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Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer’s disease in a mouse model, according to a new study publishing March 7 in the open access journal PLOS Biology by Rui Zhang of Air Force Medical University in Xian, Shaanxi, China. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a new target for treatment of Alzheimer’s disease.

A presumed trigger for the development of Alzheimer’s disease is the accumulation of proteinaceous, extracellular amyloid-beta plaques in the brain. High levels of amyloid-beta in mice leads to neurodegeneration and cognitive symptoms reminiscent of human Alzheimer’s disease, and reduction of amyloid-beta is a major goal in development of new treatments.

One potential pathway for getting rid of amyloid-beta is the migration of blood-derived myeloid cells into the brain, and their maturation into macrophages, which, along with resident microglia, can consume amyloid-beta. That migration is a complex phenomenon controlled by multiple interacting players, but a potentially important one is the methylation of messenger RNA within the myeloid cells.

New technologies can greatly advance research in various fields, including medicine and neuroscience. In recent years, for instance, engineers have created increasingly sophisticated devices to record brain activity and other biological signals with high precision.

A multi-disciplinary research team at University of California, Los Angeles (UCLA) and other institutes in the U.S. have recently developed the Neuro-stack, a new wearable technology that can record the activity of single neurons in the brain as a human being is walking or moving. This device, presented in a paper published in Nature Neuroscience, could help to gather valuable insight about neuronal activity during walking, while also potentially improving treatments for brain disorders.

“Our study was motivated by the need for smaller size and more flexible devices for clinical neuroscience,” Dejan Markovic, one of the researchers who carried out the study, told Medical Xpress. “Our primary objectives were to make a device that is small enough to be wearable, for mobile experiments, and to provide broadband recordings including local field potentials and single units.”

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My name is Artem, I’m a computational neuroscience student and researcher. In this video we talk about the concept of critical point – how the brain might optimize information processing by hovering near a phase transition.

Continue reading “Brain Criticality — Optimizing Neural Computations” »

Recently, Scientists have outlined a plan for a potentially revolutionary new area of research called “organoid intelligence”, which aims to create “biocomputers”, where brain cultures grown in the lab are coupled to real-world sensors and input/output devices.

The term now covers all types of technology and innovation designed to address health issues that solely, or disproportionately, impact women’s health, from menstrual cycle tracking apps and sexual wellness products to cardiovascular medical devices and mental health therapies.

Giving FemTech its own name helped the community of people working in the sector to find each other, but also gave investors reassurance about where they were putting their money, Tin said.

“It’s a little easier to say you’re invested in FemTech than, you know, a company that helps women not pee their pants … It kind of bridged the gap over to men as well, which was important, still is important, because so many investors are men.”

A team of biologists has discovered how to awaken neural stem cells and reactivate them in adult mice.

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

<em>Science Advances</em> is a peer-reviewed, open-access scientific journal that is published by the American Association for the Advancement of Science (AAAS). It was launched in 2015 and covers a wide range of topics in the natural sciences, including biology, chemistry, earth and environmental sciences, materials science, and physics.

Your thoughts, emotions and behaviours arise from the complex network of electric activity in your brain. But what can we do when we need to tweak it?

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A new multimodal artificial intelligence model from Microsoft called Kosmos-1 is able to process both text and visual data to the point of passing a visual IQ test with 26 percent accuracy, and researchers say this is a step towards AGI. Stable Diffusion AI can now read brain waves to reconstruct images that people are thinking about. Stanford has created a world record brain computer interface device with the help of AI to allow patients to type 62 words per minute with their thoughts.

AI News Timestamps:
0:00 Microsoft Kosmos-1 AI & AGI
3:34 AI Neuroscience Tech Reads Brain Waves.
5:43 AI & BCI Breaks Record.

#technology #tech #ai

Brave new world let’s create happiness for everyone by putting microelectrode arrays in our brains but be careful not to create a situation like death by ecstacy by Larry Niven.

In the brain, pleasure is generated by a handful of brain regions called, “hedonic hotspots.” If you were to stimulate these regions directly, you would likely feel pleasurable sensations. However, not all of the hedonic hotspots are the same–some generate the raw sensations of pleasure whereas others are responsible for consciously interpreting and elaborating on the raw pleasure produced by the other hotspots. In this video, in addition to exploring the neuroscience of pleasure, we’ll see how understanding pleasure, happiness, meaning, and purpose can help us live better lives.

Continue reading “PLEASURE GENERATORS in the Brain: The Neuroscience of Pleasure Explained” »