Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 65

Year 2021 😗😁😘

Researchers Prof. Judith Haendeler from the Medical Faculty and the molecular biologist Prof. Joachim Altschmied from the Department of Biology, together with their teams, have shown for the first time in the cardiovascular system that telomerase reverse transcriptase (TERT) within the mitochondria, the powerhouses of the cells, has a protective function in myocardial infarction. This work, which was performed together with other groups from the University Hospital Düsseldorf and the University Hospital Essen within the frame of the Collaborative Research Center 1,116, was recently published in the journal Circulation.

Cardiac muscle cells benefit from the increased mitochondrial function and are protected from cell death. Other also profit from increased mitochondrial function such as fibroblasts, which are essential for stable scarring after an infarction, and , which are needed for vascularization and thus blood supply in the infarct area.

In the , TERT is a component of the so-called “immortality enzyme” telomerase, for the discovery of which the Nobel Prize in Physiology or Medicine was awarded in 2009. Meanwhile, it has been shown by the two research groups at HHU, that TERT is also present in mitochondria in the cells of the cardiovascular system. However, until now it has not been possible to clearly distinguish between its functions in these two cell organelles.

Continue reading “‘Immortality protein’ within the mitochondria offers protection in myocardial infarction” | >

face_with_colon_three year 2023 The ultimate goal is to use crispr to modify genetic programming for eternal life this an example of heart age reversal.

An anti-aging gene found in centenarians has been shown to reverse the heart’s biological age by 10 years. This groundbreaking discovery, published in the journal Cardiovascular Research and led by scientists from the University of Bristol and MultiMedica Group in Italy, offers a potential target for heart failure patients.

Individuals who carry healthy mutant genes, commonly found in populations known for exceptional longevity such as the “blue zones,” often live to 100 years or more and remain in good health. These carriers are also less susceptible to cardiovascular complications. Scientists funded by the British Heart Foundation believe the gene helps keep their hearts youthful by guarding against diseases related to aging, such as heart failure.

In this new study, researchers demonstrate that one of these healthy mutant genes, previously proved particularly frequent in centenarians, can protect cells collected from patients with heart failure requiring cardiac transplantation.

Continue reading “Anti-Aging Gene Shown To Rewind Heart Age by 10 Years” | >

Gene therapy may be the best hope for curing retinitis pigmentosa (RP), an inherited condition that usually leads to severe vision loss and blinds 1.5 million people worldwide.

But there’s a huge obstacle: RP can be caused by mutations in over 80 different genes. To treat most RP patients with gene therapy, researchers would have to create a therapy for each gene—a nearly impractical task using current gene therapy strategies.

A more universal treatment may be forthcoming. Using CRISPR-based genome engineering, scientists at Columbia University Vagelos College of Physicians and Surgeons are designing a gene therapy with the potential to treat RP patients regardless of the underlying genetic defect.

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Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have now demonstrated that this is the case together with researchers from Germany, Austria and the USA. RNAs are generally short-lived molecules that are constantly reconstructed to adjust to environmental conditions. With their findings that have now been published in the journal Science, the research group hopes to decipher the complex aging process of the brain and gain a better understanding of related degenerative diseases.

Most cells in the human body are regularly renewed, thereby retaining their vitality. However, there are exceptions: the heart, the pancreas and the brain consist of cells that do not renew throughout the whole lifespan, and yet still have to remain in full working order. “Aging neurons are an important risk factor for neurodegenerative illnesses such as Alzheimer’s,” says Prof. Dr. Tomohisa Toda, Professor of Neural Epigenomics at FAU and at the Max Planck Center for Physics and Medicine in Erlangen. “A basic understanding of the aging process and which key components are involved in maintaining cell function is crucial for effective treatment concepts:”

In a joint study conducted together with neuroscientists from Dresden, La Jolla (USA) and Klosterneuburg (Austria), the working group led by Toda has now identified a key component of brain aging: the researchers were able to demonstrate for the first time that certain types of ribonucleic acid (RNA) that protect genetic material exist just as long as the neurons themselves. “This is surprising, as unlike DNA, which as a rule never changes, most RNA molecules are extremely short-lived and are constantly being exchanged,” Toda explains.

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Recent research published in Nature Communications from the Nuffield Department of Clinical Neurosciences at the University of Oxford has identified 15 modifiable risk factors for dementia, and of those diabetes, alcohol intake, and traffic-related air pollution are the most harmful.

Previous research from this group revealed an area of weakness in the brain of a specific network of higher-order regions that only develop later in adolescence but also display earlier degeneration in old age, and they showed that this brain network is particularly vulnerable to Alzheimer’s disease and schizophrenia. This study investigated genetic and modifiable influences on these regions by utilizing data from the UK Biobank.

This study examined 161 risk factors for dementia by analyzing brain scans of 40,000 people over the age of 45 years old. The modifiable risk factors were ranked by their impact on the vulnerable brain network over and above the natural effects of aging, classifying them into 15 broad categories: blood pressure, diabetes, weight, cholesterol, smoking, inflammation, hearing, sleep, diet, physical activity, education, socialism, pollution, alcohol consumption, and depressive mood.

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