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My infomercial of the day — “just ad water and Ta-dah, you have a vaccine!”

http://thejerseytomatopress.com/stories/To-produce-biopharma…water,1851


Researchers at MIT and other institutions have created tiny freeze-dried pellets that include all of the molecular machinery needed to translate DNA into proteins, which could form the basis for on-demand production of drugs and vaccines. Image: Christine Daniloff/MIT. Antimicrobial peptide illustration by Ymahn/Wikimedia Commons.

Anne Trafton | MIT

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Luv this.


Tufts University engineers have created a new format of solids made from silk protein that can be preprogrammed with biological, chemical, or optical functions, such as mechanical components that change color with strain, deliver drugs, or respond to light, according to a paper published online this week in Proceedings of the National Academy of Sciences (PNAS).

Using a water-based fabrication method based on protein self-assembly, the researchers generated three-dimensional bulk materials out of silk fibroin, the protein that gives silk its durability. Then they manipulated the bulk materials with water-soluble molecules to create multiple solid forms, from the nano- to the micro-scale, that have embedded, pre-designed functions.

For example, the researchers created a surgical pin that changes color as it nears its mechanical limits and is about to fail, functional screws that can be heated on demand in response to infrared light, and a biocompatible component that enables the sustained release of bioactive agents, such as enzymes.

PanARMENIAN.Net — In the future, getting customized cancer treatments might just be a matter of injecting virtually invisible discs into your body, Engadget said.

University of Michigan scientists have had early success testing 10nm “nanodiscs” that teach your body to kill cancer cells. Each disc is full of neoantigens, or tumor-specific mutations, that tell your immune system’s T-cells to recognize those neoantigens and kill them. When you pair them up with immune checkpoint inhibitors (which boost the T-cells’ responses), they can not only wipe out existing tumors, but prevent them from reemerging later.

This testing has been limited to mice so far, but it’s promising. The nanodiscs took 10 days to eliminate tumors, and they shut down identical tumors when they were reinserted 70 days later. For the researchers, the big challenge right now is scaling the tests to see if they still hold up with larger animals. If the approach proves successful with humans, the days of generic cancer solutions might be limited — so long as doctors could get a sample of your cancer, they’d stand a realistic chance of eliminating the disease, Engadget said.

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What’s next? Nanocavities in a diamond for small devices.


Researchers have developed a new type of light-enhancing optical cavity that is only 200 nanometers tall and 100 nanometers across. Their new nanoscale system represents a step toward brighter single-photon sources, which could help propel quantum-based encryption techniques under development.

Quantum encryption techniques, which are seen as likely to be central to future data encryption methods, use individual photons as an extremely secure way to encode data. A limitation of these techniques has been the ability to emit photons at high rates. “One of the most important figures of merit for single-photon sources is brightness — or collected photons per second — because the brighter it is, the more data you can transmit securely with quantum encryption,” said Yousif Kelaita of Stanford University.

In the journal Optical Materials Express, from The Optical Society (OSA), Kelaita and his colleagues show that their new nanocavity significantly increased the emission brightness of quantum dots — nanometer-scale semiconductor particles that can emit single photons.

Happy Holidays; happy end of the year, happy launch of next year, happy snow days, happy hot chocolate day, etc. Nonetheless, my gift to you this year is a Nanoscale Snowman.


Would a jewel-encrusted snowman make the perfect Christmas present? At only 5 nanometres in size, the price might be lower than you think. And it’s functional too, catalysing the splitting of water to make green hydrogen for fuel cells.

The nanoparticle, as imaged with the aberration-corrected scanning transmission electron microscopes, features eyes, nose and mouth of precious-metal platinum clusters embedded in a titanium dioxide face. Each platinum cluster typically contains 30 platinum atoms; within the whole nanoparticle there are approximately 1680 and 180 platinum atoms.

The nano-snowman formed spontaneously from a self-assembled platinum-titanium nanoparticle which was oxidised in air, drawing the titanium atoms out to the surface. The self-assembly occurred in a gas phase, cluster beam condensation source, before size-selection with a spectrometer and deposition onto a carbon surface for oxidation and then imaging. The mass of the snowman was 120,000 atomic mass units. Compared with a more conventional pure platinum catalyst particle, the inclusion of the titanium atoms offers two potential benefits: dilution of how much precious platinum is needed to perform the catalysis, and protection of the cores against sintering (i.e. aggregation of the nanoparticles). The shell is porous enough to allow hydrogen through and the particles are functional in the evolution reaction.

Researchers have developed a new type of light-enhancing optical cavity that is only 200 nanometers tall and 100 nanometers across. Their new nanoscale system represents a step toward brighter single-photon sources, which could help propel quantum-based encryption and a truly secure and future-proofed network.

Quantum encryption techniques, which are seen as likely to be central to future data encryption methods, use individual as an extremely secure way to encode data. A limitation of these techniques has been the ability to emit photons at high rates. “One of the most important figures of merit for single-photon sources is brightness—or collected photons per second—because the brighter it is, the more data you can transmit securely with quantum encryption,” said Yousif Kelaita, Nanoscale and Quantum Photonics Lab, Stanford University, California.

In the journal Optical Materials Express, Kelaita and his colleagues show that their new nanocavity significantly increased the emission brightness of quantum dots—nanometer-scale semiconductor particles that can emit single photons.

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Scientists at The Rockefeller University have created the most detailed three-dimensional images to date of an important step in the process by which cells make the nano-machines responsible for producing all-important protein. The results, described December 15 in Science, are prompting the researchers to re-evaluate how they envision this early phase in the construction of ribosomes.

“The structure they determined, shown above, belongs to a particle formally called the “small subunit processome.” Before this particle can fulfill its destiny to become the smaller half of a complete ribosome, the RNA within it needs to be folded, tweaked, and cut.

“Initially, we thought of the small subunit processome as a product on an assembly line, with molecular workers arriving from outside, much like the robots that would put together a car. But that analogy no longer appears apt,” says senior author Sebastian Klinge, head of the Laboratory of Protein and Nucleic Acid Chemistry.

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From laptops to cellphones, technology advances through the ever-increasing speed at which electric charges are directed through circuits. Similarly, speeding up control over quantum states in atomic and nanoscale systems could lead to leaps for the emerging field of quantum technology.

An international collaboration between physicists at the University of Chicago, Argonne National Laboratory, McGill University, and the University of Konstanz recently demonstrated a new framework for faster control of a quantum bit. First published online Nov. 28, 2016, in Nature Physics, their experiments on a single electron in a diamond chip could create quantum devices that are less prone to errors when operated at high speeds.

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