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It sounds like cryonics is working, at least for microbes. But could any humans now alive have resistance to ancient organisms?

Rational Review carried a link to this story:

http://www.foxnews.com/story/0,2933,526460,00.html

“After more than 120,000 years trapped beneath a block of ice in Greenland, a tiny microbe has awoken. … The new bacteria species was found nearly 2 miles (3 km) beneath a Greenland glacier, where temperatures can dip well below freezing, pressure soars, and food and oxygen are scarce. ‘We don’t know what state they were in,’ said study team member Jean Brenchley of Pennsylvania State University. ‘They could’ve been dormant, or they could’ve been slowly metabolizing, but we don’t know for sure.’”

It is yet another interesting possibility against which humans should prepare to protect ourselves. Where is our Lifeboat?

The projected size of Barack Obama’s “stimulus package” is heading north, from hundreds of billions of dollars into the trillions. And the Obama program comes, of course, on top of the various Bush administration bailouts and commitments, estimated to run as high as $8.5 trillion.

Will this money be put to good use? That’s an important question for the new President, and an even more important question for America. The metric for all government spending ultimately comes down to a single query: What did you get for it?

If such spending was worth it, that’s great. If the country gets victory in war, or victory over economic catastrophe, well, obviously, it was worthwhile. The national interest should never be sacrificed on the altar of a balanced budget.

So let’s hope we get the most value possible for all that money–and all that red ink. Let’s hope we get a more prosperous nation and a cleaner earth. Let’s also hope we get a more secure population and a clear, strategic margin of safety for the United States. Yet how do we do all that?

There’s only one best way: Put space exploration at the center of the new stimulus package. That is, make space the spearhead rationale for the myriad technologies that will provide us with jobs, wealth, and vital knowhow in the future. By boldly going where no (hu)man has gone before, we will change life here on earth for the better.

To put it mildly, space was not high on the national agenda during 2008. But space and rocketry, broadly defined, are as important as ever. As Cold War arms-control theology fades, the practical value of missile defense–against superpowers, also against rogue states, such as Iran, and high-tech terrorist groups, such as Hezbollah and Hamas–becomes increasingly obvious. Clearly Obama agrees; it’s the new President, after all, who will be keeping pro-missile defense Robert Gates on the job at the Pentagon.

The bipartisan reality is that if missile offense is on the rise, then missile defense is surely a good idea. That’s why increasing funding for missile defense engages the attention of leading military powers around the world. And more signs appear, too, that the new administration is in that same strategic defense groove. A January 2 story from Bloomberg News, headlined “Obama Moves to Counter China With Pentagon-NASA Link,” points the way. As reported by Demian McLean, the incoming Obama administration is looking to better coordinate DOD and NASA; that only makes sense: After all, the Pentagon’s space expenditures, $22 billion in fiscal year 2008, are almost a third more than NASA’s. So it’s logical, as well as economical, to streamline the national space effort.

That’s good news, but Obama has the opportunity to do more. Much more.

Throughout history, exploration has been a powerful strategic tool. Both Spain and Portugal turned themselves into superpowers in the 15th and 16th century through overseas expansion. By contrast, China, which at the time had a technological edge over the Iberian states, chose not to explore and was put on the defensive. Ultimately, as we all know, China’s retrograde policies pushed the Middle Kingdom into a half-millennium-long tailspin.

Further, we might consider the enormous advantages that England reaped by colonizing a large portion of the world. Not only did Britain’s empire generate wealth for the homeland, albeit often cruelly, but it also inspired technological development at home. And in the world wars of the 20th century, Britain’s colonies, past and present, gave the mother country the “strategic depth” it needed for victory.

For their part, the Chinese seem to have absorbed these geostrategic lessons. They are determined now to be big players in space, as a matter of national grand strategy, independent of economic cycles. In 2003, the People’s Republic of China powered its first man into space, becoming only the third country to do so. And then, more ominously, in 2007, China shot down one of their own weather satellites, just to prove that they had robust satellite-killing capacity.

Thus the US and all the other space powers are on notice: In any possible war, the Chinese have the capacity to “blind” our satellites. And now they plan to put a man on the moon in the next decade. “The moon landing is an extremely challenging and sophisticated task,” declared Wang Zhaoyao, a spokesman for China’s space program, in September, “and it is also a strategically important technological field.”

