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Category: life extension – Page 75
A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division. The findings, published in Cell, could one day lead to new interventions for a variety of conditions associated with aging, including neurodegenerative and cardiovascular diseases, diabetes, and cancer, as well as new therapies for a collection of diseases known as ribosomopathies.
“There is great interest in reducing senescence to slow or reverse aging or aging-associated diseases. We discovered a noncoding RNA that when inhibited strongly impairs senescence, suggesting that it could be a therapeutic target for conditions associated with aging,” said Joshua Mendell, M.D., Ph.D., Professor of Molecular Biology and a member of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. He is also a Howard Hughes Medical Institute Investigator.
Dr. Mendell led the study with co-first authors Yujing Cheng, Ph.D., a recent graduate of the Genetics, Development, and Disease graduate program; and Siwen Wang, M.D., a former postdoctoral researcher, both in the Mendell Lab.
Unfortunately, while the science behind sauna use for longevity seems more convincing than cold plunging, saunas themselves cost a lot more than cold plunges…
Heat therapy seems to be good for longevity, so we looked around for the top-rated home saunas to bring those health benefits to you.
Is it possible to live to 120? Yes, according to the burgeoning field of longevity science. Over twelve weeks, reporter Darren Mara puts his own body to the test to find out if aging really is a thing of the past.
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Pain management is an important component of caring for adults with cerebral palsy. However, it’s the least understood comorbidity in the adult cerebral palsy population.
A study led by Mark Peterson, Ph.D., M.S., FACSM, a professor of physical medicine and rehabilitation at University of Michigan Health, found that adults living with cerebral palsy had a very high occurrence of pain, with 90% having a pain history and 74% having multiple diagnoses of pain coming from different origins such as the lower back, irritable bowels, joint arthritis and chronic headaches.
The research is published in the journal JAMA Neurology.
(THE CONVERSATION) Racism steals time from people’s lives – possibly because of the space it occupies in the mind.
Question Is racial discrimination associated with brain connectivity, and are alterations in deep brain functional connectivity associated with accelerated epigenetic aging?
Findings In this cohort study of 90 Black women in the US, higher self-reported racial discrimination was associated with greater resting-state functional connectivity (RSFC) between the locus coeruleus (LC) and precuneus. Significant indirect effects were observed for the association between racial discrimination frequency and DNA methylation age acceleration.
Meaning These findings suggest that racial discrimination is associated with greater connectivity in pathways involved with rumination, which may increase vulnerability to stress-related disorders and neurodegenerative disease via epigenetic age acceleration.
Sorry, lol, i had to.
‘I’m never going to age’
It’s a crucial support to most everything our body does. When we’re young, our body is efficient at producing NAD.
As people age, production slowly tapers — which studies suggest might be one of the reasons we tend to feel worse as we get older.
But scientists caution that they have yet to design a NAD product that our body can use in the same way that it uses the NAD we produce naturally.
A group of scientists has devised a plan to safeguard Earth’s species in a cryogenic biorepository on the moon.
Intended to save species in the event of a disaster on Earth, the plan makes use of craters that are permanently in shadow and therefore cold enough to allow cryogenic preservation of biological material without using electricity or liquid nitrogen, according to research from a group led by scientists at the Smithsonian, published last week.
The paper, published in the journal BioScience, draws on the successful cryopreservation of skin samples from a fish, and outlines a method for creating a biorepository that would keep samples of other species safe.
An antibody treatment designed to revitalize an aging immune system delivers “surprising” results in elderly mice.