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Category: neuroscience – Page 186

Krembil Brain Institute researchers identify new model of Alzheimer’s as an autoimmune disease

(Toronto, Sept. 27, 2022) – Scientists at the Krembil Brain Institute, part of the University Health Network, have proposed a new mechanistic model (AD2) for Alzheimer’s, looking at it not as a brain disease, but as a chronic autoimmune condition that attacks the brain.

This novel research is published today, in Alzheimer’s & Dementia.

“We don’t think of Alzheimer’s as fundamentally a disease of the brain. We think of it as a disease of the immune system within the brain,” says Dr. Donald Weaver, co-Director of the Krembil Brain Institute and author of the paper.

Alzheimer’s disease, the most common form of dementia, impacts more than 50 million people around the world, with a new person being diagnosed every three seconds. Yet, despite more than 200 clinical trials in the past 30 years, there are no disease modifying therapeutics to prevent, halt or treat Alzheimer’s.

(Circa 2022 the immune function and immune molecules have been focused on recently making immunotherapy targets interesting consdering they can help remove plaques)

Elon Musk’s Neuralink microchip implanted into patient’s brain at University of Miami

Dr. Jagid and his team executed the implant on RJ just months ago.

“This device is completely invisible, you know, to anybody else that interacts with somebody who has it implanted. The other thing that makes it very unique is how it’s been miniaturized. It’s a very small device,” Dr. Jagid said.

During Neuralink’s summer update on the trial, they showed the moment one participant was able to move a cursor with his thoughts.

The Anatomy of Collective Mind Control

Unlock All The Power of Your Mind:
https://thehiddenlibrary.org/

Behind the illusion of free choice and authentic thought lies an invisible architecture shaping the collective mind. In this video, we dive deep into the anatomy of large-scale mind control. This is a form of psychic engineering that goes far beyond propaganda and mainstream media. We expose the hidden mechanisms that domesticate consciousness and manufacture consensus, from symbolic archetypes to technologies of mass emotional manipulation.

You are alive, but not awake. You walk, speak, decide, yet everything in you is mechanical. An automaton moved by impulses you do not understand. The collective mind is the machine and you are just a part of it. This video is not entertainment. It is a call to inner work. If there is still a living spark within you, it will feel this. And maybe, for the first time, you will realize you have never been free.

Integration of 3D-printed cerebral cortical tissue into an ex vivo lesioned brain slice

Brain injuries can result in significant damage to the cerebral cortex, and restoring the cellular architecture of the tissue remains challenging. Here, the authors use a droplet printing technique to fabricate a simplified human cerebral cortical column and demonstrate its functionality and potential for future personalized therapy approaches.

Atomic swap in morphine core structure leads to safer, non-rewarding opioid alternative

One of the greatest revolutions in the field of pain medication was the isolation of morphine from the opium poppy in the 19th century. Morphine molecules act as painkillers by attaching themselves to the µ-opioid receptor (MOR) in the central nervous system and blocking the brain from sending pain signals to the rest of the body. This potent opioid analgesic also has side effects such as constipation, respiratory depression, and even serious addiction problems.

A new study published in the Proceedings of the National Academy of Sciences has found that a single heavy atom replacement in the morphine core structure can transform its pharmacological behavior, resulting in reduced and no evidence of reward behavior—a key component of addiction tendencies—even at high doses.

Based on the insight that core-atom changes to the drug molecule may exhibit biological effects distinct from the parent compound, the researchers developed a 15-step total synthesis of a morphine derivative where an oxygen atom in the E-ring is replaced with a methylene (CH2) group and called the new derivative carbamorphine.

Childhood trauma shapes adult stress appraisal and mental health outcomes, research reveals

University of Leeds psychologists report that stress appraisal and perceived stress act as key conduits linking childhood trauma to adult depression, anxiety, defeat, and entrapment.

Childhood trauma affects nearly one third of young people in the United Kingdom. Early experiences of abuse or neglect have been associated with depression, anxiety, , and substance use later in life.

Exposure to multiple types of trauma has been linked to higher rates of suicidal thoughts and . Females who experience childhood sexual abuse can face substantially elevated risks of attempting suicide compared to peers without such histories.

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