India, the other emerging Asian superpower, is paying close attention to its rival across the Himalayas. Back in June, The Washington Times ran this thought-provoking headline: “China, India hasten arms race in space/U.S. dominance challenged.” According to the Times report, India, possessor of an extensive civilian satellite program, means to keep up with emerging space threats from China, by any means necessary. Army Chief of Staff Gen. Deepak Kapoor said that his country must “optimize space applications for military purposes,” adding, “the Chinese space program is expanding at an exponentially rapid pace in both offensive and defensive content.” In other words, India, like every other country, must compete–because the dangerous competition is there, like it or not.

India and China have fought wars in the past; they obviously see “milspace” as another potential theater of operations. And of course, Japan, Russia, Brazil, and the European Union all have their own space programs.

Space exploration, despite all the bonhomie about scientific and economic benefit for the common good, has always been driven by strategic competition. Beyond mere macho “bragging rights” about being first, countries have understood that controlling the high ground, or the high frontier, is a vital military imperative. So we, as a nation, might further consider the value of space surveillance and missile defense. It’s hard to imagine any permanent peace deal in the Middle East, for example, that does not include, as an additional safeguard, a significant commitment to missile and rocket defense, overseen by impervious space satellites. So if the U.S. and Israel, for example, aren’t there yet, well, they need to get there.

Americans, who have often hoped that space would be a demilitarized preserve for peaceful cooperation, need to understand that space, populated by humans and their machines, will be no different from earth, populated by humans and their machines. That is, every virtue, and every evil, that is evident down here will also be evident up there. If there have been, and will continue to be, arms races on earth, then there will be arms races in space. As we have seen, other countries are moving into space in a big way–and they will continue to do so, whether or not the U.S. participates.

Meanwhile, in the nearer term, if the Bush administration’s “forward strategy of freedom”–the neoconservative idea that we would make America safe by transforming the rest of the world–is no longer an operative policy, then we will, inevitably, fall back on “defense” as the key idea for making America safe.

But in the short run, of course, the dominant issue is the economy. Aside from the sometimes inconvenient reality that national defense must always come first, the historical record shows that high-tech space work is good for the economy; the list of spinoffs from NASA, spanning the last half-century, is long and lucrative.

Moreover, a great way to guarantee that the bailout/stimulus money is well spent is to link it to a specific goal–a goal which will in turn impose discipline on the spenders. During the New Deal, for example, there were many accusations of malfeasance against FDR’s “alphabet soup” of agencies, and yet the tangible reality, in the 30s, was that things were actually getting done. Jobs were created, and, just as more important, enduring projects were being built; from post offices to Hoover Dam to the Tennessee Valley Authority, America was transformed.

Even into the 50s and 60s, the federal government was spending money on ambitious and successful projects. The space program was one, but so was the interstate highway program, as well as that new government startup, ARPANET.

Indeed, it could be argued that one reason the federal government has grown less competent and more flabby over the last 30 years is the relative lack of “hard” Hamiltonian programs–that is, nuts and bolts, cement and circuitry–to provide a sense of bottom-line rigor to the spending process.

And so, for example, if America were to succeed in building a space elevator–in its essence a 22,000-mile cable, operating like a pulley, dangling down from a stationary satellite, a concept first put forth in the late 19th century–that would be a major driver for economic growth. Japan has plans for just such a space elevator; aren’t we getting a little tired of losing high-tech economic competitions to the Japanese?

So a robust space program would not only help protect America; it would also strengthen our technological economy.

But there’s more. In the long run, space spending would be good for the environment. Here’s why:

History, as well as common sense, tells us that the overall environmental footprint of the human race rises alongside wealth. That’s why, for example, the average American produces five times as much carbon dioxide per year as the average person dwelling anywhere else on earth. Even homeless Americans, according to an MIT study–and even the most scrupulously green Americans–produce twice as much CO2, per person, as the rest of the world. Around the planet, per capita carbon dioxide emissions closely track per capita income.

