What if the next global health crisis is a mental health pandemic? It is here now.
According to Gallup, anger, stress, worry and sadness have been on the rise globally for the past decade — long before the COVID-19 pandemic — and all reached record highs in 2020.
People die from COVID-19 — they also die from depression and anxiety disorders. The U.S. has seen spikes in deaths from suicide and “deaths of despair.”
Deaths of despair — a new designation made prominent by Princeton economists Anne Case and Nobel laureate Sir Angus Deaton in their book of the same name — are suicides and deaths caused by fatal behaviors such as drug overdoses and liver failure from chronic alcohol consumption. They have particularly harmed working-class males in the American heartland and increased dramatically since the mid-1990s, from about 65,000 in 1995 to 158,000 in 2018.
Think of deaths of despair as suicide in slow motion.
Rapid advances in large-scale connectomics are beginning to spotlight the importance of individual variations in the neural circuitry. They also highlight the limitations of “wiring diagrams” alone.
Theoretical physicist Sean Carroll joins us to discuss whether it make sense to think of consciousness as an emergent phenomenon, and whether contemporary physics points in this direction.
Science isn’t all lab coats and test tubes. Beautiful visuals can engage people—especially students—and inspire them to learn about science more broadly.
Scientists have often invited the public to see what they see, using everything from engraved woodblocks to electron microscopes to explore the complexity of the scientific enterprise and the beauty of life. Sharing these visions through illustrations, photography, and videos has allowed laypeople to explore a range of discoveries, from new bird species to the inner workings of the human cell.
As a neuroscience and bioscience researcher, I know that scientists are sometimes pigeonholed as white lab coats obsessed with charts and graphs. What that stereotype misses is their passion for science as a mode of discovery. That’s why scientists frequently turn to awe-inducing visualizations as a way to explain the unexplainable.
They were able to observe how well the cells in a tiny type of see-through jellyfish operate collectively, to produce complicated independent motions, such as capturing and consuming food source. This is all thanks to ingenious molecular manipulation.
Boyden’s award-winning research has led to tools that can activate or silence neurons with light, enabling the causal assessment of how specific neurons contribute to normal and pathological brain functions.
Ed Boyden is the founder and principal investigator of the Synthetic Neurobiology Group at Massachusetts Institute of Technology (MIT). The group develops tools for controlling and observing the dynamic circuits of the brain, and uses these neurotechnologies to understand how cognition and emotion arise from brain network operation, as well as to enable systematic repair of intractable brain disorders such as epilepsy, Parkinson’s disease, post-traumatic stress disorder, and chronic pain.
Many disorders of the brain currently are treated with drugs or electrical stimulation. Nearly a quarter of million people have implanted electrical probes in their brains for such stimulation. The problem with this approach is that it targets large areas of the brain instead of the discrete cells or location that cause the disorder. Boyden works on implementing light-stimulated processes in the brain to address these disorders at the cellular level. The method utilizes adeno-associated viruses (AAV) to create light-sensitive centers in the brain which can then be stimulated by light pulses. Very small optical waveguides (fibers) can then be introduced in the brain to stimulate these sites.
Boyden was named to the “Top 35 Innovators Under the Age of 35″ by Technology Review and to the “Top 20 Brains Under Age 40″ by Discover, and has received the NIH Director’s New Innovator Award, the Society for Neuroscience Research Award for Innovation in Neuroscience, and the Paul Allen Distinguished Investigator Award, as well as numerous other recognitions. In early 2011, he was an invited speaker at the renowned TED conference, sharing the bill with a high-powered lineup that included presenters as diverse as Bill Gates and choreographer Julie Taymor.
He has contributed numerous articles to SPIE Proceedings, and was an invited speaker at the Biomedical Optics Hot Topics Session at SPIE Photonics West 2011.
Nick talks to Stanford psychiatrist and neuroscientist Dr. Karl Deisseroth. They discuss a range of topics about the brain, including autism, depression, bipolar disorder, dissociation, and more. They also talk about optogenetics, a technique Karl co-developed which uses light to control specific neurons in the brain, allowing neuroscientists to turn circuits in the brain on and off to reveal how the brain generates perception, emotion, and behavior. They also talk about Karls’ new book, “Projections: A Story of Human Emotion.”
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at Leafly, the world’s largest cannabis information resource. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
Let me back up a moment. I recently concurred with megapundit Steven Pinker that over the last two centuries we have achieved material, moral and intellectual progress, which should give us hope that we can achieve still more. I expected, and have gotten, pushback. Pessimists argue that our progress will prove to be ephemeral; that we will inevitably succumb to our own nastiness and stupidity and destroy ourselves.
Maybe, maybe not. Just for the sake of argument, let’s say that within the next century or two we solve our biggest problems, including tyranny, injustice, poverty, pandemics, climate change and war. Let’s say we create a world in which we can do pretty much anything we choose. Many will pursue pleasure, finding ever more exciting ways to enjoy themselves. Others may seek spiritual enlightenment or devote themselves to artistic expression.
No matter what our descendants choose to do, some will surely keep investigating the universe and everything in it, including us. How long can the quest for knowledge continue? Not long, I argued 25 years ago this month in The End of Science, which contends that particle physics, cosmology, neuroscience and other fields are bumping into fundamental limits. I still think I’m right, but I could be wrong. Below I describe the views of three physicists—Freeman Dyson, Roger Penrose and David Deutsch—who hold that knowledge seeking can continue for a long, long time, and possibly forever, even in the face of the heat death of the universe.
