Lifeboat Foundation

Incredible though it may seem, a wriggly roundworm with no eyes, no spine, and no brain to speak of may still possess the most basic of animal emotions.

In recent research, the nematode, Caenorhabditis elegans, has shown a persistent negative reaction when given a quick electric zap. For many minutes after receiving the short and sharp shock, this species continued to ‘flee’ at high speeds in the laboratory.

Researchers from Nagoya City University in Japan and Northeastern University in the US say that the long-lasting response, which looks like the worm ‘running’ away, is indicative of a fear-like brain state.

The veteran US philosopher renowned for his theories of consciousness is an intriguing figure but too prone to ‘professorial preening’.

Repost, but if you know someone’s dealing with such, the information can help you and them. The suppressing of it can not help anyone.

Alzheimer’s disease varies widely in its age of onset, presentation, and severity. Recently, the SORL1 gene has received increased attention since variations in this gene have been associated with both early-and late-onset Alzheimer’s. However, little is known about how damage to SORL1 leads to disease.

Using stem cells from patients with Alzheimer’s, investigators from Harvard-affiliated Brigham and Women’s Hospital found that loss of normal SORL1 function leads to a reduction in two key proteins known to be involved in Alzheimer’s and which play an essential role in the neurons of healthy individuals.

Continue reading “‘Molecular road’ to Alzheimer’s leads to new treatment strategy” »

Tiny, brainless jellyfish just did something that on the surface may seem impossible: the adorable creatures showed evidence of learning.

Even with just 1,000 neurons active at a time and no central brain, Caribbean box jellyfish (Tripedalia cystophora) can learn from experience, researchers argue in a new paper published September 22 in the journal Current Biology. The results aren’t surprising, say several scientists not involved in the project, but are a reminder for people to think more broadly about learning.

“If you’re an animal and have to navigate the world, you have to learn cues and consequences. Otherwise you’re dead, and you can’t reproduce,” says Christie Sahley, a… More.

Continue reading “These Adorable Jellyfish Show Learning Doesn’t Even Require a Brain” »

Hey and we are back … this is Max Flow and we will get to know more about the information limitations of psyche.

Neurons are living cells with a metabolism; they need oxygen and glucose to survive, and when they’ve been working hard, we experience fatigue. Every status update we read on social media, every tweet or text message we get from a friend, is competing for resources in our brains.

Continue reading “Mental perception bandwidth — FlowCode Lesson #16 / Flow state training” »

Coverage of the risks and benefits of AI have paid scant attention to how chatbots might affect public health at a time when depression, suicide, anxiety, and mental illness are epidemic in the United States. But mental health experts and the healthcare industry view AI mostly as a promising tool, rather than a potential threat to mental health.

Summary: Scientists made a novel discovery using zebrafish with a genetic mutation. These ‘deep-blind’ fish lack connections between the retina and brain yet retain functional brain circuits.

Remarkably, despite their inability to see, direct brain stimulation through optogenetics triggers normal visual behavior. This suggests that much of the zebrafish brain’s wiring is innate and doesn’t rely heavily on visual experience.

Hospital nurseries routinely place soft bands around the tiny wrists of newborns that hold important identifying information such as name, sex, mother, and birth date. Researchers at Rockefeller University are taking the same approach with newborn brain cells—but these neonates will keep their ID tags for life, so that scientists can track how they grow and mature, as a means for better understanding the brain’s aging process.

As described in a new paper in Cell, the new method developed by Rockefeller geneticist Junyue Cao and his colleagues is called TrackerSci (pronounced “sky”). This low-cost, high-throughput approach has already revealed that while newborn cells continue to be produced through life, the kinds of cells being produced greatly vary in different ages. This groundbreaking work, led by co-first authors Ziyu Lu and Melissa Zhang from Cao’s lab, promises to influence not only the study of the brain but also broader aspects of aging and disease across the human body.

“The cell is the basic functional unit of our body, so changes to the cell essentially underlie virtually every disease and the aging process,” says Cao, head of the Laboratory of Single-Cell Genomics and Population Dynamics. “If we can systematically characterize the different cells and their dynamics using this novel technique, we may get a panoramic view of the mechanisms of many diseases and the enigma of aging.”

Early-life stress (ELS) is one of the strongest lifetime risk factors for depression, anxiety, suicide, and other psychiatric disorders, particularly after facing additional stressful events later in life. Human and animal studies demonstrate that ELS sensitizes individuals to subsequent stress. However, the neurobiological basis of such stress sensitization remains largely unexplored. We hypothesized that ELS-induced stress sensitization would be detectable at the level of neuronal ensembles, such that cells activated by ELS would be more reactive to adult stress. To test this, we leveraged transgenic mice to genetically tag, track, and manipulate experience-activated neurons. We found that in both male and female mice, ELS-activated neurons within the nucleus accumbens (NAc), and to a lesser extent the medial prefrontal cortex, were preferentially reactivated by adult stress. To test whether reactivation of ELS-activated ensembles in the NAc contributes to stress hypersensitivity, we expressed hM4Dis receptor in control or ELS-activated neurons of pups and chemogenetically inhibited their activity during experience of adult stress. Inhibition of ELS-activated NAc neurons, but not control-tagged neurons, ameliorated social avoidance behavior following chronic social defeat stress in males. These data provide evidence that ELS-induced stress hypersensitivity is encoded at the level of corticolimbic neuronal ensembles.

SIGNIFICANCE STATEMENT Early-life stress enhances sensitivity to stress later in life, yet the mechanisms of such stress sensitization are largely unknown. Here, we show that neuronal ensembles in corticolimbic brain regions remain hypersensitive to stress across the life span, and quieting these ensembles during experience of adult stress rescues stress hypersensitivity.