A holistic understanding of homo sapiens in his environment will acknowledge the stubbornly acquisitive and accretive reality of human nature. And so a truly enlightened environmental policy will acknowledge another blunt reality: that if the carrying capacity of the earth is finite, then it makes sense, ultimately, to move some of the population of the earth elsewhere–into the infinity of space.

The ZPG and NPG advocates have their own ideas, of course, but they don’t seem to be popular in America, let alone the world. But in the no-limits infinity of space, there is plenty of room for diversity and political experimentation in the final frontier, just as there were multiple opportunities in centuries past in the New World. The main variable is developing space-traveling capacity to get up there–to the moon, Mars, and beyond–to see what’s possible.

Instead, the ultimately workable environmental plan–the ultimate vision for preserving the flora, the fauna, and the ice caps–is to move people, and their pollution, off this earth.

Indeed, space travel is surely the ultimate plan for the survival of our species, too. Eventually, through runaway WMD, or runaway pollution, or a stray asteroid, or some Murphy-esque piece of bad luck, we will learn that our dominion over this planet is fleeting. That’s when we will discover the grim true meaning of Fermi’s Paradox.

In various ways, humankind has always anticipated apocalypse. And so from Noah’s Ark to “Silent Running” to “Wall*E,” we have envisioned ways for us and all other creatures, great and small, to survive. The space program, stutteringly nascent as it might be, can be seen as a slow-groping understanding that lifeboat-style compartmentalization, on earth and in the heavens, is the key to species survival. It’s a Darwinian fitness test that we ought not to flunk.

Barack Obama, who has blazed so many trails in his life, can blaze still more, including a track to space, over the far horizon of the future. In so doing, he would be keeping faith with a figure that he in many ways resembles, John F. Kennedy. It was the 35th President who declared that not only would America go to the moon, but that we would lead the world into space.

As JFK put it so ringingly back in 1962:

The vows of this Nation can only be fulfilled if we in this Nation are first, and, therefore, we intend to be first. In short, our leadership in science and in industry, our hopes for peace and security, our obligations to ourselves as well as others, all require us to make this effort, to solve these mysteries, to solve them for the good of all men, and to become the world’s leading space-faring nation.

Today the 44th President must spend a lot of money to restore our prosperity, but he must spend it wisely. He must also keep America secure against encroaching threats, even as he must improve the environment in the face of a burgeoning global economy.

Accomplishing all these tasks is possible, but not easy. Yes, of course he will need new ideas, but he will also need familiar and proven ideas. One of the best is fostering and deploying profound new technology in pursuit of expansion and exploration.

The stars, one might hope, are aligning for just such a rendezvous with destiny.

Here I would like to suggest readers a quotation from my book “Structure of the global catastrophe” (http://www.scribd.com/doc/7529531/-) there I discuss problems of preventing catastrophes.

