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White matter may aid recovery from spinal cord injuries: Study

Injuries, infection and inflammatory diseases that damage the spinal cord can lead to intractable pain and disability. Some degree of recovery may be possible. The question is, how best to stimulate the regrowth and healing of damaged nerves.

At the Vanderbilt University Institute of Imaging Science (VUIIS), scientists are focusing on a previously understudied part of the brain and —white matter. Their discoveries could lead to treatments that restore through the targeted delivery of electromagnetic stimuli or drugs.

As in the brain, the spinal cord is made up nerve cell bodies (gray matter), which process sensation and control voluntary movement, and axons (white matter), fibers that connect nerve cells and which project to the rest of the body.

Young Adult Health Habits Linked to Midlife Cognitive Decline

A UCSF study reveals that higher inflammation levels in young adults are associated with poorer cognitive performance in midlife, underscoring the importance of lifestyle choices in reducing inflammation and preventing cognitive decline.

Higher levels of inflammation in young adults, associated with factors like obesity, physical inactivity, chronic illness, stress, and smoking, are linked to decreased cognitive function in midlife, according to a new study from UC San Francisco.

Researchers previously linked higher inflammation in older adults to dementia, but this is one of the first studies to connect inflammation in early adulthood with lower cognitive abilities in midlife.

Brain Cancer Breakthrough: New Therapy Destroys Glioblastoma in Recently Unveiled Pathway

Researchers have discovered a new pathway used by cancer cells to infiltrate the brain and developed a promising therapy that targets this pathway with CAR T cells.

Their study showed significant preclinical success in increasing survival and eradicating tumors in animal models of glioblastoma and other brain cancers.

A team of Canadian and American research groups led by the Singh Lab at McMaster University have discovered a new pathway that is used by cancer cells to infiltrate the brain. The research also reveals a new therapy that shows promise in blocking and killing these tumors.

Brain activity associated with specific words is mirrored between speaker and listener during a conversation, data show

When two people interact, their brain activity becomes synchronized, but it was unclear until now to what extent this “brain-to-brain coupling” is due to linguistic information or other factors, such as body language or tone of voice.

Researchers report August 2 in the journal Neuron that brain-to-brain coupling during can be modeled by considering the words used during that conversation, and the context in which they are used.

“We can see linguistic content emerge word-by-word in the speaker’s brain before they actually articulate what they’re trying to say, and the same linguistic content rapidly reemerges in the listener’s brain after they hear it,” says first author and neuroscientist Zaid Zada of Princeton University.

How epigenetics influence memory formation

When we form a new memory, the brain undergoes physical and functional changes known collectively as a “memory trace.” A memory trace represents the specific patterns of activity and structural modifications of neurons that occur when a memory is formed and later recalled.

But how does the brain “decide” which neurons will be involved in a ? Studies have suggested that the inherent excitability of neurons plays a role, but the currently accepted view of learning has neglected to look inside the command center of the neuron itself, its nucleus. In the nucleus, there seems to be another dimension altogether that has gone unexplored: epigenetics.

Inside every cell of a given living organism, the genetic material encoded by the DNA is the same, yet the various cell types that make up the body, like , , or nerve cells each express a different set of genes. Epigenetics is the mechanism of how cells control such gene activity without changing the DNA sequence.

RAADfest 2024: An Early Preview

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RAADfest is the largest and most immersive event in the world focused on super-longevity for a general audience. Bringing together cutting-edge science, inspiration, entertainment and fun, RAADfest is more than just a conference – it’s a celebration of life. From brain longevity and sexual health, to senolytics, personalized medicine and helping your pets live longer too, RAADfest provides the information and inspiration to enable people to take charge of their longevity.

For more info, visit: https://www.raadfest.com/

Produced by the Coalition for Radical Life Extension, RAADfest also includes RAADcity, the international product expo. RAADcity features leading brands sharing demos and deals on their longevity products and services with the people who want and need them the most.

When: Sept 5th to 8th, 2024

Exploring consciousness with ‘eureka’ moments

For generations, researchers have been pondering the question of how and where consciousness is formed in the brain. Professor Ekrem Dere from Ruhr University Bochum, Germany, proposes a new approach to researching conscious cognitive information processing. He advocates defining phases of conscious cognitive processes on the basis of behavioral observations and learning curves.

“Learning is often not a gradual process, but takes place in leaps and bounds; you could say that humans and experience sudden epiphanies every now and then,” he says. “It’s likely that these experiences are preceded by conscious processes.”

Dere outlines his new approach, which might apply to both humans and animals, in an article published in the journal Frontiers in Behavioral Neuroscience.

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