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Category: nanotechnology – Page 198

This Nano-Robot Built Out of DNA Will Study Cell Processes Closely

The researchers wanted to create robots that could pick up and sort molecules within a designated space. This makes it possible for DNA molecules to serve as the building blocks for 3D nanostructures that self-assemble in a predetermined shape. Tiny DNA-based robots and other nanodevices will deliver medicine inside our bodies, detect the presence of deadly pathogens, and help manufacture increasingly smaller electronics.

This enabled the researchers to design a nano-robot composed of three DNA origami structures. To help it maneuver within the designated space, the robot had a “leg” with a pair of feet. An “arm” with a “hand” allowed it to carry cargo, and a third component was added to tell the hand when a specific drop-off point had been reached so it would know to release the cargo. It allows researchers to carry out the entire design truly in 3D. Earlier design tools only allowed creation in 2D, forcing researchers to map their creations into 3D.

The software helps researchers design ways to take tiny strands of DNA and combine them into complex structures with parts like rotors and hinges that can move and complete a variety of tasks, including drug delivery. The robot will also enable researchers to more precisely determine important signaling pathways for a variety of biological and pathological processes that are stimulated at the cellular level during the application of force.

Graphene oxide membranes reveal unusual behaviour of water at the nanoscale

Do more pores in a sieve allow more liquid to flow through it? As material scientists have uncovered, this seemingly simple question may have an unexpected answer at the nanoscale—and it could have important implications in the development of water filtration, energy storage and hydrogen production.

Researchers from UNSW Sydney, University of Duisburg-Essen (Germany), GANIL (France) and Toyota Technological Institute (Japan) experimenting with Graphene Oxide (GO) membranes have discovered the opposite can occur at the nanoscopic level. The research, published in Nano Letters, shows the chemical environment of the sieve and the of the liquid play a surprisingly important role in permeability.

The researchers observed that a density of pores doesn’t necessarily lead to higher permeability—in other words, having more tiny holes doesn’t always allow water to flow through at the nanoscale. The study, supported by the European Union and Humboldt Research Foundation funding, shines new light on the mechanisms that govern water flow through GO membranes.

Building decarbonization: How electric heat pumps could help reduce emissions today and going forward

The electrification of heating systems could play a significant role in building decarbonization. Heat pumps are emerging as a solution.

Iranian scientists have demonstrated a multi-layer silicon nanoparticle (SNP) solar cell based on nanoparticles that are densely stacked inside a dielectric medium. They considered different SNP structures and configurations to tailor these particles as a p–n junction cell.

Ultra-thin silicon nanoparticle solar cell with 11% efficiency

“This is because SNPs are assumed to be the main absorber in the cell. Thus, any distance between them reduces the absorption of incident photons,” the group said.

They considered different SNP structures and configurations to tailor these particles as a p–n junction cell. They said this kind of cell could achieve a theoretical efficiency of around 11%.

Researchers create flow-driven rotors at the nanoscale

Researchers from TU Delft have constructed the smallest flow-driven motors in the world. Inspired by iconic Dutch windmills and biological motor proteins, they created a self-configuring flow-driven rotor from DNA that converts energy from an electrical or salt gradient into useful mechanical work. The results open new perspectives for engineering active robotics at the nanoscale.

The article is now published in Nature Physics (“Sustained unidirectional rotation of a self-organized DNA rotor on a nanopore”).

Rotary motors have been the powerhouses of human societies for millennia: from the windmills and waterwheels across the Netherlands and the world to today’s most advanced off-shore wind turbines that drive our green-energy future.

A ‘nano-robot’ built entirely from DNA to explore cell processes

Constructing a tiny robot from DNA and using it to study cell processes invisible to the naked eye… You would be forgiven for thinking it is science fiction, but it is in fact the subject of serious research by scientists from Inserm, CNRS and Université de Montpellier at the Structural Biology Center in Montpellier. This highly innovative “nano-robot” should enable closer study of the mechanical forces applied at microscopic levels, which are crucial for many biological and pathological processes. It is described in a new study published in Nature Communications.

Our are subject to exerted on a microscopic scale, triggering biological signals essential to many involved in the normal functioning of our body or in the development of diseases.

For example, the feeling of touch is partly conditional on the application of mechanical forces on specific cell receptors (the discovery of which was this year rewarded by the Nobel Prize in Physiology or Medicine). In addition to touch, these receptors that are sensitive to mechanical forces (known as mechanoreceptors) enable the regulation of other key biological processes such as blood vessel constriction, pain perception, breathing or even the detection of sound waves in the ear, etc.

Researchers 3D print high-performance nanostructured alloy that’s both ultrastrong and ductile

Researchers at the University of Massachusetts Amherst and the Georgia Institute of Technology have 3D printed a dual-phase, nanostructured high-entropy alloy that exceeds the strength and ductility of other state-of-the-art additively manufactured materials, which could lead to higher-performance components for applications in aerospace, medicine, energy and transportation.

The work, led by Wen Chen, assistant professor of mechanical and industrial engineering at UMass, and Ting Zhu, professor of mechanical engineering at Georgia Tech, is published by the journal Nature (“Strong yet ductile nanolamellar high-entropy alloys by additive manufacturing”).

Wen Chen, assistant professor of mechanical and industrial engineering at UMass Amherst, stands in front of images of 3D printed high-entropy alloy components (heatsink fan and octect lattice, left) and a cross-sectional electron backscatter diffraction inverse-pole figure map demonstrating a randomly oriented nanolamella microstructure (right). (Image: UMass Amherst)

High Cholesterol May Be a Thing of the Past Using Gene Therapy

New gene therapy could end high cholesterol responsible for strokes and heart attacks.

The therapy is a one-and-done treatment unlike being on statins or taking monoclonal antibodies. It will make a permanent change to liver cells and stop them from producing the PCSK9 protein. The edits will pass on to the next generation of cells when they divide. That means that even if the therapy is initially expensive, the lifetime cost should prove to be comparable if not lower than current alternatives.

The therapy is delivered to the liver cells in lipid nanoparticles, the same technology being used by mRNA Covid-19 vaccines. The pandemic has created manufacturing capacity for this type of therapeutic delivery which is helping to lower costs.

A successful clinical trial doesn’t lead right away to adoption throughout the medical profession. It is likely there will be many more trials, and a number of years before Verve has enough data to convince regulators to approve the treatment for run-of-the-mill high cholesterol. If it turns out to become the new treatment standard, however, it will be one of the most transformational innovations in human healthcare to be seen in decades.

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