Refuges and bunkers

Different sort of a refuge and bunkers can increase chances of survival of the mankind in case of global catastrophe, however the situation with them is not simple. Separate independent refuges can exist for decades, but the more they are independent and long-time, the more efforts are necessary for their preparation in advance. Refuges should provide ability for the mankind to the further self-reproduction. Hence, they should contain not only enough of capable to reproduction people, but also a stock of technologies which will allow to survive and breed in territory which is planned to render habitable after an exit from the refuge. The more this territory will be polluted, the higher level of technologies is required for a reliable survival.
Very big bunker will appear capable to continue in itself development of technologies and after catastrophe. However in this case it will be vulnerable to the same risks, as all terrestrial civilisation — there can be internal terrorists, AI, nanorobots, leaks etc. If the bunker is not capable to continue itself development of technologies it, more likely, is doomed to degradation.
Further, the bunker can be or «civilizational», that is keep the majority of cultural and technological achievements of the civilisation, or “specific”, that is keep only human life. For “long” bunkers (which are prepared for long-term stay) the problem of formation and education of children and risks of degradation will rise. The bunker can or live for the account of the resources which have been saved up before catastrophe, or be engaged in own manufacture. In last case it will be simply underground civilisation on the infected planet.
The more a bunker is constructed on modern technologies and independent cultural and technically, the higher ammount of people should live there (but in the future it will be not so: the bunker on the basis of advanced nanotechnology can be even at all deserted, — only with the frozen human embryos). To provide simple reproduction by means of training to the basic human trades, thousand people are required. These people should be selected and be in the bunker before final catastrophe, and, it is desirable, on a constant basis. However it is improbable, that thousand intellectually and physically excellent people would want to sit in the bunker “just in case”. In this case they can be in the bunker in two or three changes and receive for it a salary. (Now in Russia begins experiment «Mars 500» in which 6 humans will be in completely independent — on water, to meal, air — for 500 days. Possibly, it is the best result which we now have. In the early nineties in the USA there was also a project «Biosphera-2» in which people should live two years on full self-maintenance under a dome in desert. The project has ended with partial failure as oxygen level in system began to fall because of unforeseen reproduction of microorganisms and insects.) As additional risk for bunkers it is necessary to note fact of psychology of the small groups closed in one premise widely known on the Antarctic expeditions — namely, the increase of animosities fraught with destructive actions, reducing survival rate.
The bunker can be either unique, or one of many. In the first case it is vulnerable to different catastrophes, and in the second is possible struggle between different bunkers for the resources which have remained outside. Or is possible war continuation if catastrophe has resulted from war.
The bunker, most likely, will be either underground, or in the sea, or in space. But the space bunker too can be underground of asteroids or the Moon. For the space bunker it will be more difficult to use the rests of resources on the Earth. The bunker can be completely isolated, or to allow “excursion” in the external hostile environment.
As model of the sea bunker can serve the nuclear submarine possessing high reserve, autonomy, manoeuvrability and stability to negative influences. Besides, it can easily be cooled at ocean (the problem of cooling of the underground closed bunkers is not simple), to extract from it water, oxygen and even food. Besides, already there are ready boats and technical decisions. The boat is capable to sustain shock and radiating influence. However the resource of independent swimming of modern submarines makes at the best 1 year, and in them there is no place for storage of stocks.
Modern space station ISS could support independently life of several humans within approximately year though there are problems of independent landing and adaptation. Not clearly, whether the certain dangerous agent, capable to get into all cracks on the Earth could dissipate for so short term.
There is a difference between gaso — and bio — refuges which can be on a surface, but are divided into many sections for maintenance of a mode of quarantine, and refuges which are intended as a shelter from in the slightest degree intelligent opponent (including other people who did not manage to get a place in a refuge). In case of biodanger island with rigid quarantine can be a refuge if illness is not transferred by air.
A bunker can possess different vulnerabilities. For example, in case of biological threat, is enough insignificant penetration to destroy it. Only hi-tech bunker can be the completely independent. Energy and oxygen are necessary to the bunker. The system on a nuclear reactor can give energy, but modern machines hardly can possess durability more than 30–50 years. The bunker cannot be universal — it should assume protection against the certain kinds of threats known in advance — radiating, biological etc.
The more reinforced is a bunker, the smaller number of bunkers can prepare mankind in advance, and it will be more difficult to hide such bunker. If after a certain catastrophe there was a limited number of the bunkers which site is known, the secondary nuclear war can terminate mankind through countable number of strikes in known places.
The larger is the bunker, the less amount of such bunkers is possible to construct. However any bunker is vulnerable to accidental destruction or contamination. Therefore the limited number of bunkers with certain probability of contamination unequivocally defines the maximum survival time of mankind. If bunkers are connected among themselves by trade and other material distribution, contamination between them is more probable. If bunkers are not connected, they will degrade faster. The more powerfully and more expensively is the bunker, the more difficult is to create it imperceptibly for the probable opponent and so it easeir becomes the goal for an attack. The more cheaply the bunker, the less it is durable.
Casual shelters — the people who have escaped in the underground, mines, submarines — are possible. They will suffer from absence of the central power and struggle for resources. The people, in case of exhaustion of resources in one bunker, can undertake the armed attempts to break in other next bunker. Also the people who have escaped casually (or under the threat of the comong catastrophe), can attack those who was locked in the bunker.
Bunkers will suffer from necessity of an exchange of heat, energy, water and air with an external world. The more independent is the bunker, the less time it can exist in full isolation. Bunkers being in the Earth will deeply suffer from an overheating. Any nuclear reactors and other complex machines will demand external cooling. Cooling by external water will unmask them, and it is impossible to have energy sources lost-free in the form of heat, while on depth of earth there are always high temperatures. Temperature growth, in process of deepening in the Earth, limits depth of possible bunkers. (The geothermal gradient on the average makes 30 degrees C/kilometers. It means, that bunkers on depth more than 1 kilometre are impossible — or demand huge cooling installations on a surface, as gold mines in the republic of South Africa. There can be deeper bunkers in ices of Antarctica.)
The more durable, more universal and more effective, should be a bunker, the earlier it is necessary to start to build it. But in this case it is difficult to foresee the future risks. For example, in 1930th years in Russia was constructed many anti-gase bombproof shelters which have appeared useless and vulnerable to bombardments by heavy demolition bombs.
Efficiency of the bunker which can create the civilisation, corresponds to a technological level of development of this civilisation. But it means that it possesses and corresponding means of destruction. So, especially powerful bunker is necessary. The more independently and more absolutely is the bunker (for example, equipped with AI, nanorobots and biotechnologies), the easier it can do without, eventually, people, having given rise to purely computer civilisation.
People from different bunkers will compete for that who first leaves on a surface and who, accordingly, will own it — therefore will develop the temptation for them to go out to still infected sites of the Earth.
There are possible automatic robotic bunkers: in them the frozen human embryos are stored in a certain artificial uterus and through hundreds or thousand years start to be grown up. (Technology of cryonics of embryos already exists, and works on an artificial uterus are forbidden for bioethics reasons, but basically such device is possible.) With embryos it is possible to send such installations in travel to other planets. However, if such bunkers are possible, the Earth hardly remains empty — most likely it will be populated with robots. Besides, if the human cub who has been brought up by wolves, considers itself as a wolf as whom human who has been brought up by robots will consider itself?
So, the idea about a survival in bunkers contains many reefs which reduce its utility and probability of success. It is necessary to build long-term bunkers for many years, but they can become outdated for this time as the situation will change and it is not known to what to prepare. Probably, that there is a number of powerful bunkers which have been constructed in days of cold war. A limit of modern technical possibilities the bunker of an order of a 30-year-old autonomy, however it would take long time for building — decade, and it will demand billions dollars of investments.
Independently there are information bunkers, which are intended to inform to the possible escaped descendants about our knowledge, technologies and achievements. For example, in Norway, on Spitsbergen have been created a stock of samples of seeds and grain with these purposes (Doomsday Vault). Variants with preservation of a genetic variety of people by means of the frozen sperm are possible. Digital carriers steady against long storage, for example, compact discs on which the text which can be read through a magnifier is etched are discussed and implemented by Long Now Foundation. This knowledge can be crucial for not repeating our errors.

