drugs that reduce this acid in the brain show promise in reducing symptoms of these conditions.