November 14, 2008
Computer History Museum, Mountain View, CA

http://ieet.org/index.php/IEET/eventinfo/ieet20081114/

Organized by: Institute for Ethics and Emerging Technologies, the Center for Responsible Nanotechnology and the Lifeboat Foundation

A day-long seminar on threats to the future of humanity, natural and man-made, and the pro-active steps we can take to reduce these risks and build a more resilient civilization. Seminar participants are strongly encouraged to pre-order and review the Global Catastrophic Risks volume edited by Nick Bostrom and Milan Cirkovic, and contributed to by some of the faculty for this seminar.

This seminar will precede the futurist mega-gathering Convergence 08, November 15–16 at the same venue, which is co-sponsored by the IEET, Humanity Plus (World Transhumanist Association), the Singularity Institute for Artificial Intelligence, the Immortality Institute, the Foresight Institute, the Long Now Foundation, the Methuselah Foundation, the Millenium Project, Reason Foundation and the Accelerating Studies Foundation.

SEMINAR FACULTY

  • Nick Bostrom Ph.D., Director, Future of Humanity Institute, Oxford University
  • Jamais Cascio, research affiliate, Institute for the Future
  • James J. Hughes Ph.D., Exec. Director, Institute for Ethics and Emerging Technologies
  • Mike Treder, Executive Director, Center for Responsible Nanotechnology
  • Eliezer Yudkowsky, Research Associate. Singularity Institute for Artificial Intelligence
  • William Potter Ph.D., Director, James Martin Center for Nonproliferation Studies

REGISTRATION:
Before Nov 1: $100
After Nov 1 and at the door: $150

This is cross-posted from my blog. This milestone by SpaceX is directly relevant to programs by Lifeboat such as the AsteroidShield and SpaceHabitat, and possibly also (eventually) to Space-Based Solar Power.

SpaceX Falcon 1 Rocket Launch photo

Stars My Destination
After the third try, Elon Musk, the founder of SpaceX, co-founder of Paypal, chairman of SolarCity and chairman of Tesla Motors (beat that resumé!) was interviewed by WIRED about the difficulties of making his space rockets reach orbit:

Wired.com: How do you maintain your optimism?

Musk: Do I sound optimistic?

Wired.com: Yeah, you always do.

Musk: Optimism, pessimism, fuck that; we’re going to make it happen. As God is my bloody witness, I’m hell-bent on making it work.

Falcon 1: The First Privately Developed Rocket to Orbit the Earth
Well kids, perseverance pays off. On the 4th try, the 70-foot Falcon 1 rocket reached orbit wit a 364-pound dummy payload: “The data shows we achieved a super precise orbit insertion — middle of the bullseye — and then went on to coast and restart the second stage, which was icing on the cake.” Check out the video of the highlights of the launch.

“This really means a lot,” Musk told a crowd of whooping employees. “There’s only a handful of countries on Earth that have done this. It’s usually a country thing, not a company thing. We did it.”

Musk pledged to continue getting rockets into orbit, saying the company has resolved design issues that plagued previous attempts.

Last month, SpaceX lost three government satellites and human ashes including the remains of astronaut Gordon Cooper and “Star Trek” actor James Doohan after its third rocket was lost en route to space. The company blamed a timing error for the failure that caused the rocket’s first stage to bump into the second stage after separation.

SpaceX’s maiden launch in 2006 failed because of a fuel line leak. Last year, another rocket reached about 180 miles above Earth, but its second stage prematurely shut off.

The Falcon 1, at $7.9 million each, is what you could call the budget model. In fact, $7.9 million is basically pocket changed compared to what government agencies like NASA are used to paying to contractors like Lockheed Martin & co.

SpaceX is also working on the Falcon 9 (12,500 kg to low Earth orbit, and over 4,640 kg to geosynchronous transfer orbit) and Falcon 9 Heavy (28,000 kg to low Earth orbit, and over 12,000 kg to geosynchronous transfer orbit) to help NASA reach the International Space Station, among other things. These should cost between $36.75 million and $104 million each depending on the model and mission, and the first launch is scheduled for the first quarter of 2009.

Continue reading “SpaceX Falcon 1 Rocket Reaches Orbit on 4th Try” | >

Open source has emerged as a powerful set of principles for solving complex problems in fields as diverse as education and physical security. With roughly 60 million Americans suffering from a chronic health condition, traditional research progressing slowly, and personalized medicine on the horizon, the time is right to apply open source to health research. Advances in technology enabling cheap, massive data collection combined with the emerging phenomena of self quantification and crowdsourcing make this plan feasible today. We can all work together to cure disease, and here’s how.

Read more…

My proposal for the Society for Risk Analysis’s annual meeting in Boston has been accepted, in oral presentation format, for the afternoon of Wednesday, December 10th, 2008. Any Lifeboat members who will be in the area at the time are more than welcome to attend. Any suggestions for content would also be greatly appreciated; speaking time is limited to 15 minutes, with 5 minutes for questions. The abstract for the paper is as follows:

Global Risk: A Quantitative Analysis

The scope and possible impact of global, long-term risks presents a unique challenge to humankind. The analysis and mitigation of such risks is extremely important, as such risks have the potential to affect billions of people worldwide; however, little systematic analysis has been done to determine the best strategies for overall mitigation. Direct, case-by-case analysis can be combined with standard probability theory, particularly Laplace’s rule of succession, to calculate the probability of any given risk, the scope of the risk, and the effectiveness of potential mitigation efforts. This methodology can be applied both to well-known risks, such as global warming, nuclear war, and bio-terrorism, and lesser-known or unknown risks. Although well-known risks are shown to be a significant threat, analysis strongly suggests that avoiding the risks of technologies which have not yet been developed may pose an even greater challenge. Eventually, some type of further quantitative analysis will be necessary for effective apportionment of government resources, as traditional indicators of risk level- such as press coverage and human intuition- can be shown to be inaccurate, often by many orders of magnitude.

More details are available online at the Society for Risk Analysis’s website. James Blodgett will be presenting on the precautionary principle two days earlier (Monday, Dec. 8th).

Researchers have devised a rapid and efficient method for generating protein sentinels of the immune system, called monoclonal antibodies, which mark and neutralize foreign invaders.

For both ethical and practical reasons, monoclonals are usually made in mice. And that’s a problem, because the human immune system recognizes the mouse proteins as foreign and sometimes attacks them instead. The result can be an allergic reaction, and sometimes even death.

To get around that problem, researchers now “humanize” the antibodies, replacing some or all of mouse-derived pieces with human ones.

Wilson and Ahmed were interested in the immune response to vaccination. Conventional wisdom held that the B-cell response would be dominated by “memory” B cells. But as the study authors monitored individuals vaccinated against influenza, they found that a different population of B cells peaked about one week after vaccination, and then disappeared, before the memory cells kicked in. This population of cells, called antibody-secreting plasma cells (ASCs), is highly enriched for cells that target the vaccine, with vaccine-specific cells accounting for nearly 70 percent of all ASCs.

“That’s the trick,” said Wilson. “So instead of one cell in 1,000 binding to the vaccines, now it is seven in 10 cells.”

All of a sudden, the researchers had access to a highly enriched pool of antibody-secreting cells, something that is relatively easy to produce in mice, but hard to come by for human B cells.

To ramp up the production and cloning of these antibodies, the researchers added a second twist. Mouse monoclonal antibodies are traditionally produced in the lab from hybridomas, which are cell lines made by fusing the antibody-producing cell with a cancer cell. But human cells don’t respond well to this treatment. So Wilson and his colleagues isolated the ASC antibody genes and transferred them into an “immortalized” cell line. The result was the generation of more than 100 different monoclonals in less than a year, with each taking just a few weeks to produce.

In the event of an emerging flu pandemic, for instance, this approach could lead to faster production of human monoclonals to both diagnose and protect against the disease.

Journal Nature article: Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

Nature 453, 667–671 (29 May 2008) | doi:10.1038/nature06890; Received 16 October 2007; Accepted 4 March 2008; Published online 30 April 2008

Pre-existing neutralizing antibody provides the first line of defence against pathogens in general. For influenza virus, annual vaccinations are given to maintain protective levels of antibody against the currently circulating strains. Here we report that after booster vaccination there was a rapid and robust influenza-specific IgG+ antibody-secreting plasma cell (ASC) response that peaked at approximately day 7 and accounted for up to 6% of peripheral blood B cells. These ASCs could be distinguished from influenza-specific IgG+ memory B cells that peaked 14–21 days after vaccination and averaged 1% of all B cells. Importantly, as much as 80% of ASCs purified at the peak of the response were influenza specific. This ASC response was characterized by a highly restricted B-cell receptor (BCR) repertoire that in some donors was dominated by only a few B-cell clones. This pauci-clonal response, however, showed extensive intraclonal diversification from accumulated somatic mutations. We used the immunoglobulin variable regions isolated from sorted single ASCs to produce over 50 human monoclonal antibodies (mAbs) that bound to the three influenza vaccine strains with high affinity. This strategy demonstrates that we can generate multiple high-affinity mAbs from humans within a month after vaccination. The panel of influenza-virus-specific human mAbs allowed us to address the issue of original antigenic sin (OAS): the phenomenon where the induced antibody shows higher affinity to a previously encountered influenza virus strain compared with the virus strain present in the vaccine1. However, we found that most of the influenza-virus-specific mAbs showed the highest affinity for the current vaccine strain. Thus, OAS does not seem to be a common occurrence in normal, healthy adults receiving influenza vaccination.

Researchers from Imperial College in London, England, isolated the receptor in the lungs that triggers the immune overreaction to flu.

With the receptor identified, a therapy can be developed that will bind to the receptor, preventing the deadly immune response. Also, by targeting a receptor in humans rather than a particular strain of flu, therapies developed to exploit this discovery would work regardless of the rapid mutations that beguile flu vaccine producers every year.

The flu kills 250,000 to 500,000 people in an average year with epidemics reaching 1 to 2 million deaths (other than the spanish flu which was more severe

This discovery could lead to treatments which turn off the inflammation in the lungs caused by influenza and other infections, according to a study published today in the journal Nature Immunology. The virus is often cleared from the body by the time symptoms appear and yet symptoms can last for many days, because the immune system continues to fight the damaged lung. The immune system is essential for clearing the virus, but it can damage the body when it overreacts if it is not quickly contained.

The immune overreaction accounts for the high percentage of young, healthy people who died in the vicious 1918 flu pandemic. While the flu usually kills the very young or the sickly and old, the pandemic flu provoked healthy people’s stronger immune systems to react even more profoundly than usual, exacerbating the symptoms and ultimately causing between 50 and 100 million deaths world wide. These figures from the past make the new discovery that much more important, as new therapies based on this research could prevent a future H5N1 bird flu pandemic from turning into a repeat of the 1918 Spanish flu.

In the new study, the researchers gave mice infected with influenza a mimic of CD200, or an antibody to stimulate CD200R, to see if these would enable CD200R to bring the immune system under control and reduce inflammation.

The mice that received treatment had less weight loss than control mice and less inflammation in their airways and lung tissue. The influenza virus was still cleared from the lungs within seven days and so this strategy did not appear to affect the immune system’s ability to fight the virus itself.

The researchers hope that in the event of a flu pandemic, such as a pandemic of H5N1 avian flu that had mutated to be transmissible between humans, the new treatment would add to the current arsenal of anti-viral medications and vaccines. One key advantage of this type of therapy is that it would be effective even if the flu virus mutated, because it targets the body’s overreaction to the virus rather than the virus itself.

In addition to the possible applications for treating influenza, the researchers also hope their findings could lead to new treatments for other conditions where excessive immunity can be a problem, including other infectious diseases, autoimmune diseases and allergy.

Supercomputer

We are currently hosting lifeboat.com on free web space provided by rubyredlabs.com. Due to the growth in our traffic plus more general activity on this server, it would be best if we had our own server.

Note that we have additional space from KurzweilAI.net on a shared server (shared with many domains) but the shared server is always rather loaded since it has so many domains on it so we don’t host our main pages on it. (We use the shared server for backups, file transfers, and less important domains.)

Our current solution is to stay with the same provider as rubyredlabs.com but to move to our own machine. (This should simplify the transition.) The current provider is theplanet.com. We plan on getting: Intel Xeon 3210 Quad Core Kentsfield Processor, 250GB HDD, 4GB RAM, 2500GB bandwidth, 10 IPs, 100mbps uplink — $199 monthly / $25 setup.

We welcome any feedback. We are currently on a system equal to: Celeron 2.0, 80GB HDD, 1GB RAM, 750GB bandwidth, 5 IPs, 10mbps uplink — $89 monthly / $0 setup but don’t have access to all the systems resources. We just finished completing an upgrade so both our blog pages and regular web pages are cached, enabling us to handle a lot of traffic but it doesn’t help much if the server has activity on it besides ours which is not cached… We also upgraded our spam filter so it runs about one thousand times as fast which was rather helpful.

Our traffic is around 150GB but obviously if it surged a lot it is easier to pay for more bandwidth than to get a new machine on the spot. Also our current machine is running FreeBSD — we plan on getting Red Hat 5 since we have a choice.

We welcome your input on this!

UPDATE: Jaan Tallinn, cofounder of Skype, the only major IM client that both securely authenticates conversation. participants, and encrypts the communication, gets us started with a $300 donation. Our goal is to raise $2,500 to pay for a faster machine for a year.

UPDATE II: Chris Haley agrees to become System Administrator for our new machine. He also donates $1,500 bringing our Bigger Machine Fund to $1,925. Only $575 to go!

SUCCESS! We were able to quickly raise $3,400 for our Bigger Machine Fund — far exceeding our goal of $2,500. Additional funds raised will be used to pay for additional months, for improved network/software/hardware security, and for a backup plan. Long-term, we plan on hosting our site with more than one provider for the ultimate in backup plans. The more you donate, the more infrastructure we will implement.